SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_005423
Gene Symbol:	TFF2
Description:	Homo sapiens trefoil factor 2 (TFF2), mRNA.
Gene Location:	chr21(-):43766466-43771208
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr21:g.42346451C>T			COSN15314850		SNUH_G76_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4517	agctTCATATTTcatgaaa	0	AAAUAUGA	m8a	Created	no TS	-0.086000	-5.300000
hsa-miR-548ao-5p	agcttcaTACTTCatgaaa	0	AGAAGUAA	m6b	Disrupted	-0.078000	no TS	1.560000
hsa-miR-548ax	agcttcaTACTTCatgaaa	0	AGAAGUAA	m6b	Disrupted	-0.078000	no TS	0.440000
hsa-miR-4517	agctTCATATTTcatgaaa	0	AAAUAUGA	m8a	Created	no TS	-0.086000	-5.300000
hsa-miR-548ao-5p	agcttcaTACTTCatgaaa	0	AGAAGUAA	m6b	Disrupted	-0.078000	no TS	1.560000
hsa-miR-548ax	agcttcaTACTTCatgaaa	0	AGAAGUAA	m6b	Disrupted	-0.078000	no TS	0.440000
hsa-miR-4517	agctTCATATTTcatgaaa	0	AAAUAUGA	m8a	Created	no TS	-0.086000	-5.300000
hsa-miR-548ao-5p	agcttcaTACTTCatgaaa	0	AGAAGUAA	m6b	Disrupted	-0.078000	no TS	1.560000
hsa-miR-548ax	agcttcaTACTTCatgaaa	0	AGAAGUAA	m6b	Disrupted	-0.078000	no TS	0.440000
hsa-miR-4517	agctTCATATTTcatgaaa	0	AAAUAUGA	m8a	Created	no TS	-0.086	-5.3
hsa-miR-548ao-5p	agcttcaTACTTCatgaaa	0	AGAAGUAA	m6b	Disrupted	-0.078	no TS	1.56
hsa-miR-548ax	agcttcaTACTTCatgaaa	0	AGAAGUAA	m6b	Disrupted	-0.078	no TS	0.44

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
42346451	rs225334	T	C	hsa-miR-548ao-5p hsa-miR-548ax hsa-miR-5585-5p hsa-miR-8060	1 1 1 0	ttcaTACTTCAtg ttcaTACTTCAtg ttcaTACTTCAtg ttcataCTTCATG	Created Created Created Created	N N N N	-0.078 -0.078 -0.098 -0.233
			T	hsa-miR-4517	0	tTCATATTtcatg	Disrupted	N	-0.086

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