SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001136103
Gene Symbol:	TMEM132C
Description:	Homo sapiens transmembrane protein 132C (TMEM132C), mRNA.
Gene Location:	chr12(+):128751947-129192460
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.128706674A>G			COSN6408335		HX36T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2115-3p	tatatTTCTGATaaaggag	0	CAUCAGAA	m7b	Created	no TS	-0.254000	No effect
hsa-miR-361-5p	tatattTCTGATAAaggag	0	UUAUCAGA	m8a	Created	no TS	-0.306000	-1.460000
hsa-miR-374a-3p	tatatttCTGATAAaggag	0	CUUAUCAG	m7b	Created	no TS	-0.239000	-1.440000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.128707303G>C			COSN8700589		AOCS-061-1-8		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.128707367C>T			COSN1562780		RK148_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-497-3p	gggctTGGTTTatcacaag	0	CAAACCAC	m6b	Created	no TS	0.009000	-0.670000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.128707504A>G			COSN7316474		8066491		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3136-5p	agattgTCAGTCAactgtg	0	CUGACUGA	m7b	Created	no TS	-0.281000	-7.810000
hsa-miR-4439	agattgTCAGTCAactgtg	0	GUGACUGA	m7b	Created	no TS	-0.271000	-3.190000
hsa-miR-4513	agattGTCAGTCaactgtg	0	AGACUGAC	m7b	Created	no TS	-0.376000	-8.790000
hsa-miR-888-3p	agatTGTCAGTCaactgtg	2	GACUGACA	m8a	Created	-0.116000	-0.318000	-0.230000
hsa-miR-943	agattgtCAGTCAactgtg	0	CUGACUGU	m6b	Created	no TS	-0.110000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.128707614C>T			COSN5713880		HX18T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3179	aagCCCCTTCgtgatcacc	3	AGAAGGGG	m7b	(m7b->m6b)	-0.202000	no TS	3.580000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.128707639G>A			COSN4727754		tumor_4127766		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4531	cagTTCTCCATgtgctcca	0	AUGGAGAA	m8a	Created	no TS	-0.062000	-0.050000
hsa-miR-4717-3p	cagttctCCATGTGctcca	0	ACACAUGG	m7b	Created	no TS	-0.147000	-0.210000
hsa-miR-4802-3p	cagttcTCCATGTgctcca	0	UACAUGGA	m7b	Created	no TS	-0.080000	-0.460000
hsa-miR-5589-3p	cagttctcCATGTGCtcca	0	UGCACAUG	m7b	Created	no TS	-0.106000	-0.080000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.128707697G>A			COSN7611086		PCSI_0164_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-658	atgctCTCCGCaggggggc	0	GGCGGAGG	m6b	Disrupted	-0.162000	no TS	5.430000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.128707811G>A			0_396				Melanoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1305	tggacctTTGAAAAatata	6	UUUUCAAC	m7a	Disrupted	0.006	no TS	0.02
hsa-miR-335-3p	tggaccttTGAAAAAtata	7	UUUUUCAU	m7a	Disrupted	0.001	no TS	-0.01
hsa-miR-548m	tggACCTTTGaaaaatata	8	CAAAGGUA	m7a	(m7a->m6a)	no TS	-0.101	0.9
hsa-miR-607	tggaccTTTGAAaaatata	6	GUUCAAAU	m6b	Disrupted	0.011	no TS	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
128707696	rs180888188	C	C	hsa-miR-5739 hsa-miR-658	2 4	gCTCTCCGcaggg gctCTCCGCAggg	Disrupted Disrupted	N N	-0.204 -0.162
			T	hsa-miR-2467-3p hsa-miR-3158-5p hsa-miR-3678-3p	4 21 4	gctCTCTGCAggg gctcTCTGCAGgg gctCTCTGCAggg	Created Created Created	N N N	-0.063 -0.047 -0.079

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