SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001145395
Gene Symbol:	TSEN2
Description:	Homo sapiens tRNA splicing endonuclease 2 homolog (S. cerevisiae) (TSEN2), transcript variant 2, mRNA.
Gene Location:	chr3(+):12526009-12572512
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.12530173T>C			COSN6748728		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-331-3p	tcCCAGGGGCatcgttgct	5	GCCCCUGG	m8a	(m7a->m8a)	-0.239000	-0.212000	1.210000
hsa-miR-4749-3p	tcccAGGGGCatcgttgct	0	CGCCCCUC	m6b	Created	no TS	-0.177000	-0.880000
hsa-miR-5195-5p	tcccAGGGGTatcgttgct	2	AACCCCUA	m6b	Disrupted	-0.188000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.12530237G>C			COSN9235383		AOCS-153-1-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5707	attcaCAAACGagtcaaaa	0	ACGUUUGA	m6b	Created	no TS	-0.162000	-4.600000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.12530576A>T			COSN5036721		HX32T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3121-3p	tacccTCTATTTtcatcct	0	UAAAUAGA	m7b	Created	no TS	0.045000	-2.350000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.12530953T>A			ICGC_718B49BA-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-335-3p	aatttataATGAAAAgagg	0	UUUUUCAU	m7b	Disrupted	-0.078	no TS	0.03
hsa-miR-4528	aattTATAATGAaaagagg	1	UCAUUAUA	m8a	Disrupted	-0.223	no TS	2.4

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
12530166	rs192884917	C	C	hsa-miR-204-3p hsa-miR-331-3p hsa-miR-4292 hsa-miR-4646-5p hsa-miR-4747-5p hsa-miR-5196-5p hsa-miR-6077 hsa-miR-6791-5p	2 5 3 2 2 2 2 3	ctcTTCCCAGggg ctcttcCCAGGGG ctcttCCCAGGGg ctcTTCCCAGggg ctCTTCCCAgggg ctCTTCCCAgggg CTCTTCCcagggg ctcttCCCAGGGg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N	-0.119 -0.239 -0.236 -0.119 -0.072 -0.069 -0.147 -0.282
			T	hsa-miR-1253 hsa-miR-125a-5p hsa-miR-125b-5p hsa-miR-4251 hsa-miR-4319 hsa-miR-4324 hsa-miR-5197-3p hsa-miR-6770-5p	2 3 3 2 3 2 2 2	cTCTTCTCAgggg ctcttCTCAGGGg ctcttCTCAGGGg ctcTTCTCAGggg ctcttCTCAGGGg ctctTCTCAGGgg CTCTTCTcagggg ctCTTCTCAgggg	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.201 -0.226 -0.235 -0.067 -0.245 -0.163 -0.097 -0.041
12530174	rs75787604	A	A	hsa-miR-5195-5p	2	AGGGGTAtcgttg	Disrupted	N	-0.188

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