SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_080764
Gene Symbol: ZNF280B
Description: Homo sapiens zinc finger protein 280B (ZNF280B), mRNA.
Gene Location: chr22(-):22838771-22863505
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr22:g.22484753T>C COSN1895385 RK029_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-138-5p ggaaagcgACCAGCatcaa
 0 AGCUGGUG m6b Created no TS -0.131000 No effect
hsa-miR-3663-5p ggaaagcGACCAGCatcaa
 0 GCUGGUCU m7a Created NA NA -0.380000
hsa-miR-4728-3p ggaaagcgaTCAGCATcaa
 0 CAUGCUGA m7b (m7b->m6b) -0.264000 -0.119000 0.370000
hsa-miR-4790-5p ggAAAGCGATcagcatcaa
 1
 AUCGCUUU m8a (m8a->m7b) -0.198000 -0.171000 0.340000
hsa-miR-138-5p ggaaagcgACCAGCatcaa
 0 AGCUGGUG m6b Created no TS -0.131000 No effect
hsa-miR-3663-5p ggaaagcGACCAGCatcaa
 0 GCUGGUCU m7a Created NA NA -0.380000
hsa-miR-4728-3p ggaaagcgaTCAGCATcaa
 0 CAUGCUGA m7b (m7b->m6b) -0.264000 -0.119000 0.370000
hsa-miR-4790-5p ggAAAGCGATcagcatcaa
 1
 AUCGCUUU m8a (m8a->m7b) -0.198000 -0.171000 0.340000
hsa-miR-138-5p ggaaagcgACCAGCatcaa
 0 AGCUGGUG m6b Created no TS -0.131 No effect
hsa-miR-3663-5p ggaaagcGACCAGCatcaa
 0 GCUGGUCU m7a Created NA NA -0.38
hsa-miR-4728-3p ggaaagcgaTCAGCATcaa
 0 CAUGCUGA m7b (m7b->m6b) -0.264 -0.119 0.37
hsa-miR-4790-5p ggAAAGCGATcagcatcaa
 0 AUCGCUUU m8a (m8a->m7b) -0.198 -0.171 0.34

Mutation Mutation ID Sample Name Cancer Type
chr22:g.22484970G>A COSN10028387 C0020T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3135a ttccCCTAGGCctgcatgg
 8
 UGCCUAGG m7b Disrupted -0.135000 no TS 5.780000
hsa-miR-3665 ttcccctagACCTGCatgg
 0 AGCAGGUG m6b Created no TS -0.108000 -0.720000
hsa-miR-4650-5p ttcccctAGGCCTGcatgg
 9
 UCAGGCCU m7b Disrupted -0.124000 no TS 0.030000
hsa-miR-601 ttcccCTAGACCtgcatgg
 0 UGGUCUAG m7b Created no TS -0.100000 -2.600000
hsa-miR-657 ttcccctagACCTGCatgg
 0 GGCAGGUU m6b Created no TS -0.115000 -0.260000

Mutation Mutation ID Sample Name Cancer Type
chr22:g.22485013C>A COSN195221 PD4116a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1264 atccaAAGACTTtgcacat
 6
 CAAGUCUU m7b Disrupted 0.022000 0.068000 No effect
hsa-miR-518a-5p atccaaagaCTTTGCAcat
 8
 CUGCAAAG m7b (m7b->m6b) -0.061000 no TS -2.200000
hsa-miR-527 atccaaagaCTTTGCAcat
 8
 CUGCAAAG m7b (m7b->m6b) -0.061000 no TS -2.200000
hsa-miR-1264 atccaAAGACTTtgcacat
 0 CAAGUCUU m7b Disrupted 0.022 0.068 No effect
hsa-miR-518a-5p atccaaagaCTTTGCAcat
 0 CUGCAAAG m7b (m7b->m6b) -0.061 no TS -2.2
hsa-miR-527 atccaaagaCTTTGCAcat
 0 CUGCAAAG m7b (m7b->m6b) -0.061 no TS -2.2

Mutation Mutation ID Sample Name Cancer Type
chr22:g.22485192G>C COSN10028388 C0062T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4636 tgctcttaACGAGTacata
 0 AACUCGUG m6b Created no TS -0.172000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr22:g.22485480G>T COSN8014476 8068976 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3133 ctatactaGTTCTTTtcag
 7
 UAAAGAAC m7b Created 0.094000 0.125000 -1.010000
hsa-miR-3923 ctaTACTAGTTcttttcag
 0 AACUAGUA m8a Created no TS -0.095000 -4.360000
hsa-miR-4511 ctatactAGTTCTTttcag
 0 GAAGAACU m7b Created -0.112000 -0.136000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr22:g.22486085T>A COSN5989317 RK181_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5003-3p tgcaaGAAAAGTctctcta
 0 UACUUUUC m7b Created no TS 0.104000 -0.980000

Mutation Mutation ID Sample Name Cancer Type
chr22:g.22486496G>T COSN1895386 RK024_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-320a gccaCAGCTTTaaagcaag
 2
 AAAAGCUG m7b Created -0.149000 -0.169000 -3.380000
hsa-miR-320b gccaCAGCTTTaaagcaag
 2
 AAAAGCUG m7b Created -0.149000 -0.169000 -3.380000
hsa-miR-320c gccaCAGCTTTaaagcaag
 2
 AAAAGCUG m7b Created -0.149000 -0.169000 -0.940000
hsa-miR-320d gccaCAGCTTTaaagcaag
 2
 AAAAGCUG m7b Created -0.149000 -0.169000 -1.650000
hsa-miR-320e gccaCAGCTTTaaagcaag
 0 AAAGCUGG m7a Created NA NA -0.140000
hsa-miR-4429 gccaCAGCTTTaaagcaag
 2
 AAAAGCUG m7b Created -0.149000 -0.200000 -8.420000
hsa-miR-9-3p gccacAGCTTTAaagcaag
 0 AUAAAGCU m7b Created no TS 0.120000 0.370000
hsa-miR-320a gccaCAGCTTTaaagcaag
 2
 AAAAGCUG m7b Created -0.149000 -0.169000 -3.380000
hsa-miR-320b gccaCAGCTTTaaagcaag
 2
 AAAAGCUG m7b Created -0.149000 -0.169000 -3.380000
hsa-miR-320c gccaCAGCTTTaaagcaag
 2
 AAAAGCUG m7b Created -0.149000 -0.169000 -0.940000
hsa-miR-320d gccaCAGCTTTaaagcaag
 2
 AAAAGCUG m7b Created -0.149000 -0.169000 -1.650000
hsa-miR-320e gccaCAGCTTTaaagcaag
 0 AAAGCUGG m7a Created NA NA -0.140000
hsa-miR-4429 gccaCAGCTTTaaagcaag
 2
 AAAAGCUG m7b Created -0.149000 -0.200000 -8.420000
hsa-miR-9-3p gccacAGCTTTAaagcaag
 0 AUAAAGCU m7b Created no TS 0.120000 0.370000
hsa-miR-320a gccaCAGCTTTaaagcaag
 0 AAAAGCUG m7b Created -0.149 -0.169 -3.38
hsa-miR-320b gccaCAGCTTTaaagcaag
 0 AAAAGCUG m7b Created -0.149 -0.169 -3.38
hsa-miR-320c gccaCAGCTTTaaagcaag
 0 AAAAGCUG m7b Created -0.149 -0.169 -0.94
hsa-miR-320d gccaCAGCTTTaaagcaag
 0 AAAAGCUG m7b Created -0.149 -0.169 -1.65
hsa-miR-320e gccaCAGCTTTaaagcaag
 0 AAAGCUGG m7a Created NA NA -0.14
hsa-miR-4429 gccaCAGCTTTaaagcaag
 0 AAAAGCUG m7b Created -0.149 -0.2 -8.42
hsa-miR-9-3p gccacAGCTTTAaagcaag
 0 AUAAAGCU m7b Created no TS 0.12 0.37

Mutation Mutation ID Sample Name Cancer Type
chr22:g.22487282A>T COSN8014477 8015259 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3163 tttATTTTATttttttgta
 9
 UAUAAAAU m7b (m6c->m7b) -0.058000 -0.048000 -0.200000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
22484750 rs414781 T G hsa-miR-4728-3p
hsa-miR-8075
0 cgaTCAGCATcaa
cgATCAGCAtcaa
 Created
Created
N
N
 -0.145
-0.092
T hsa-miR-1272
hsa-miR-3682-3p
0 cgaTCATCATcaa
cgATCATCAtcaa
 Disrupted
Disrupted
N
N
 -0.094
-0.122
22487462 rs6002491 A
T hsa-miR-3163
2
 ATTTTATtttttt
 Created
N
 -0.071

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