SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_003286
Gene Symbol: TOP1
Description: Homo sapiens topoisomerase (DNA) I (TOP1), mRNA.
Gene Location: chr20(+):39657461-39753126
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr20:g.41123688A>C COSN1872088 RK126_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-183-5p gggtttTGCCATAacttct
 0 UAUGGCAC m7a Created no TS -0.144000 -10.120000
hsa-miR-25-3p gggtttTGCAATaacttct
 20
 CAUUGCAC m6b Disrupted -0.085000 no TS 5.160000
hsa-miR-32-5p gggtttTGCAATAacttct
 20
 UAUUGCAC m7a Disrupted -0.099000 no TS 0.010000
hsa-miR-363-3p gggtttTGCAATaacttct
 20
 AAUUGCAC m6b Disrupted -0.088000 no TS 5.940000
hsa-miR-367-3p gggtttTGCAATaacttct
 20
 AAUUGCAC m6b Disrupted -0.085000 no TS 1.590000
hsa-miR-518a-5p gggtTTTGCAataacttct
 20
 CUGCAAAG m6b Disrupted -0.047000 no TS 0.060000
hsa-miR-527 gggtTTTGCAataacttct
 20
 CUGCAAAG m6b Disrupted -0.047000 no TS 0.060000
hsa-miR-548aj-5p gggTTTTGCAataacttct
 20
 UGCAAAAG m7a (m7a->m6a) -0.034000 no TS No effect
hsa-miR-548aw gggTTTTGCAataacttct
 20
 GUGCAAAA m7b (m7b->m6b) -0.126000 no TS 1.240000
hsa-miR-548g-5p gggTTTTGCAataacttct
 20
 UGCAAAAG m7a (m7a->m6a) -0.034000 no TS No effect
hsa-miR-548x-5p gggTTTTGCAataacttct
 20
 UGCAAAAG m7a (m7a->m6a) -0.034000 no TS No effect
hsa-miR-92a-3p gggtttTGCAATAacttct
 20
 UAUUGCAC m7a Disrupted -0.092000 no TS 9.210000
hsa-miR-92b-3p gggtttTGCAATAacttct
 20
 UAUUGCAC m7a Disrupted -0.092000 no TS 7.910000
hsa-miR-183-5p gggtttTGCCATAacttct
 0 UAUGGCAC m7a Created no TS -0.144 -10.12
hsa-miR-25-3p gggtttTGCAATaacttct
 20
 CAUUGCAC m6b Disrupted -0.085 no TS 5.16
hsa-miR-32-5p gggtttTGCAATAacttct
 20
 UAUUGCAC m7a Disrupted -0.099 no TS 0.01
hsa-miR-363-3p gggtttTGCAATaacttct
 20
 AAUUGCAC m6b Disrupted -0.088 no TS 5.94
hsa-miR-367-3p gggtttTGCAATaacttct
 20
 AAUUGCAC m6b Disrupted -0.085 no TS 1.59
hsa-miR-518a-5p gggtTTTGCAataacttct
 20
 CUGCAAAG m6b Disrupted -0.047 no TS 0.06
hsa-miR-527 gggtTTTGCAataacttct
 20
 CUGCAAAG m6b Disrupted -0.047 no TS 0.06
hsa-miR-548aj-5p gggTTTTGCAataacttct
 20
 UGCAAAAG m7a (m7a->m6a) -0.034 no TS No effect
hsa-miR-548aw gggTTTTGCAataacttct
 20
 GUGCAAAA m7b (m7b->m6b) -0.126 no TS 1.24
hsa-miR-548g-5p gggTTTTGCAataacttct
 20
 UGCAAAAG m7a (m7a->m6a) -0.034 no TS No effect
hsa-miR-548x-5p gggTTTTGCAataacttct
 20
 UGCAAAAG m7a (m7a->m6a) -0.034 no TS No effect
hsa-miR-92a-3p gggtttTGCAATAacttct
 20
 UAUUGCAC m7a Disrupted -0.092 no TS 9.21
hsa-miR-92b-3p gggtttTGCAATAacttct
 20
 UAUUGCAC m7a Disrupted -0.092 no TS 7.91

Mutation Mutation ID Sample Name Cancer Type
chr20:g.41123690T>C COSN1872089 RK126_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-25-3p gtttTGCAATaacttctat
 20
 CAUUGCAC m6b Disrupted -0.085000 no TS 5.430000
hsa-miR-32-5p gtttTGCAATAacttctat
 20
 UAUUGCAC m7a Disrupted -0.099000 no TS 0.010000
hsa-miR-363-3p gtttTGCAATaacttctat
 20
 AAUUGCAC m6b Disrupted -0.088000 no TS 5.940000
hsa-miR-367-3p gtttTGCAATaacttctat
 20
 AAUUGCAC m6b Disrupted -0.085000 no TS 1.860000
hsa-miR-382-5p gttttgcaACAACTTCtat
 20
 GAAGUUGU m8a Created -0.584000 -0.709000 No effect
hsa-miR-4670-3p gttttgcaaTAACTTCtat
 20
 UGAAGUUA m7b (m7b->m6c) -0.160000 no TS 0.080000
hsa-miR-4684-3p gttTTGCAACAacttctat
 0 UGUUGCAA m8a Created no TS -0.300000 -2.150000
hsa-miR-744-3p gttttGCAACAacttctat
 0 CUGUUGCC m6b Created no TS -0.135000 -1.880000
hsa-miR-92a-3p gtttTGCAATAacttctat
 20
 UAUUGCAC m7a Disrupted -0.092000 no TS 9.480000
hsa-miR-92b-3p gtttTGCAATAacttctat
 20
 UAUUGCAC m7a Disrupted -0.092000 no TS 8.180000
hsa-miR-25-3p gtttTGCAATaacttctat
 20
 CAUUGCAC m6b Disrupted -0.085 no TS 5.43
hsa-miR-32-5p gtttTGCAATAacttctat
 20
 UAUUGCAC m7a Disrupted -0.099 no TS 0.01
hsa-miR-363-3p gtttTGCAATaacttctat
 20
 AAUUGCAC m6b Disrupted -0.088 no TS 5.94
hsa-miR-367-3p gtttTGCAATaacttctat
 20
 AAUUGCAC m6b Disrupted -0.085 no TS 1.86
hsa-miR-382-5p gttttgcaACAACTTCtat
 0 GAAGUUGU m8a Created -0.584 -0.709 No effect
hsa-miR-4670-3p gttttgcaaTAACTTCtat
 0 UGAAGUUA m7b (m7b->m6c) -0.16 no TS 0.08
hsa-miR-4684-3p gttTTGCAACAacttctat
 0 UGUUGCAA m8a Created no TS -0.3 -2.15
hsa-miR-744-3p gttttGCAACAacttctat
 0 CUGUUGCC m6b Created no TS -0.135 -1.88
hsa-miR-92a-3p gtttTGCAATAacttctat
 20
 UAUUGCAC m7a Disrupted -0.092 no TS 9.48
hsa-miR-92b-3p gtttTGCAATAacttctat
 20
 UAUUGCAC m7a Disrupted -0.092 no TS 8.18

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
41123483 rs147051331 A A hsa-miR-382-5p
hsa-miR-3912-5p
hsa-miR-495-5p
20
20
20
 tggACAACTTAtt
TGGACAActtatt
tggaCAACTTAtt
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.25
-0.168
-0.09
G hsa-miR-320e
20
 tggaCAGCTTAtt
 Created
N
 -0.123
41123696 rs3180629 C C hsa-miR-4670-3p
20
 TAACTTCtatatt
 Disrupted
N
 -0.16
T hsa-miR-3163
hsa-miR-548at-5p
hsa-miR-548az-5p
hsa-miR-548n
hsa-miR-548t-5p
20
20
20
20
20
 taacTTTTATAtt
TAACTTTtatatt
taACTTTTAtatt
taACTTTTAtatt
taACTTTTAtatt
 Created
Created
Created
Created
Created
N
N
N
N
N
 0.053
-0.104
-0.008
-0.003
-0.008

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