SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001130918
Gene Symbol:	TTLL6
Description:	Homo sapiens tubulin tyrosine ligase-like family, member 6 (TTLL6), transcript variant 1, mRNA.
Gene Location:	chr17(-):46839592-46894469
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.48762550G>A			COSN6657596		CHC322T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1270	ttggtcttcATCTCCAaga	1	CUGGAGAU	m7b	(m6b->m7b)	-0.117000	-0.289000	No effect
hsa-miR-1273f	ttggtcttCATCTCCaaga	0	GGAGAUGG	m7a	Created	NA	NA	No effect
hsa-miR-139-3p	ttggtcttCGTCTCCaaga	0	GGAGACGC	m7a	Disrupted	NA	NA	0.020000
hsa-miR-143-3p	ttggtctTCATCTCcaaga	0	UGAGAUGA	m7b	Created	no TS	-0.153000	No effect
hsa-miR-3676-5p	ttggtcttcATCTCCaaga	0	AGGAGAUC	m6b	Created	no TS	-0.113000	-0.010000
hsa-miR-4683	ttggtcttcATCTCCAaga	0	UGGAGAUC	m7a	(m6a->m7a)	no TS	-0.124000	-0.040000
hsa-miR-4770	ttggtctTCATCTCcaaga	0	UGAGAUGA	m7b	Created	no TS	-0.116000	No effect
hsa-miR-620	ttggtcttcATCTCCAaga	1	AUGGAGAU	m7b	(m6b->m7b)	-0.100000	-0.237000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.48762670A>G			COSN1197888		HCC98T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
48762550	rs2271890	A	G	hsa-miR-139-3p	0	gtcttCGTCTCCA	Created	N	-0.43
			A	hsa-miR-1270 hsa-miR-143-3p hsa-miR-4683 hsa-miR-4770 hsa-miR-6088 hsa-miR-620	0	gtcttcATCTCCA gtctTCATCTCca gtcttcATCTCCA gtctTCATCTCca gtctTCATCTCca gtcttcATCTCCA	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.172 -0.153 -0.124 -0.116 -0.125 -0.137

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