SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001128148
Gene Symbol:	TFRC
Description:	Homo sapiens transferrin receptor (p90, CD71) (TFRC), transcript variant 2, mRNA.
Gene Location:	chr3(-):195776154-195809032
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.196049568A>G			COSN8365486		tumor_4163639		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2114-3p	aacAGGCTCGatattcctg	2	CGAGCCUC	m7a	(m6b->m7a)	-0.192000	no TS	0.110000
hsa-miR-4461	aacaggCTCAATattcctg	2	GAUUGAGA	m6b	Disrupted	-0.069000	no TS	0.210000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.196050368A>G			COSN1940073		RK010_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2276	tttagTTGCAGAaacattt	12	UCUGCAAG	m7a	Disrupted	-0.085000	-0.048000	0.060000
hsa-miR-4772-3p	tttaGTTGCAGaaacattt	11	CCUGCAAC	m7b	Disrupted	-0.444000	-0.263000	0.050000
hsa-miR-544a	tttagtTGCAGAAacattt	10	AUUCUGCA	m7b	Disrupted	-0.101000	no TS	1.930000
hsa-miR-718	tttagttGCGGAAacattt	0	CUUCCGCC	m6b	Created	no TS	-0.143000	-1.560000
hsa-miR-2276	tttagTTGCAGAaacattt	12	UCUGCAAG	m7a	Disrupted	-0.085000	-0.048000	0.060000
hsa-miR-4772-3p	tttaGTTGCAGaaacattt	11	CCUGCAAC	m7b	Disrupted	-0.444000	-0.263000	0.050000
hsa-miR-544a	tttagtTGCAGAAacattt	10	AUUCUGCA	m7b	Disrupted	-0.101000	no TS	1.930000
hsa-miR-718	tttagttGCGGAAacattt	0	CUUCCGCC	m6b	Created	no TS	-0.143000	-1.560000
hsa-miR-2276	tttagTTGCAGAaacattt	0	UCUGCAAG	m7a	Disrupted	-0.085	-0.048	0.06
hsa-miR-4772-3p	tttaGTTGCAGaaacattt	0	CCUGCAAC	m7b	Disrupted	-0.444	-0.263	0.05
hsa-miR-544a	tttagtTGCAGAAacattt	0	AUUCUGCA	m7b	Disrupted	-0.101	no TS	1.93
hsa-miR-718	tttagttGCGGAAacattt	0	CUUCCGCC	m6b	Created	no TS	-0.143	-1.56

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.196051343T>A			COSN6760872		RK187_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
196049565	rs186269975	A	A	hsa-miR-4461	2	CTCAATAttcctg	Disrupted	N	-0.069
			G	hsa-miR-873-5p	6	ctcaatGTTCCTG	Created	N	-0.257
196050365	rs1050254	A	A	hsa-miR-33a-3p hsa-miR-544a hsa-miR-6738-3p	11 10 11	tgcagAAACATTt TGCAGAAAcattt tGCAGAAAcattt	Disrupted Disrupted Disrupted	N N N	0.111 -0.101 -0.024
			C	hsa-miR-346 hsa-miR-4288 hsa-miR-4711-3p hsa-miR-632	11 11 10 11	tGCAGACAcattt tGCAGACAcattt tgcAGACACAttt tGCAGACAcattt	Created Created Created Created	N N N N	-0.085 -0.103 -0.042 -0.131

Genome Browser