SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000462
Gene Symbol: UBE3A
Description: Homo sapiens ubiquitin protein ligase E3A (UBE3A), transcript variant 2, mRNA.
Gene Location: chr15(-):25582395-25684175
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr15:g.25337522C>A COSN7039633 8034061 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-2-3p gttaTGTACAataatgcta
 0 CUGUACAG m6b Created no TS -0.098000 -0.020000
hsa-let-7g-3p gttaTGTACAataatgcta
 0 CUGUACAG m6b Created no TS -0.095000 -0.010000
hsa-miR-1263 gttatGTACCATaatgcta
 0 AUGGUACC m7a Disrupted NA NA 5.470000
hsa-miR-150-3p gttaTGTACCAtaatgcta
 10
 CUGGUACA m7b Disrupted -0.253000 no TS No effect
hsa-miR-493-5p gttATGTACAAtaatgcta
 19
 UUGUACAU m8a Created -0.119000 -0.395000 -2.630000
hsa-miR-5579-5p gttatGTACCATAatgcta
 10
 UAUGGUAC m8a Disrupted -0.411000 no TS 4.940000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.25337753T>A COSN6268465 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3074-3p acatTGATATatccttttg
 10
 GAUAUCAG m6b Disrupted -0.015000 no TS 9.610000
hsa-miR-374a-3p acatTGATAAatccttttg
 0 CUUAUCAG m6b Created no TS 0.000000 -0.010000
hsa-miR-541-5p acattgataAATCCTTTtg
 11
 AAAGGAUU m8a (m7a->m8a) -0.213000 -0.383000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.25338451C>A COSN14985959 SM-4AX85 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-129-5p acagcaCAAAAAattaaaa
 0 CUUUUUGC m6b Created -0.026000 0.054000 -2.530000
hsa-miR-2113 acaGCACAAAaaattaaaa
 0 AUUUGUGC m7b (m6c->m7b) no TS -0.211000 -0.130000
hsa-miR-4775 acagcacaaAAAATTAAaa
 2
 UUAAUUUU m8a (m7a->m8a) 0.158000 0.147000 -2.840000
hsa-miR-5010-3p acagCACAAAAaattaaaa
 0 UUUUGUGU m7a Created no TS -0.014000 -4.480000
hsa-miR-590-3p acagcacaaAAAATTAaaa
 0 UAAUUUUA m7a (m6a->m7a) no TS 0.133000 -2.180000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.25338508G>T COSN8171457 PCSI_0305_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3667-3p agatggaAGGAAGGgagaa
 0 ACCUUCCU m7b Disrupted -0.755000 -0.509000 3.560000
hsa-miR-3682-5p agatgGAAGTAagggagaa
 5
 CUACUUCU m6b Created -0.102000 -0.137000 -2.360000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.25338688C>T COSN15243785 LP6007420-DNA_A01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-302a-5p cgtaaccTTTAAGTatgtg
 0 ACUUAAAC m7a Created NA NA -1.890000
hsa-miR-4635 cgtaacCTTCAAGtatgtg
 15
 UCUUGAAG m7b Disrupted -0.091000 no TS 0.050000
hsa-miR-493-3p cgtaACCTTCAagtatgtg
 15
 UGAAGGUC m7a Disrupted -0.260000 -0.153000 0.020000
hsa-miR-548m cgtaACCTTTaagtatgtg
 0 CAAAGGUA m6b Created no TS -0.057000 -6.230000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.25339119T>C ICGC_AD607A3C-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-19a-5p aaaacaaaaCAAAACaaaa
 0 AGUUUUGC m6b Created -0.06 -0.1 -0.06
hsa-miR-19b-1-5p aaaacaaaaCAAAACaaaa
 0 AGUUUUGC m6b Created -0.06 -0.1 -0.68
hsa-miR-19b-2-5p aaaacaaaaCAAAACaaaa
 0 AGUUUUGC m6b Created -0.06 -0.1 -1.65
hsa-miR-2052 aaaacaaaaCAAAACAaaa
 0 UGUUUUGA m7a (m6a->m7a) -0.528 -0.88 -0.84

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
25337753 rs192131651 T T hsa-miR-3074-3p
10
 tTGATATAtcctt
 Disrupted
N
 -0.015
C hsa-miR-1265
hsa-miR-3171
14
10
 ttgatACATCCTt
ttgATACATCctt
 Created
Created
N
N
 -0.216
-0.118

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