SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_022459
Gene Symbol: XPO4
Description: Homo sapiens exportin 4 (XPO4), mRNA.
Gene Location: chr13(-):21351467-21476913
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr13:g.20778369T>C COSN8776346 AOCS-116-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3662 gtTCATTTTCaacctgaat
 2
 GAAAAUGA m8a (m7b->m8a) 0.391000 0.418000 No effect
hsa-miR-548c-3p gttcATTTTTaacctgaat
 4
 CAAAAAUC m6b Disrupted 2.286000 2.127000 0.080000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.20778393A>G COSN5189800 SS6003117 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4325 ttaaagaAAGTGCAtcttt
 12
 UUGCACUU m7b Created -0.217000 -0.339000 -0.280000
hsa-miR-586 ttaaagaaAATGCATcttt
 2
 UAUGCAUU m7b Disrupted -0.081000 0.032000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr13:g.20778949T>C COSN6223339 RK214_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-374a-3p tcaggtTGATAAaatttta
 0 CUUAUCAG m6b Disrupted 0.074000 no TS No effect
hsa-miR-505-3p tcagGTTGACaaaatttta
 0 CGUCAACA m6b Created no TS -0.024000 -0.120000
hsa-miR-590-3p tcaggttgaTAAAATTtta
 3
 UAAUUUUA m7b (m7b->m6b) 1.546000 1.381000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr13:g.20780321G>T COSN6538637 ICGC_MB69 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3653 catcaTTCTTAaccctgaa
 2
 CUAAGAAG m6b Created 0.023000 0.157000 -0.010000
hsa-miR-3658 catcaTTCTTAAccctgaa
 2
 UUUAAGAA m7b Created 0.179000 0.330000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.20780980T>C COSN6223340 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4475 attttattTCCCTTGaccc
 0 CAAGGGAC m7a Created NA NA -0.040000
hsa-miR-5584-5p attttaTTTCCCTtgaccc
 0 CAGGGAAA m7b Created no TS -0.031000 -0.750000
hsa-miR-561-5p attttatttTCCTTGAccc
 2
 AUCAAGGA m7b (m7b->m6b) -0.050000 no TS 0.960000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.20781345T>C COSN8776347 AOCS-139-12-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4691-3p tcaggGTGGCTGtgtccat
 0 CCAGCCAC m7b Created -0.017000 -0.026000 -0.890000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.20781891T>C COSN7395154 8031146 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3148 tttttTTTTTCCccttaaa
 1
 UGGAAAAA m7b Disrupted 0.158000 0.177000 No effect
hsa-miR-4668-5p ttttttTTTTCCCcttaaa
 3
 AGGGAAAA m7b Disrupted 0.076000 0.115000 0.010000
hsa-miR-4716-3p ttttttttTCCCCCTTaaa
 0 AAGGGGGA m8a Created no TS -0.242000 -0.020000
hsa-miR-625-5p tttttttTTCCCCCTtaaa
 5
 AGGGGGAA m8a Created -0.121000 -0.262000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.20782736A>G COSN6223341 RK200_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-103b ttagctGCTATGAacctgt
 11
 UCAUAGCC m7a Disrupted -0.280000 -0.246000 0.260000
hsa-miR-3120-3p ttagcTGCTGTGaacctgt
 2
 CACAGCAA m7a Created 0.037000 0.037000 No effect
hsa-miR-376a-3p ttagctgCTATGAacctgt
 4
 AUCAUAGA m6b Disrupted 0.090000 0.060000 No effect
hsa-miR-376b ttagctgCTATGAacctgt
 4
 AUCAUAGA m6b Disrupted 0.090000 0.060000 No effect
hsa-miR-4524a-5p ttaGCTGCTATgaacctgt
 1
 AUAGCAGC m8a Disrupted -0.274000 -0.128000 0.330000
hsa-miR-4524b-5p ttaGCTGCTATgaacctgt
 1
 AUAGCAGC m8a Disrupted -0.274000 -0.128000 0.040000

Mutation Mutation ID Sample Name Cancer Type
chr13:g.20782874T>C 9_77158 CRC-7-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
20780094 rs190606708 A A hsa-miR-103b
hsa-miR-4662a-5p
2
2
 ttGGCTATGAggt
TTGGCTAtgaggt
 Disrupted
Disrupted
N
N
 -0.132
-0.038
C hsa-miR-6501-3p
2
 ttgGCTCTGAggt
 Created
N
 -0.011
20781891 rs147997558 - T hsa-miR-3148
hsa-miR-4668-5p
hsa-miR-6783-5p
1
1
1
 ttTTTTTCCcctt
tttTTTTCCCctt
tttttTTCCCCTt
 Unknown
Unknown
Unknown
N
N
N
 -0.004
-0.013
0.008
-

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