SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_052907
Gene Symbol: TMEM132B
Description: Homo sapiens transmembrane protein 132B (TMEM132B), mRNA.
Gene Location: chr12(+):125811161-126143589
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr12:g.125654889G>C COSN14506609 8070208 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr12:g.125655227A>T COSN9082444 8051728 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p acctctggaATTCTTTttg
 6
 CAAAGAAU m7b (m7b->m6c) 0.009000 no TS 0.160000
hsa-miR-3180-5p accTCTGGAAttctttttg
 6
 CUUCCAGA m7b (m7b->m6b) -0.333000 -0.256000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.125656488C>G 0_395 Lung cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1208 gtttgggAACAGTGctgaa
 7
 UCACUGUU m7b Disrupted 0.196 0.094 0.24
hsa-miR-1236 gtttgGGAAGAGtgctgaa
 5
 CCUCUUCC m7b Created -0.066 -0.013 No effect
hsa-miR-642b-5p gtttGGGAACagtgctgaa
 1
 GGUUCCCU m6b Disrupted -0.043 -0.042 0.03

Mutation Mutation ID Sample Name Cancer Type
chr12:g.125656721G>C COSN1144192 HX4T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3130-3p gagtttGGTGCAGaggtag
 0 GCUGCACC m7b Disrupted -0.077000 0.039000 8.100000
hsa-miR-3619-3p gagttTGGTCCagaggtag
 0 GGGACCAU m6b Created no TS -0.033000 -0.160000
hsa-miR-378a-3p gagtttgGTCCAGaggtag
 2
 ACUGGACU m6b Created -0.024000 -0.030000 No effect
hsa-miR-378b gagtttgGTCCAGaggtag
 2
 ACUGGACU m6b Created -0.048000 -0.051000 No effect
hsa-miR-378c gagtttgGTCCAGaggtag
 2
 ACUGGACU m6b Created -0.024000 -0.030000 -0.010000
hsa-miR-378d gagtttgGTCCAGaggtag
 2
 ACUGGACU m6b Created -0.024000 -0.030000 No effect
hsa-miR-378e gagtttgGTCCAGaggtag
 2
 ACUGGACU m6b Created -0.024000 -0.030000 No effect
hsa-miR-378f gagtttgGTCCAGaggtag
 2
 ACUGGACU m6b Created -0.024000 -0.027000 No effect
hsa-miR-378h gagtttgGTCCAGaggtag
 2
 ACUGGACU m6b Created -0.020000 -0.026000 No effect
hsa-miR-378i gagtttgGTCCAGaggtag
 2
 ACUGGACU m6b Created -0.020000 -0.026000 No effect
hsa-miR-422a gagtttgGTCCAGaggtag
 2
 ACUGGACU m6b Created -0.020000 -0.026000 No effect
hsa-miR-4638-3p gagtttgGTCCAGaggtag
 2
 CCUGGACA m6b Created -0.023000 -0.028000 No effect
hsa-miR-4776-5p gagttTGGTCCAgaggtag
 0 GUGGACCA m7b Created no TS -0.050000 No effect
hsa-miR-518c-5p gagtttggTCCAGAGgtag
 3
 UCUCUGGA m7b Created 0.103000 0.157000 No effect
hsa-miR-3130-3p gagtttGGTGCAGaggtag
 0 GCUGCACC m7b Disrupted -0.077 0.039 8.1
hsa-miR-3619-3p gagttTGGTCCagaggtag
 0 GGGACCAU m6b Created no TS -0.033 -0.16
hsa-miR-378a-3p gagtttgGTCCAGaggtag
 0 ACUGGACU m6b Created -0.024 -0.03 No effect
hsa-miR-378b gagtttgGTCCAGaggtag
 0 ACUGGACU m6b Created -0.048 -0.051 No effect
hsa-miR-378c gagtttgGTCCAGaggtag
 0 ACUGGACU m6b Created -0.024 -0.03 -0.01
hsa-miR-378d gagtttgGTCCAGaggtag
 0 ACUGGACU m6b Created -0.024 -0.03 No effect
hsa-miR-378e gagtttgGTCCAGaggtag
 0 ACUGGACU m6b Created -0.024 -0.03 No effect
hsa-miR-378f gagtttgGTCCAGaggtag
 0 ACUGGACU m6b Created -0.024 -0.027 No effect
hsa-miR-378h gagtttgGTCCAGaggtag
 0 ACUGGACU m6b Created -0.02 -0.026 No effect
hsa-miR-378i gagtttgGTCCAGaggtag
 0 ACUGGACU m6b Created -0.02 -0.026 No effect
hsa-miR-422a gagtttgGTCCAGaggtag
 0 ACUGGACU m6b Created -0.02 -0.026 No effect
hsa-miR-4638-3p gagtttgGTCCAGaggtag
 0 CCUGGACA m6b Created -0.023 -0.028 No effect
hsa-miR-4776-5p gagttTGGTCCAgaggtag
 0 GUGGACCA m7b Created no TS -0.05 No effect
hsa-miR-518c-5p gagtttggTCCAGAGgtag
 0 UCUCUGGA m7b Created 0.103 0.157 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.125656892C>T COSN4701173 PD4107a [breast][NS][carcinoma][ductal_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-658 gatgaaCCTCCGCtgaaac
 1
 GGCGGAGG m7b Disrupted -0.146000 no TS 0.350000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.125656954G>A COSN7610432 PCSI_0311_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-200c-5p tggtaaaGTAAGACGttgg
 12
 CGUCUUAC m8a Created -0.107000 -0.123000 No effect
hsa-miR-550a-3p tggtaaaGTAAGACgttgg
 12
 UGUCUUAC m7b Created -0.103000 -0.091000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr12:g.125657118T>A COSN7610433 PCSI_0048_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4251 agtggtTTCTCAGcagggc
 3
 CCUGAGAA m7b Disrupted 0.179000 0.064000 0.140000
hsa-miR-4663 agtggtttCTCAGCagggc
 4
 AGCUGAGC m6b Disrupted -0.067000 -0.098000 0.150000
hsa-miR-539-5p agtggTTTCTCagcagggc
 0 GGAGAAAU m6b Disrupted 0.260000 0.100000 2.150000
hsa-miR-93-3p agtggtttcTCAGCAGggc
 1
 ACUGCUGA m7b (m7b->m6c) -0.056000 -0.111000 0.340000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.125657158C>T COSN1561174 RK001_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4422 aagATGCTTTTtgtgacaa
 0 AAAAGCAU m8a Created no TS 0.119000 -0.160000
hsa-miR-513b aagatgcttCTTGTGAcaa
 2
 UUCACAAG m7b (m7b->m6c) 0.037000 no TS 0.400000
hsa-miR-4422 aagATGCTTTTtgtgacaa
 0 AAAAGCAU m8a Created no TS 0.119 -0.16
hsa-miR-513b aagatgcttCTTGTGAcaa
 0 UUCACAAG m7b (m7b->m6c) 0.037 no TS 0.4

Mutation Mutation ID Sample Name Cancer Type
chr12:g.125657765T>A COSN8699281 AOCS-147-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3665 tgctcagaCACCTGCTgag
 6
 AGCAGGUG m8a Created -0.273000 -0.317000 No effect
hsa-miR-3934 tgctcagACACCTGctgag
 1
 UCAGGUGU m7b Created 0.053000 0.086000 No effect
hsa-miR-4294 tgctcAGACTCCtgctgag
 1
 GGGAGUCU m7b Disrupted 0.004000 0.007000 1.480000
hsa-miR-4433-3p tgctcagACTCCTGctgag
 1
 ACAGGAGU m7b Disrupted -0.057000 -0.120000 No effect
hsa-miR-4722-5p tgctcagaCTCCTGCtgag
 0 GGCAGGAG m7b Disrupted -0.233000 -0.205000 0.090000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.125658473T>A COSN5933652 RK128_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4636 gttttctaCACGAGTTacc
 0 AACUCGUG m8a Created no TS -0.299000 -1.070000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.125658697C>T 13_264 SJRB004_D Retinoblastoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4302 atgaaACACTGagtttttt
 0 CCAGUGUG m6b Created -0.033 -0.15 -0.02

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
125654887 rs184656890 C
C hsa-miR-3180-5p
hsa-miR-499b-5p
hsa-miR-520a-5p
hsa-miR-525-5p
0 ttaagTCTGGAAA
ttAAGTCTGgaaa
ttaagTCTGGAAa
ttaagTCTGGAAa
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.251
-0.173
-0.129
-0.129
125656082 rs12308814 C C hsa-miR-1286
hsa-miR-4722-5p
hsa-miR-491-3p
5
2
8
 cTCCTGCAtaatg
CTCCTGCAtaatg
ctccTGCATAAtg
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.081
-0.205
0.019
A hsa-miR-4433-3p
hsa-miR-4459
hsa-miR-4768-3p
hsa-miR-506-5p
hsa-miR-892c-5p
2
2
2
7
8
 CTCCTGAataatg
CTCCTGAataatg
CTCCTGAataatg
ctCCTGAATAatg
ctcCTGAATAatg
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.042
-0.019
-0.022
-0.105
0.036
125656307 rs183418941 G G hsa-miR-3977
2
 ccTGAAGCAgtgc
 Disrupted
N
 0.14
A hsa-miR-1208
hsa-miR-452-5p
hsa-miR-4676-3p
hsa-miR-892c-3p
2
2
2
2
 cctgaAACAGTGc
cctgAAACAGTgc
cctgAAACAGTgc
cctgAAACAGTgc
 Created
Created
Created
Created
N
N
N
N
 0.083
0.182
0.192
0.182
125656721 rs12823305 G G hsa-miR-3130-3p
hsa-miR-4793-3p
hsa-miR-767-5p
2
2
2
 tttGGTGCAGAgg
tttgGTGCAGAgg
ttTGGTGCAgagg
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.116
0.006
-0.014
125656722 rs12824741 C C hsa-miR-3130-3p
hsa-miR-4793-3p
hsa-miR-767-5p
2
2
2
 ttGGTGCAGAggt
ttgGTGCAGAggt
tTGGTGCAgaggt
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.116
0.006
-0.014
G hsa-miR-6800-3p
3
 ttggtgGAGAGGT
 Created
N
 -0.025
125656894 rs12823561 G G hsa-miR-658
hsa-miR-7846-3p
1
1
 aCCTCCGCtgaaa
acCTCCGCTgaaa
 Disrupted
Disrupted
N
N
 -0.146
-0.086
T hsa-miR-3942-3p
hsa-miR-4257
hsa-miR-6847-5p
1
1
1
 acctccTCTGAAA
acctCCTCTGAaa
accTCCTCTGAaa
 Created
Created
Created
N
N
N
 0.121
0.031
0.055
125658390 rs185041191 G G hsa-miR-584-3p
hsa-miR-642a-5p
hsa-miR-642b-5p
2
2
2
 gtgagGGAACTGt
gtGAGGGAActgt
gtgAGGGAACtgt
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.093
-0.074
-0.097
A hsa-miR-1238-3p
hsa-miR-670-3p
2
2
 gtGAGGAAActgt
gTGAGGAAActgt
 Created
Created
N
N
 -0.034
-0.103
125658551 rs114658704 A G hsa-miR-1226-5p
hsa-miR-3616-3p
hsa-miR-4446-3p
hsa-miR-4721
hsa-miR-6762-3p
hsa-miR-6829-5p
hsa-miR-93-3p
1
1
1
1
1
1
1
 tcagcaGCCCTCA
tcagcaGCCCTCA
tcagCAGCCCTca
tcagcAGCCCTCA
tcAGCAGCCctca
tcaGCAGCCCtca
TCAGCAGccctca
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 -0.232
-0.163
-0.194
-0.357
-0.179
-0.264
-0.111
A hsa-miR-296-3p
hsa-miR-628-5p
hsa-miR-6804-5p
1
1
2
 tcagCAACCCTca
TCAGCAAccctca
tcagcaACCCTCA
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.185
-0.103
-0.128

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