SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_133646 |
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Gene Symbol: | ZAK |
Description: | Homo sapiens sterile alpha motif and leucine zipper containing kinase AZK (ZAK), transcript variant 1, mRNA. |
Gene Location: | chr2(+):173940564-174091873 |
Browse Associations | |
Browse Pathways |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.173221793C>G | COSN15179213 | SM-4AX86 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-568 |
tcctaTATACAatatagga |
0 | AUGUAUAA | m6b | Disrupted | -0.012000 | 0.044000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.173221799A>C | ZAK_E12_UTR_3 | SJHYPO052_R | Hypodiploid_ALL | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-337-3p |
atacaaTATAGGActttta |
2 |
CUCCUAUA | m7b | Disrupted | -0.191 | no TS | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.173221897C>T | COSN7117119 | 8057543 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4495 |
ttttaaaaaTTTACATTtt |
3 |
AAUGUAAA | m8a | (m7b->m8a) | 0.015000 | -0.132000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.173222031C>T | COSN15436115 | AOCS-150-8-X | [ovary][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-624-3p |
gtaagACCTTGTctctact |
0 | CACAAGGU | m7b | Created | no TS | -0.116000 |
-0.010000 |
|
hsa-miR-624-3p |
gtaagACCTTGTctctact |
0 | CACAAGGU | m7b | Created | no TS | -0.116000 |
-0.010000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.173223110G>C | COSN7117120 | 8015858 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-146a-3p |
atgccccTTCAGAGGtgaa |
4 |
CCUCUGAA | m8a | Created | -0.146000 | -0.040000 | No effect | |
hsa-miR-3179 |
atgCCCCTTCagaggtgaa |
0 | AGAAGGGG | m7b | (m6b->m7b) | no TS | -0.056000 |
-6.040000 |
|
hsa-miR-513c-5p |
atgcccCTTGAGAggtgaa |
2 |
UUCUCAAG | m7b | Disrupted | 0.126000 | -0.007000 |
0.850000 |
|
hsa-miR-514b-5p |
atgcccCTTGAGAggtgaa |
2 |
UUCUCAAG | m7b | Disrupted | 0.116000 | 0.011000 |
0.030000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.173223115G>T | COSN9116737 | AOCS-092-3-3 | [ovary][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1305 |
ccttgagaGTTGAAAAata |
3 |
UUUUCAAC | m8a | Created | 0.468000 | 0.629000 |
-4.140000 |
|
hsa-miR-1306-5p |
ccttgaGAGGTGaaaaata |
5 |
CCACCUCC | m6b | Disrupted | 0.015000 | 0.021000 | No effect | |
hsa-miR-5096 |
ccttgagaGGTGAAAaata |
2 |
GUUUCACC | m7b | Disrupted | 0.161000 | 0.096000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.173223135A>T | COSN9116738 | AOCS-134-3-9 | [ovary][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4724-5p |
cacataatGTTCAGTatgc |
6 |
AACUGAAC | m7b | Created | 0.067000 | 0.068000 |
-2.030000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.173223368T>C | COSN8273852 | ASHPC_0029_Pa_P | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1245a |
aaagGATCACTgtgcggat |
0 | AAGUGAUC | m7b | Created | no TS | 0.034000 |
-0.220000 |
|
hsa-miR-128 |
aaaggatCACTGTGcggat |
0 | UCACAGUG | m7b | Created | no TS | 0.002000 |
-1.570000 |
|
hsa-miR-3681-3p |
aaaggatCACTGTGcggat |
0 | ACACAGUG | m7b | Created | no TS | -0.017000 |
-0.010000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.173223717A>G | COSN1807018 | RK126_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1273d |
aaaagATGGGTTCccccac |
0 | GAACCCAU | m8a | Created | no TS | 0.053000 | No effect | |
hsa-miR-1273d |
aaaagATGGGTTCccccac |
0 | GAACCCAU | m8a | Created | no TS | 0.053 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.173225519G>A | ICGC_70577EC4-2A78-11E2-96E7-04FD496BB9B8 | CPCG_0102_Pr_P_P1 | ProstateCancer(OICR,CA) | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1247-3p |
cttgaaCCCGGGaggcaga |
1 |
CCCCGGGA | m6b | Disrupted | -0.066 | no TS |
5.76 |
|
hsa-miR-1343 |
cttgaaCCCAGGAGgcaga |
0 | CUCCUGGG | m8a | Created | 0.005 | 0.008 |
-0.64 |
|
hsa-miR-4532 |
cttgaaCCCGGGaggcaga |
1 |
CCCCGGGG | m6b | Disrupted | -0.058 | no TS |
9.72 |
|
hsa-miR-660-3p |
cttgaaccCAGGAGGcaga |
0 | ACCUCCUG | m7b | Created | -0.146 | -0.087 |
-0.04 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr2:g.173226858T>C | COSN8607997 | J65_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-142-5p |
atcACTTTATtgttttttt |
0 | CAUAAAGU | m7b | (m7b->m6b) | 0.185000 | 0.253000 | No effect |
hsa-miR-545-5p |
atcacTTTACTGttttttt |
6 |
UCAGUAAA | m7b | Created | 0.014000 | -0.111000 | No effect |
hsa-miR-5590-3p |
atcACTTTATTgttttttt |
0 | AAUAAAGU | m8a | Disrupted | 0.222000 | 0.300000 | No effect |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
173222498 | rs77431903 | - | C |
hsa-miR-3149 hsa-miR-568 hsa-miR-6844 |
6 4 5 |
tttATACAAAgag tTTATACAAagag tttatACAAAGAg |
Unknown Unknown Unknown |
N N N |
0.093 0.032 -0.027 |
T |
hsa-miR-190a-3p hsa-miR-410-3p hsa-miR-6083 |
4 5 6 |
ttTATATAAagag tTTATATAaagag tttATATAAAgag |
Unknown Unknown Unknown |
N N N |
0.143 0.133 0.133 |
|||
173222499 | rs138772418 | - | A |
hsa-miR-130b-5p hsa-miR-3149 hsa-miR-4753-3p hsa-miR-568 hsa-miR-6844 |
6 6 6 4 5 |
ttatacAAAGAGA ttATACAAAgaga ttatacAAAGAGA TTATACAAagaga ttatACAAAGAga |
Unknown Unknown Unknown Unknown Unknown |
N N N N N |
No Change 0.093 -0.017 0.032 -0.027 |
G |
hsa-miR-1236-3p hsa-miR-6515-3p |
6 6 |
ttatacGAAGAGA ttatacGAAGAGA |
Unknown Unknown |
N N |
-0.002 -0.006 |
|||
173224648 | rs139080666 | T | C |
hsa-miR-151a-5p hsa-miR-151b hsa-miR-3150b-3p hsa-miR-4784 |
0 |
tCTCCTCGtagaa tCTCCTCGtagaa TCTCCTCgtagaa TCTCCTCgtagaa |
Created Created Created Created |
N N N N |
-0.164 -0.164 -0.025 -0.007 |
T |
hsa-miR-1283 hsa-miR-4428 hsa-miR-624-3p |
1 1 0 |
tctccTTGTAGAa TCTCCTTgtagaa tctCCTTGTAgaa |
Disrupted Disrupted Disrupted |
N N N |
0.095 0.003 0.032 |