SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001145394
Gene Symbol:	TSEN2
Description:	Homo sapiens tRNA splicing endonuclease 2 homolog (S. cerevisiae) (TSEN2), transcript variant 2, mRNA.
Gene Location:	chr3(+):12525930-12574820
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.12532784C>A			COSN8315967		TCGA-AN-A046-01		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3133	taaaaaGTTCTTTttgttg	1	UAAAGAAC	m7b	Disrupted	-0.160000	no TS	4.466000
hsa-miR-4511	taaaaAGTTCTTtttgttg	1	GAAGAACU	m7b	Disrupted	-0.214000	no TS	6.920000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.12532875A>G			COSN1912327		RK019_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-19a-3p	agataaaTTGCACAaggga	0	UGUGCAAA	m7a	Created	no TS	-0.134000	-5.080000
hsa-miR-19b-3p	agataaaTTGCACAaggga	0	UGUGCAAA	m7a	Created	no TS	-0.134000	-5.550000
hsa-miR-581	agataaattACACAAGgga	1	UCUUGUGU	m7b	(m7b->m6c)	-0.191000	no TS	0.010000
hsa-miR-19a-3p	agataaaTTGCACAaggga	0	UGUGCAAA	m7a	Created	no TS	-0.134000	-5.080000
hsa-miR-19b-3p	agataaaTTGCACAaggga	0	UGUGCAAA	m7a	Created	no TS	-0.134000	-5.550000
hsa-miR-581	agataaattACACAAGgga	1	UCUUGUGU	m7b	(m7b->m6c)	-0.191000	no TS	0.010000
hsa-miR-19a-3p	agataaaTTGCACAaggga	0	UGUGCAAA	m7a	Created	no TS	-0.134	-5.08
hsa-miR-19b-3p	agataaaTTGCACAaggga	0	UGUGCAAA	m7a	Created	no TS	-0.134	-5.55
hsa-miR-581	agataaattACACAAGgga	0	UCUUGUGU	m7b	(m7b->m6c)	-0.191	no TS	0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.12533086T>A			COSN5519655		RK088_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4495	tagTTTACATTtatacagt	4	AAUGUAAA	m8a	Disrupted	-0.085000	no TS	0.030000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
12532788	rs190411713	T	T	hsa-miR-3065-5p hsa-miR-3529-3p	2 2	ttcttTTTGTTGt ttctttTTGTTGT	Disrupted Disrupted	N N	-0.174 -0.205
			A	hsa-miR-186-5p hsa-miR-3133 hsa-miR-4803	1 1 2	TTCTTTAtgttgt TTCTTTAtgttgt ttctTTATGTTgt	Created Created Created	N N N	-0.033 -0.087 -0.095

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