SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_015093
Gene Symbol:	TAB2
Description:	Homo sapiens TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2), mRNA.
Gene Location:	chr6(+):149639435-149732747
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.149410340C>G			COSN14767686		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3170	gaaatACCCCAaagctttt	5	CUGGGGUU	m6b	Disrupted	-0.134000	no TS	6.470000
hsa-miR-4260	gaaataCCCCAAagctttt	8	CUUGGGGC	m6b	Disrupted	-0.099000	no TS	0.010000
hsa-miR-450a-3p	gaaataCCCCAAagctttt	8	AUUGGGGA	m6b	Disrupted	-0.106000	no TS	1.340000
hsa-miR-5572	gaaatACCCCAAagctttt	5	GUUGGGGU	m7b	Disrupted	-0.277000	no TS	2.080000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.149410601A>T			COSN8493805		J73_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1226-5p	tttGCCCTCAtgagttcca	7	GUGAGGGC	m7b	(m7b->m6b)	-0.202000	no TS	-0.730000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.149410610A>G			COSN6308338		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.149410888T>-			ICGC_ssm_v2_81557		HX13T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3613-3p	ctacagcccTTTTTTGga	0	ACAAAAAA	m7b	(m6c->m7b)	0.128000	0.176000	0.200000
hsa-miR-4446-3p	ctaCAGCCCTttttttgga	10	CAGGGCUG	m7b	(m7b->m6b)	-0.394000	-0.389000	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.149410903G>A			COSN9497051		AOCS-131-1-3		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-513a-3p	tggagaGAAATTTAaatgc	0	UAAAUUUC	m8a	Created	no TS	0.060000	-0.390000
hsa-miR-513c-3p	tggagaGAAATTTAaatgc	0	UAAAUUUC	m8a	Created	no TS	0.070000	-0.120000
hsa-miR-942	tggAGAGAAGtttaaatgc	4	UCUUCUCU	m7b	(m7b->m6b)	-0.051000	no TS	0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
149410340	rs7896	C	C	hsa-miR-3170 hsa-miR-4260 hsa-miR-450a-2-3p hsa-miR-5572 hsa-miR-6737-5p hsa-miR-6812-5p hsa-miR-6819-5p hsa-miR-6855-5p hsa-miR-6881-5p	7 8 8 7 7 7 7 7 5	atACCCCAAagct ataCCCCAAAgct ataCCCCAAAgct atACCCCAAAgct atACCCCAAagct atACCCCAAagct atACCCCAAagct atACCCCAAagct aTACCCCAaagct	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	-0.134 -0.099 -0.106 -0.277 -0.127 -0.12 -0.127 -0.144 -0.146

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