SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_024665
Gene Symbol: TBL1XR1
Description: Homo sapiens transducin (beta)-like 1 X-linked receptor 1 (TBL1XR1), mRNA.
Gene Location: chr3(-):176738541-176915048
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr3:g.177020924G>T COSN6755228 RK059_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr3:g.177022576G>A COSN15407948 0067_CRUK_PC_0067_T1_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.177023231T>A COSN5528909 RK307_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-105-5p gtgatGCATTTGtcaattg
 1
 UCAAAUGC m7b Disrupted -0.029000 -0.027000 0.030000
hsa-miR-489 gtgatgcatATGTCAattg
 0 GUGACAUC m6b Created -0.001000 0.043000 -0.240000
hsa-miR-5580-3p gtgatgCATATGTcaattg
 6
 CACAUAUG m7b Created 0.188000 0.297000 -0.010000
hsa-miR-5700 gtgATGCATTtgtcaattg
 12
 UAAUGCAU m7b (m7b->m6c) -0.095000 -0.176000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.177023414A>G COSN1933059 RK007_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-488-5p atgctgagTATCTGGcact
 15
 CCCAGAUA m7b Disrupted 0.041000 no TS 0.030000
hsa-miR-512-5p atGCTGAGTGtctggcact
 13
 CACUCAGC m8a (m7b->m8a) -0.108000 -0.064000 0.050000
hsa-miR-488-5p atgctgagTATCTGGcact
 0 CCCAGAUA m7b Disrupted 0.041 no TS 0.03
hsa-miR-512-5p atGCTGAGTGtctggcact
 0 CACUCAGC m8a (m7b->m8a) -0.108 -0.064 0.05

Mutation Mutation ID Sample Name Cancer Type
chr3:g.177023535A>C COSN1933060 RK141_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023000 -0.380000
hsa-let-7b-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023000 -0.010000
hsa-let-7c aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023000 -0.030000
hsa-let-7d-5p aaaattTACCTCaagagag
 0 AGAGGUAG m6b Created no TS -0.023000 -0.570000
hsa-let-7e-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023000 -0.920000
hsa-let-7f-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023000 -0.060000
hsa-let-7g-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.026000 -0.630000
hsa-let-7i-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.026000 -0.040000
hsa-miR-202-3p aaaattTACCTCaagagag
 0 AGAGGUAU m6b Created no TS -0.024000 -0.010000
hsa-miR-3171 aaaattTACATCaagagag
 0 AGAUGUAU m6b Disrupted 0.012000 no TS No effect
hsa-miR-4458 aaaattTACCTCaagagag
 0 AGAGGUAG m6b Created no TS -0.023000 -0.270000
hsa-miR-4495 aaaaTTTACATcaagagag
 0 AAUGUAAA m7b Disrupted 0.059000 no TS No effect
hsa-miR-4500 aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.026000 -1.300000
hsa-miR-526b-5p aaaatttacCTCAAGAGag
 0 CUCUUGAG m8a (m7a->m8a) 0.034000 0.082000 -0.020000
hsa-miR-98 aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023000 -0.030000
hsa-let-7a-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023 -0.38
hsa-let-7b-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023 -0.01
hsa-let-7c aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023 -0.03
hsa-let-7d-5p aaaattTACCTCaagagag
 0 AGAGGUAG m6b Created no TS -0.023 9.82
hsa-let-7e-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023 -0.92
hsa-let-7f-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023 -0.06
hsa-let-7g-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.026 -0.63
hsa-let-7i-5p aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.026 -0.04
hsa-miR-202-3p aaaattTACCTCaagagag
 0 AGAGGUAU m6b Created no TS -0.024 -0.01
hsa-miR-3171 aaaattTACATCaagagag
 0 AGAUGUAU m6b Disrupted 0.012 no TS No effect
hsa-miR-4458 aaaattTACCTCaagagag
 0 AGAGGUAG m6b Created no TS -0.023 -0.27
hsa-miR-4495 aaaaTTTACATcaagagag
 0 AAUGUAAA m7b Disrupted 0.059 no TS No effect
hsa-miR-4500 aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.026 -1.3
hsa-miR-526b-5p aaaatttacCTCAAGAGag
 0 CUCUUGAG m8a (m7a->m8a) 0.034 0.082 -0.02
hsa-miR-98 aaaattTACCTCAagagag
 0 UGAGGUAG m7a Created no TS -0.023 -0.03

Mutation Mutation ID Sample Name Cancer Type
chr3:g.177023547T>C COSN7627395 PCSI_0356_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548c-3p ataatATTTTTaaaaattt
 14
 CAAAAAUC m6b Disrupted 0.896000 0.710000 No effect
hsa-miR-5680 ataatATTTCTaaaaattt
 0 GAGAAAUG m6b Created -0.059000 0.051000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.177024488T>C COSN15140785 LP6007404-DNA_A01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-451b tttgtttgTCTTGCTttgt
 14
 UAGCAAGA m7b Created -0.238000 -0.324000 -0.030000
hsa-miR-4696 tttgtttGTCTTGCtttgt
 0 UGCAAGAC m7b Created no TS -0.176000 -1.170000
hsa-miR-495 tttGTTTGTTTtgctttgt
 13
 AAACAAAC m8a Disrupted -0.007000 0.029000 No effect
hsa-miR-548p tttgtttgTTTTGCTttgt
 0 UAGCAAAA m7b Disrupted 0.278000 0.285000 0.040000
hsa-miR-5688 tttGTTTGTTttgctttgt
 13
 UAACAAAC m7b (m7b->m6c) -0.025000 0.030000 0.250000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.177024544T>C COSN7837226 8013912 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
177021097 rs188152558 A A hsa-miR-1322
hsa-miR-5680
16
16
 tGCATCATttctt
tgcatCATTTCTt
 Disrupted
Disrupted
N
N
 -0.212
-0.114
177023437 rs186314847 G G hsa-miR-155-3p
hsa-miR-3685
hsa-miR-6761-3p
20
20
7
 acttacGTAGGAA
acttacGTAGGAA
acttaCGTAGGAa
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.013
0.008
-0.117
A hsa-miR-202-5p
hsa-miR-337-3p
hsa-miR-379-3p
hsa-miR-380-3p
hsa-miR-411-3p
hsa-miR-4495
7
20
5
5
5
5
 acttaCATAGGAA
acttacATAGGAA
acTTACATAggaa
acTTACATAggaa
acTTACATAggaa
acTTACATAggaa
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.025
0.045
0.123
0.128
0.123
0.137
177024296 rs200310539 - - hsa-miR-548p
15
 TTTGCTAccttag
 Unknown
N
 0.048
T hsa-miR-548ag
hsa-miR-548ai
hsa-miR-548ba
hsa-miR-570-5p
15
15
15
15
 tttgcTTACCTTAg
tttgcTTACCTTAg
tttgcTTACCTTAg
tttgcTTACCTTAg
 Unknown
Unknown
Unknown
Unknown
N
N
N
N
 0.01
0.004
-0.01
0.004
177024299 rs13065151 G G hsa-miR-548p
15
 atgTTTGCTAcct
 Disrupted
N
 0.048
C hsa-miR-4261
hsa-miR-4496
hsa-miR-494-3p
hsa-miR-8065
16
15
16
15
 aTGTTTCCtacct
atGTTTCCTAcct
ATGTTTCctacct
atgtTTCCTACct
 Created
Created
Created
Created
N
N
N
N
 -0.076
-0.037
0.045
-0.096
177025034 rs7616373 C C hsa-miR-451b
15
 tttgtTCTTGCTt
 Disrupted
N
 -0.197
T hsa-miR-548p
15
 tttgtTTTTGCTt
 Created
N
 -0.118

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