SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_003255
Gene Symbol: TIMP2
Description: Homo sapiens TIMP metallopeptidase inhibitor 2 (TIMP2), mRNA.
Gene Location: chr17(-):76849058-76921472
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr17:g.78853252C>T COSN7456351 8050939 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-338-5p taaagtttATATTGTagtt
 0 AACAAUAU m7b Created no TS -0.184000 -0.770000
hsa-miR-4495 taaagTTTACATTgtagtt
 15
 AAUGUAAA m8a Disrupted -0.113000 no TS 1.860000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.78853886A>T COSN1729703 RK006_C02 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3165 tacaacTCCACCagacccc
 2
 AGGUGGAU m6b Disrupted -0.088000 no TS 0.380000
hsa-miR-4299 tacaactcCACCAGacccc
 9
 GCUGGUGA m6b Disrupted -0.042000 no TS 3.880000
hsa-miR-4456 tacaactCCACCAGacccc
 4
 CCUGGUGG m7b Disrupted -0.191000 no TS 4.740000
hsa-miR-516b-5p tacaactcCTCCAGAcccc
 0 AUCUGGAG m7b Created no TS -0.002000 -4.280000
hsa-miR-548q tacaactcCACCAGacccc
 9
 GCUGGUGC m6b Disrupted -0.054000 no TS 0.100000
hsa-miR-765 tacaaCTCCTCCAgacccc
 0 UGGAGGAG m8a Created no TS -0.196000 0.020000
hsa-miR-766-5p tacaacTCCTCCagacccc
 2
 AGGAGGAA m6b Created -0.021000 -0.080000 -5.460000
hsa-miR-3165 tacaacTCCACCagacccc
 0 AGGUGGAU m6b Disrupted -0.088 no TS 0.38
hsa-miR-4299 tacaactcCACCAGacccc
 0 GCUGGUGA m6b Disrupted -0.042 no TS 3.88
hsa-miR-4456 tacaactCCACCAGacccc
 0 CCUGGUGG m7b Disrupted -0.191 no TS 4.74
hsa-miR-516b-5p tacaactcCTCCAGAcccc
 0 AUCUGGAG m7b Created no TS -0.002 -4.28
hsa-miR-548q tacaactcCACCAGacccc
 0 GCUGGUGC m6b Disrupted -0.054 no TS 0.1
hsa-miR-765 tacaaCTCCTCCAgacccc
 0 UGGAGGAG m8a Created no TS -0.196 0.02
hsa-miR-766-5p tacaacTCCTCCagacccc
 0 AGGAGGAA m6b Created -0.021 -0.08 -5.46

Mutation Mutation ID Sample Name Cancer Type
chr17:g.78854628T>C COSN5420970 RK117_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1286 agccatcGTCCTGCAcggg
 3
 UGCAGGAC m8a Created -0.165000 -0.289000 -0.150000
hsa-miR-298 agccatcgTTCTGCacggg
 7
 AGCAGAAG m6b Disrupted -0.022000 -0.077000 No effect
hsa-miR-4436a agccatcGTCCTGCacggg
 3
 GCAGGACA m7a Created -0.046000 -0.046000 No effect
hsa-miR-4722-5p agccatcgTCCTGCacggg
 3
 GGCAGGAG m6b Created -0.135000 -0.140000 -0.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
78853683 rs139665208 T T hsa-miR-298
9
 ggtTTCTGCAtcg
 Disrupted
N
 -0.024
C hsa-miR-6850-5p
9
 ggtTTCCGCAtcg
 Created
N
 -0.209

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