SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_003761
Gene Symbol:	VAMP8
Description:	Homo sapiens vesicle-associated membrane protein 8 (endobrevin) (VAMP8), mRNA.
Gene Location:	chr2(+):85804613-85809156
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.85581748C>T			COSN166155		GC8_T		[stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4709-3p	tgcccttCTCTTCAgggac	6	UUGAAGAG	m7b	Disrupted	-0.105000	no TS	0.290000
hsa-miR-4709-3p	tgcccttCTCTTCAgggac	6	UUGAAGAG	m7b	Disrupted	-0.105000	no TS	0.290000
hsa-miR-4709-3p	tgcccttCTCTTCAgggac	6	UUGAAGAG	m7b	Disrupted	-0.105000	no TS	0.290000
hsa-miR-4709-3p	tgcccttCTCTTCAgggac	6	UUGAAGAG	m7b	Disrupted	-0.105	no TS	0.29

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.85581859T>C			COSN8868361		SNUH_G26_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3529-3p	ctgctgccaTGTTGTatgc	2	AACAACAA	m6b	Disrupted	0.004000	no TS	-0.500000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
85581748	rs1058588	C	C	hsa-miR-4709-3p hsa-miR-6770-5p	6 3	ccttCTCTTCAgg CCTTCTCttcagg	Disrupted Disrupted	N N	-0.105 -0.115
85581859	rs1010	C	T	hsa-miR-3529-3p hsa-miR-942-3p	2 1	ctgccaTGTTGTA ctGCCATGTtgta	Created Created	N N	0.004 -0.17

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