SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_006887
Gene Symbol:	ZFP36L2
Description:	Homo sapiens zinc finger protein 36, C3H type-like 2 (ZFP36L2), mRNA.
Gene Location:	chr2(-):43449540-43453745
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.43222548G>A			COSN7129830		8057559		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-138-1-3p	ctttggacaGAAGTAGgtt	12	GCUACUUC	m7b	(m7b->m6b)	-0.269000	-0.079000	0.120000
hsa-miR-2355-3p	ctttGGACAAaagtaggtt	0	AUUGUCCU	m6b	Created	no TS	-0.144000	-10.680000
hsa-miR-3182	ctttggACAGAAGtaggtt	14	GCUUCUGU	m7b	Disrupted	-0.185000	no TS	1.030000
hsa-miR-3682-5p	ctttggacAGAAGTAGgtt	14	CUACUUCU	m8a	Disrupted	-0.103000	no TS	No effect
hsa-miR-4646-3p	ctttGGACAAaagtaggtt	0	AUUGUCCC	m6b	Created	no TS	-0.148000	-6.600000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.43223173GAT>-			ICGC_sm302247		RK068_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.43223226T>C			COSN9374524		AOCS-112-1-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3121-3p	atgtaataTCTATTTcatt	19	UAAAUAGA	m7b	Created	0.048000	-0.006000	No effect
hsa-miR-3145-3p	atgtAATATCTatttcatt	0	AGAUAUUU	m7a	Created	NA	NA	-0.030000
hsa-miR-3121-3p	atgtaataTCTATTTcatt	19	UAAAUAGA	m7b	Created	0.048000	-0.006000	No effect
hsa-miR-3145-3p	atgtAATATCTatttcatt	0	AGAUAUUU	m7a	Created	NA	NA	-0.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.43223457A>G			COSN1840905		RK083_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.43223737T>A			COSN5504254		RK125_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-27a-5p	cttgatagTAAGCCCTcag	0	AGGGCUUA	m8a	Created	no TS	-0.126000	-0.010000
hsa-miR-3158-3p	cttgatagtAAGCCCTcag	0	AAGGGCUU	m7b	(m6b->m7b)	no TS	-0.168000	No effect
hsa-miR-644b-5p	cttgatagTTAGCCCtcag	2	UGGGCUAA	m7b	Disrupted	-0.326000	-0.171000	0.600000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.43224044A>C			COSN4804522		tumor_4177376		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-375	gttGAACAAAatattcaca	0	UUUGUUCG	m7a	(m7a->m6b)	-0.186000	-0.104000	0.080000
hsa-miR-4781-3p	gttgaaCAACATattcaca	0	AAUGUUGG	m6b	Created	no TS	-0.057000	-0.050000
hsa-miR-5583-3p	gttgaacaaCATATTCaca	0	GAAUAUGG	m7a	(m6a->m7a)	NA	NA	3.050000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.43224105A>T			COSN8609230		363_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-548c-3p	tttttttttATTTTTatta	1	CAAAAAUC	m6b	Disrupted	0.231000	0.162000	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
43224008	rs73923539	C	C	hsa-miR-129-5p hsa-miR-375 hsa-miR-4273 hsa-miR-4677-5p hsa-miR-6739-3p hsa-miR-7156-5p	0	atagaaCAAAAAA ataGAACAAAaaa atAGAACAAaaaa atAGAACAAaaaa atAGAACAAAaaa atAGAACAAaaaa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N HT N N N N	0.018 -0.104 -0.101 -0.094 -0.285 -0.091
			A	hsa-miR-4482-3p hsa-miR-7159-3p	9 9	ATAGAAAaaaaaa ATAGAAAaaaaaa	Created Created	N N	-0.074 -0.029
43224046	rs199657841	-	CA	hsa-miR-375 hsa-miR-6739-3p	2 2	gttGAACAAAatatt gttGAACAAAatatt	Unknown Unknown	HT N	-0.081 -0.063
			-	hsa-miR-1305 hsa-miR-335-3p	1 2	GTTGAAAAatatt gtTGAAAAAtatt	Unknown Unknown	N N	-0.173 0.024
43224105	rs3209872	A	A	hsa-miR-548c-3p	1	ttttttATTTTTA	Disrupted	N	0.069
43224111	rs191576047	T
			A	hsa-miR-548c-3p	4	ctttttATTTTTA	Created	N	0.059

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