SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_152588
Gene Symbol:	TMTC2
Description:	Homo sapiens transmembrane and tetratricopeptide repeat containing 2 (TMTC2), mRNA.
Gene Location:	chr12(+):83080933-83528067
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.83132732T>C			0_408				Lung cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4803	aaaTTATGTTgttccttaa	0	UAACAUAA	m7b	(m7b->m6b)	-0.39	-0.303	0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.83132804C>T			COSN15489303		AOCS-135-8-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4655-3p	taagtgttACGAGGGagtg	0	ACCCUCGU	m7b	Disrupted	-0.497000	no TS	0.020000
hsa-miR-4655-3p	taagtgttACGAGGGagtg	0	ACCCUCGU	m7b	Disrupted	-0.497000	no TS	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.83133190A>G			COSN6537578		ICGC_MB76		[central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-186-5p	attgtattaATTCTTTtga	0	CAAAGAAU	m7b	(m7b->m6c)	0.061000	0.055000	-0.610000
hsa-miR-3129-3p	attgtATTAGTTcttttga	0	AAACUAAU	m7b	Created	no TS	-0.033000	-0.090000
hsa-miR-3133	attgtattaGTTCTTTtga	8	UAAAGAAC	m7b	(m6c->m7b)	-0.048000	-0.100000	-0.040000
hsa-miR-4511	attgtattAGTTCTTttga	8	GAAGAACU	m7b	Created	-0.043000	-0.146000	No effect
hsa-miR-5583-5p	attgtATTAGTTcttttga	0	AAACUAAU	m7b	Created	no TS	-0.043000	-0.860000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.83133935A>C			COSN8541820		tumor_4163639		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3929	tatatgaTCAGCCTCtcca	2	GAGGCUGA	m8a	Disrupted	-0.193000	no TS	2.850000
hsa-miR-4419b	tatatgaTCAGCCTCtcca	2	GAGGCUGA	m8a	Disrupted	-0.193000	no TS	4.960000
hsa-miR-4478	tatatgaTCAGCCTCtcca	2	GAGGCUGA	m8a	Disrupted	-0.166000	no TS	6.780000
hsa-miR-485-5p	tatatgatCAGCCTCTcca	2	AGAGGCUG	m8a	Disrupted	-0.228000	no TS	11.590000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
83132729	rs142307586	T	T	hsa-miR-4803	0	aaaTTATGTTgtt	Disrupted	N	-0.087
			G	hsa-miR-4714-3p hsa-miR-4735-5p	0	aaatTAGGTTGtt AAATTAGgttgtt	Created Created	N N	-0.212 -0.048
83132731	rs74106073	T	T	hsa-miR-4803	0	aTTATGTTgttcc	Disrupted	N	-0.087
83132805	rs139849298	-	G	hsa-miR-4469 hsa-miR-4655-3p hsa-miR-6803-3p	0	tgttacGAGGGAG tgttACGAGGGAg tgttaCGAGGGAg	Unknown Unknown Unknown	N N N	-0.163 -0.497 -0.233
			C	hsa-miR-4292 hsa-miR-4308 hsa-miR-4490 hsa-miR-6791-5p hsa-miR-7113-3p	0	tgttaCCAGGGAg tgttaCCAGGGAg tgTTACCAGggag tgttaCCAGGGAg tgttacCAGGGAG	Unknown Unknown Unknown Unknown Unknown	N N N N N	-0.152 -0.162 -0.09 -0.138 -0.173
83133190	rs150766698	A	A	hsa-miR-186-5p hsa-miR-374c-5p hsa-miR-655-3p	4 8 8	gtattaATTCTTT GTATTAAttcttt GTATTAAttcttt	Disrupted Disrupted Disrupted	N N N	0.006 -0.038 -0.036
			G	hsa-miR-3129-3p hsa-miR-3133 hsa-miR-4511 hsa-miR-5583-5p	8 4 4 8	gtATTAGTTcttt gtattaGTTCTTT gtattAGTTCTTt gtATTAGTTcttt	Created Created Created Created	N N N N	-0.033 -0.052 -0.103 -0.043

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