SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_130466
Gene Symbol:	UBE3B
Description:	Homo sapiens ubiquitin protein ligase E3B (UBE3B), transcript variant 1, mRNA.
Gene Location:	chr12(+):109915438-109974507
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.109535311A>T			COSN15356577		AOCS-034-3-8		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1231	tcttcCCAGACAgccaggc	3	GUGUCUGG	m7b	Disrupted	-0.042000	no TS	0.220000
hsa-miR-3120-5p	tcttccCAGACAGccaggc	2	CCUGUCUG	m7b	Disrupted	-0.010000	no TS	No effect
hsa-miR-4314	tctTCCCAGAcagccaggc	2	CUCUGGGA	m7b	(m7b->m6b)	-0.166000	-0.094000	0.010000
hsa-miR-4646-5p	tcTTCCCAGTcagccaggc	2	ACUGGGAA	m8a	(m7a->m8a)	-0.239000	-0.145000	0.390000
hsa-miR-626	tcttcccAGACAGCcaggc	2	AGCUGUCU	m7b	Disrupted	-0.165000	-0.144000	No effect
hsa-miR-1231	tcttcCCAGACAgccaggc	3	GUGUCUGG	m7b	Disrupted	-0.042000	no TS	0.220000
hsa-miR-3120-5p	tcttccCAGACAGccaggc	2	CCUGUCUG	m7b	Disrupted	-0.010000	no TS	No effect
hsa-miR-4314	tctTCCCAGAcagccaggc	2	CUCUGGGA	m7b	(m7b->m6b)	-0.166000	-0.094000	0.010000
hsa-miR-4646-5p	tcTTCCCAGTcagccaggc	2	ACUGGGAA	m8a	(m7a->m8a)	-0.239000	-0.145000	0.390000
hsa-miR-626	tcttcccAGACAGCcaggc	2	AGCUGUCU	m7b	Disrupted	-0.165000	-0.144000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.109535343C>A			COSN10097412		C0089T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1539	agggaaGCGCAGGcgcctg	2	UCCUGCGC	m7b	Disrupted	-0.207000	no TS	8.330000
hsa-miR-191-3p	agggaAGCGCAGgcgcctg	1	GCUGCGCU	m7b	Disrupted	-0.115000	no TS	No effect
hsa-miR-4790-5p	agggAAGCGAaggcgcctg	0	AUCGCUUU	m6b	Created	no TS	-0.071000	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.109535416C>T			COSN5930002		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3622b-5p	cgcgctCCATGCCgcggcc	2	AGGCAUGG	m7b	Created	-0.277000	-0.316000	No effect
hsa-miR-4304	cgcgctcCATGCCGcggcc	2	CCGGCAUG	m7b	Created	-0.190000	-0.295000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.109536322G>A			COSN8694264		AOCS-138-3-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4643	cttctgaaCATGTGTgcgc	0	GACACAUG	m7b	Created	no TS	-0.079000	-0.690000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
109535341	rs191308411	C	C	hsa-miR-1539 hsa-miR-191-3p	2 1	gggaaGCGCAGGc gggaAGCGCAGgc	Disrupted Disrupted	N N	-0.207 -0.115
			T	hsa-miR-4325 hsa-miR-4793-3p	1 1	gggAAGTGCAggc gggaAGTGCAGgc	Created Created	N N	0.037 -0.037
109535910	rs189714060	G	G	hsa-miR-5001-3p	6	actgAGGCAGAgg	Disrupted	N	-0.028
			A	hsa-miR-3120-5p hsa-miR-4264 hsa-miR-4797-3p hsa-miR-6888-3p	6 3 3 6	actgAGACAGAgg ACTGAGAcagagg ACTGAGAcagagg actgAGACAGAgg	Created Created Created Created	N N N N	-0.004 0.002 -0.004 0.012

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