SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_006068
Gene Symbol: TLR6
Description: Homo sapiens toll-like receptor 6 (TLR6), mRNA.
Gene Location: chr4(-):38825328-38858438
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr4:g.38824147C>A COSN1296775 HCC118T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3649 aaacGGTCCCatgcgggaa
 2
 AGGGACCU m6b Disrupted -0.190000 no TS 0.090000
hsa-miR-4535 aaacGGTCCAatgcgggaa
 0 GUGGACCU m6b Created no TS -0.173000 -0.430000
hsa-miR-4776-5p aaacGGTCCAatgcgggaa
 0 GUGGACCA m6b Created no TS -0.166000 -2.360000
hsa-miR-3649 aaacGGTCCCatgcgggaa
 2
 AGGGACCU m6b Disrupted -0.190000 no TS 0.090000
hsa-miR-4535 aaacGGTCCAatgcgggaa
 0 GUGGACCU m6b Created no TS -0.173000 -0.430000
hsa-miR-4776-5p aaacGGTCCAatgcgggaa
 0 GUGGACCA m6b Created no TS -0.166000 -2.360000
hsa-miR-3649 aaacGGTCCCatgcgggaa
 0 AGGGACCU m6b Disrupted -0.19 no TS 0.09
hsa-miR-4535 aaacGGTCCAatgcgggaa
 0 GUGGACCU m6b Created no TS -0.173 -0.43
hsa-miR-4776-5p aaacGGTCCAatgcgggaa
 0 GUGGACCA m6b Created no TS -0.166 -2.36

Mutation Mutation ID Sample Name Cancer Type
chr4:g.38824192C>T COSN6830184 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-217 ttgtagatgTGCAGTAaaa
 0 UACUGCAU m7a (m6a->m7a) no TS -0.108000 -4.600000
hsa-miR-4418 ttgtagatgTGCAGTaaaa
 0 CACUGCAG m6b Created no TS -0.095000 -0.020000
hsa-miR-509-3-5p ttgtagatgTGCAGTAaaa
 0 UACUGCAG m7a (m6a->m7a) no TS -0.102000 -0.010000
hsa-miR-509-5p ttgtagatgTGCAGTAaaa
 0 UACUGCAG m7a (m6a->m7a) no TS -0.098000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr4:g.38824637T>G COSN5154907 PD4115a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1226-3p caacccCTGGTGAacagat
 0 UCACCAGC m7a Created no TS -0.064000 -5.470000
hsa-miR-1911-3p caaccCCTGGTGaacagat
 0 CACCAGGC m7a Created NA NA -6.090000
hsa-miR-421 caacccCTGTTGAacagat
 3
 AUCAACAG m7b Disrupted -0.065000 -0.053000 No effect
hsa-miR-4709-5p caacccCTGTTGaacagat
 2
 ACAACAGU m6b Disrupted -0.156000 -0.145000 0.010000
hsa-miR-4733-3p caaccCCTGGTGaacagat
 0 CCACCAGG m7b Created no TS -0.166000 -2.900000


Mutation Mutation ID Sample Name Cancer Type
chr4:g.38824771A>T COSN9789858 C0074T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr4:g.38824957G>A COSN8614582 SS6003317 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1228-3p aaattagccAGGTGTGgtg
 3
 UCACACCU m7b (m6b->m7b) 0.002000 0.039000 0.750000
hsa-miR-4794 aaatTAGCCAGgtgtggtg
 2
 UCUGGCUA m7b Created -0.001000 -0.036000 No effect
hsa-miR-664-5p aaatTAGCCAGgtgtggtg
 2
 ACUGGCUA m7b Created -0.001000 -0.073000 -0.030000
hsa-miR-941 aaattaGCCGGGTGtggtg
 1
 CACCCGGC m8a Disrupted -0.221000 no TS 2.820000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.38824981G>C ICGC_74E628E6-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1324 accCTGTCTGtactaaaaa
 0 CCAGACAG m7b (m7b->m6c) -0.223 -0.219 No effect
hsa-miR-411-5p accctgtcTCTACTAaaaa
 0 UAGUAGAC m7a Created no TS 0.015 -0.15
hsa-miR-4524a-3p accCTGTCTCtactaaaaa
 0 UGAGACAG m7b (m6c->m7b) no TS 0.011 No effect
hsa-miR-4524b-3p acCCTGTCTCtactaaaaa
 0 GAGACAGG m8a (m7b->m8a) -0.033 -0.033 No effect

Mutation Mutation ID Sample Name Cancer Type
chr4:g.38825722T>C COSN14928706 LP6007544-DNA_A01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-214-3p ggtagCCTGCTGTgcaaag
 0 ACAGCAGG m8a Created no TS 0.012000 -0.870000
hsa-miR-3619-5p ggtagCCTGCTGtgcaaag
 0 UCAGCAGG m7b Created no TS -0.016000 -0.620000
hsa-miR-4438 ggtAGCCTGTtgtgcaaag
 2
 CACAGGCU m7b (m7b->m6c) 0.026000 no TS 0.010000
hsa-miR-4690-5p ggtaGCCTGCTgtgcaaag
 4
 GAGCAGGC m7b Created -0.157000 -0.262000 -3.380000
hsa-miR-5003-5p ggtagccTGTTGTGcaaag
 0 UCACAACA m7b Disrupted -0.121000 -0.216000 0.010000
hsa-miR-761 ggtagCCTGCTGtgcaaag
 0 GCAGCAGG m7b Created no TS -0.007000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr4:g.38826167A>T COSN15271152 SM-4B295 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-377-3p ttgcagacaTGTGTGAggg
 0 AUCACACA m7b (m6b->m7b) no TS -0.037000 -0.070000
hsa-miR-4288 ttGCAGACAAgtgtgaggg
 0 UUGUCUGC m8a (m8a->m7b) -0.227000 -0.147000 0.060000
hsa-miR-4643 ttgcagaCATGTGTgaggg
 2
 GACACAUG m7b Created -0.071000 -0.095000 -0.180000
hsa-miR-4789-3p ttgcagacATGTGTGaggg
 2
 CACACAUA m7a Created -0.213000 -0.213000 No effect
hsa-miR-654-3p ttgCAGACATgtgtgaggg
 0 UAUGUCUG m7b (m6c->m7b) no TS -0.017000 -0.770000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.38826901A>T COSN9039901 AOCS-155-3-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-345-5p cagttaGAGTCAGCccagt
 0 GCUGACUC m8a Created no TS -0.192000 -0.050000
hsa-miR-4656 cagttagagTCAGCCCAgt
 1
 UGGGCUGA m8a (m7a->m8a) -0.162000 -0.377000 -0.010000
hsa-miR-4675 cagttagagACAGCCCagt
 1
 GGGGCUGU m7b (m7b->m6b) -0.388000 -0.167000 -0.900000
hsa-miR-4741 cagttagagACAGCCCagt
 1
 CGGGCUGU m7b (m7b->m6b) -0.377000 -0.164000 0.040000
hsa-miR-626 cagttagAGACAGCccagt
 0 AGCUGUCU m7b Disrupted -0.121000 0.033000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr4:g.38826945C>A COSN1083572 TCGA-AP-A059-01 [endometrium][NS][carcinoma][endometrioid_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1245b-3p atgttTCATCTGgggaact
 2
 UCAGAUGA m7b Disrupted -0.133000 no TS 0.450000
hsa-miR-2355-5p atgtttcatCTGGGGAact
 2
 AUCCCCAG m7b (m7b->m6b) -0.627000 -0.359000 3.830000
hsa-miR-1245b-3p atgttTCATCTGgggaact
 2
 UCAGAUGA m7b Disrupted -0.133000 no TS 0.450000
hsa-miR-2355-5p atgtttcatCTGGGGAact
 2
 AUCCCCAG m7b (m7b->m6b) -0.627000 -0.359000 3.830000
hsa-miR-1245b-3p atgttTCATCTGgggaact
 0 UCAGAUGA m7b Disrupted -0.133 no TS 0.45
hsa-miR-2355-5p atgtttcatCTGGGGAact
 0 AUCCCCAG m7b (m7b->m6b) -0.627 -0.359 3.83

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
38824857 rs142441314 A
A hsa-miR-199a-3p
hsa-miR-199b-3p
hsa-miR-3129-5p
hsa-miR-4473
hsa-miR-512-3p
hsa-miR-520f-3p
hsa-miR-626
hsa-miR-6876-3p
0 gacagcACTACTG
gacagcACTACTG
gacagcACTACTG
gacAGCACTActg
gaCAGCACTActg
gacAGCACTActg
GACAGCActactg
GACAGCActactg
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
 0.042
0.042
0.06
0.018
-0.099
0.002
-0.071
-0.074
38826895 rs34400891 - - hsa-miR-1587
hsa-miR-3620-5p
hsa-miR-378g
hsa-miR-4463
hsa-miR-4492
hsa-miR-4498
hsa-miR-4656
hsa-miR-4675
hsa-miR-4741
hsa-miR-5001-5p
hsa-miR-6829-5p
hsa-miR-762
hsa-miR-873-3p
1
1
1
1
1
1
1
1
1
1
1
1
5
 aCAGCCCAgtctc
aCAGCCCAgtctc
acAGCCCAGtctc
acagcCCAGTCTc
aCAGCCCAgtctc
aCAGCCCAgtctc
aCAGCCCAgtctc
ACAGCCCAgtctc
ACAGCCCAgtctc
aCAGCCCAgtctc
aCAGCCCAgtctc
aCAGCCCAgtctc
acagccCAGTCTC
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
N
N
N
N
N
N
 -0.224
-0.243
-0.191
-0.002
-0.145
-0.148
-0.162
-0.187
-0.186
-0.148
-0.16
-0.151
-0.007
C hsa-miR-185-3p
hsa-miR-4283
hsa-miR-4489
1
1
1
 aCAGCCCCAgtctc
acAGCCCCAgtctc
acAGCCCCAgtctc
 Unknown
Unknown
Unknown
N
N
N
 -0.451
-0.178
-0.202

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