SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_001004125 |
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Gene Symbol: | TUSC1 |
Description: | Homo sapiens tumor suppressor candidate 1 (TUSC1), mRNA. |
Gene Location: | chr9(-):25676386-25678856 |
Browse Associations |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr9:g.25676589T>G | TUSC1_E1_UTR_3 | SJHYPO046_D | Hypodiploid_ALL | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr9:g.25676628T>C | COSN5121199 | HX25T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4315 |
acaaaAAAGCGactagttt |
0 | CCGCUUUC | m6b | Created | no TS | -0.171000 |
-2.600000 |
|
hsa-miR-4790-5p |
acaaaAAAGCGActagttt |
0 | AUCGCUUU | m7b | Created | no TS | -0.283000 |
-2.080000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr9:g.25676995T>C | COSN6386212 | RK308_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4659a-5p |
ttgaaATGGCAaataaatc |
0 | CUGCCAUG | m6b | Created | no TS | -0.130000 | No effect | |
hsa-miR-4659b-5p |
ttgaaATGGCAAataaatc |
0 | UUGCCAUG | m7a | Created | no TS | -0.130000 | No effect | |
hsa-miR-4699-3p |
ttgaaatgGTAAATaaatc |
5 |
AAUUUACU | m6b | Disrupted | 0.015000 | no TS |
0.460000 |
|
hsa-miR-4776-3p |
ttgaaATGGCAAataaatc |
0 | CUUGCCAU | m7b | Created | no TS | -0.268000 | No effect | |
hsa-miR-5590-5p |
ttgaaATGGCAAataaatc |
2 |
UUGCCAUA | m7a | Created | -0.285000 | -0.416000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr9:g.25677214C>G | 10_18630 | 6408 | Breast cancer | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-186-5p |
tcagctATTCTTTcatatg |
2 |
CAAAGAAU | m7b | Disrupted | 0.007 | no TS |
0.21 |
|
hsa-miR-494 |
tcagctatTGTTTCAtatg |
1 |
UGAAACAU | m7a | Created | -0.071 | -0.094 |
-0.04 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr9:g.25677302T>- | ICGC_ssm_v2_85718 | HX13T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3148 |
tttttTTTTTCCtgtattt |
0 | UGGAAAAA | m7b | Disrupted | -0.052000 | -0.049000 |
0.490000 |
|
hsa-miR-4700-3p |
tttttttttTCCTGTattt |
0 | CACAGGAC | m6b | Disrupted | -0.141000 | -0.140000 |
1.570000 |
|
hsa-miR-5095 |
tttttttttCCTGTAttt |
0 | UUACAGGC | m6b | Created | NA | NA |
2.670000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr9:g.25677515A>C | COSN6386213 | RK308_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-548s |
cgcTTGGCCATccgcttgg |
8 |
AUGGCCAA | m8a | Disrupted | -0.208000 | -0.149000 |
0.170000 |
|
hsa-miR-658 |
cgcttggcCCTCCGCttgg |
0 | GGCGGAGG | m7b | Created | no TS | -0.215000 |
-0.170000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr9:g.25677668G>T | COSN14654011 | PCSI_0090_Pa_X | [pancreas][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-1229 |
gccgcagccGGTGAGAGgc |
0 | CUCUCACC | m8a | (m8a->m7a) | -0.058000 | no TS | No effect |
hsa-miR-4438 |
gccgcAGCCTGTGagaggc |
0 | CACAGGCU | m8a | Created | no TS | 0.000000 | No effect |
hsa-miR-513a-5p |
gccgcagCCTGTGAgaggc |
0 | UUCACAGG | m7b | Created | no TS | 0.000000 | No effect |
hsa-miR-604 |
gcCGCAGCCTgtgagaggc |
4 |
AGGCUGCG | m8a | (m7b->m8a) | 0.000000 | 0.000000 | No effect |
hsa-miR-1229 |
gccgcagccGGTGAGAGgc |
0 | CUCUCACC | m8a | (m8a->m7a) | -0.058000 | no TS | No effect |
hsa-miR-4438 |
gccgcAGCCTGTGagaggc |
0 | CACAGGCU | m8a | Created | no TS | 0.000000 | No effect |
hsa-miR-513a-5p |
gccgcagCCTGTGAgaggc |
0 | UUCACAGG | m7b | Created | no TS | 0.000000 | No effect |
hsa-miR-604 |
gcCGCAGCCTgtgagaggc |
4 |
AGGCUGCG | m8a | (m7b->m8a) | 0.000000 | 0.000000 | No effect |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
25676427 | rs79028168 | A | A |
hsa-miR-5590-5p |
2 |
TATGGCAtagtcc |
Disrupted |
N |
-0.285 |
G |
hsa-miR-122-3p |
1 |
tATGGCGTAgtcc |
Created |
N |
-0.586 |
|||
25677217 | rs12348 | A | A |
hsa-miR-186-5p hsa-miR-6507-5p |
1 1 |
tcagctATTCTTT tcagcTATTCTTt |
Disrupted Disrupted |
N N |
0.007 0.018 |
G |
hsa-miR-3133 hsa-miR-4773 |
1 2 |
tcagctGTTCTTT tcagCTGTTCTtt |
Created Created |
N N |
-0.023 -0.086 |
|||
25677302 | rs74174596 | - | T |
hsa-miR-3148 hsa-miR-4700-3p |
3 1 |
ttTTTTTCCtgta ttttttTCCTGTA |
Unknown Unknown |
N N |
-0.003 -0.001 |
- | |||||||||
25677302 | rs78145805 | T | T |
hsa-miR-3148 hsa-miR-4700-3p |
3 1 |
ttTTTTTCCtgta ttttttTCCTGTA |
Disrupted Disrupted |
N N |
-0.019 -0.141 |
C |
hsa-miR-4668-5p hsa-miR-5584-5p |
3 3 |
ttTTTTCCCtgta tttTTTCCCTgta |
Created Created |
N N |
-0.192 -0.179 |