SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_138788
Gene Symbol:	TMEM45B
Description:	Homo sapiens transmembrane protein 45B (TMEM45B), mRNA.
Gene Location:	chr11(+):129685740-129729898
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.129858695C>T			COSN8215831		PCSI_0305_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1470	gccgagatgCGGAGGGCgc	0	GCCCUCCG	m8a	(m8a->m7b)	0.000000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.129859604G>A			ICGC_855B7E42-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.129859645C>T			COSN5899456		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-193b-5p	tggtgAAACCCCGtctcta	2	CGGGGUUU	m8a	Disrupted	-0.110000	no TS	2.740000
hsa-miR-483-5p	tggtgaaacCCCGTCTcta	2	AAGACGGG	m7b	(m7b->m6c)	-0.226000	no TS	0.270000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.129859783T>C			COSN4896750		CPCG_0183_Pr_P_P3		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-143-5p	atgccACTGCACtccagcc	0	GGUGCAGU	m7b	Created	-0.322000	-0.439000	-0.040000
hsa-miR-5693	atGCCACTGCactccagcc	2	GCAGUGGC	m8a	(m7a->m8a)	-0.214000	-0.187000	No effect
hsa-miR-143-5p	atgccACTGCACtccagcc	0	GGUGCAGU	m7b	Created	-0.322	-0.439	-0.04
hsa-miR-5693	atGCCACTGCactccagcc	0	GCAGUGGC	m8a	(m7a->m8a)	-0.214	-0.187	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
129858698	rs148552079	A	A	hsa-miR-1470 hsa-miR-4290	0	atgCGGAGGGcgc atgcGGAGGGCgc	Disrupted Disrupted	N N	No Change No Change
129859646	rs111573826	C	C	hsa-miR-193b-5p hsa-miR-483-5p	2 2	gAAACCCCgtctc gaaacCCCGTCTc	Disrupted Disrupted	N N	-0.11 -0.226
			A	hsa-miR-29b-2-5p hsa-miR-6863	2 2	GAAACCAcgtctc gaaacCACGTCTc	Created Created	N N	-0.097 -0.213

Genome Browser