SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_003177
Gene Symbol:	SYK
Description:	Homo sapiens spleen tyrosine kinase (SYK), transcript variant 2, mRNA.
Gene Location:	chr9(+):93564011-93660842
Browse Associations
Browse Pathways

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.90896066G>A			COSN14793089		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4662a-5p	aatTTGGCTActtctacgg	0	UUAGCCAA	m7b	(m6b->m7b)	no TS	-0.143000	-0.200000
hsa-miR-548ao-5p	aatttggcTACTTCTacgg	0	AGAAGUAA	m7a	Created	NA	NA	-1.950000
hsa-miR-548ax	aatttggcTACTTCTacgg	0	AGAAGUAA	m7a	Created	NA	NA	-0.270000
hsa-miR-562	aatttgGCTACTTctacgg	0	AAAGUAGC	m7b	Created	no TS	-0.078000	-0.080000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.90896074G>A			COSN14782726		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.90896572A>G			COSN14753677		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1299	gagtTTCCAGAgaaagtat	3	UUCUGGAA	m7b	Created	0.043000	-0.018000	-0.390000
hsa-miR-3191-5p	gagtttCCAGAGAaagtat	0	CUCUCUGG	m7b	Created	no TS	-0.207000	-5.920000
hsa-miR-326	gagtttCCAGAGaaagtat	0	CCUCUGGG	m6b	Created	no TS	-0.064000	-6.740000
hsa-miR-330-5p	gagtttCCAGAGAaagtat	0	UCUCUGGG	m7a	Created	no TS	-0.067000	-0.130000
hsa-miR-4768-5p	gagtttccAGAGAAagtat	4	AUUCUCUC	m6b	Created	0.012000	0.049000	-4.910000
hsa-miR-518c-5p	gagttTCCAGAGAaagtat	2	UCUCUGGA	m8a	Created	-0.258000	-0.442000	-2.270000
hsa-miR-875-3p	gagTTTCCAGagaaagtat	0	CCUGGAAA	m7b	(m6b->m7b)	0.022000	-0.003000	-2.060000
hsa-miR-9-5p	gagtttCCAAAGAaagtat	3	UCUUUGGU	m7a	Disrupted	-0.001000	0.024000	1.810000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.90896785A>G			ICGC_81192D66-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-106b-5p	caGCACTTTAggaggccga	1	UAAAGUGC	m8a	(m8a->m7a)	0.057	0.077	0.06
hsa-miR-150-5p	cagcactTTGGGAGgccga	0	UCUCCCAA	m7b	Created	no TS	0.042	-0.03
hsa-miR-17-5p	caGCACTTTGggaggccga	1	CAAAGUGC	m8a	(m7a->m8a)	0.057	0.077	0.03
hsa-miR-186-3p	cagcaCTTTGGGaggccga	0	GCCCAAAG	m7b	Created	-0.012	0.041	-0.75
hsa-miR-20a-5p	caGCACTTTAggaggccga	1	UAAAGUGC	m8a	(m8a->m7a)	0.057	0.077	0.01
hsa-miR-20b-5p	caGCACTTTGggaggccga	1	CAAAGUGC	m8a	(m7a->m8a)	0.057	0.077	0.01
hsa-miR-519d	caGCACTTTGggaggccga	1	CAAAGUGC	m8a	(m7a->m8a)	0.046	0.067	0.01
hsa-miR-520g	cagCACTTTGggaggccga	0	ACAAAGUG	m7b	(m6b->m7b)	no TS	0.139	-2.88
hsa-miR-520h	cagCACTTTGggaggccga	0	ACAAAGUG	m7b	(m6b->m7b)	no TS	0.139	-2.9
hsa-miR-93-5p	caGCACTTTGggaggccga	1	CAAAGUGC	m8a	(m7a->m8a)	0.057	0.077	0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.90897086G>A			COSN9527495		AOCS-128-1-0		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3692-5p	atgCCAGCAGatataaata	0	CCUGCUGG	m7b	(m7b->m6b)	-0.184000	-0.086000	5.010000
hsa-miR-4686	atgccAGCAGATAtaaata	4	UAUCUGCU	m8a	Disrupted	-0.001000	-0.012000	0.200000
hsa-miR-93-3p	atgcCAGCAGatataaata	1	ACUGCUGA	m6b	Disrupted	-0.018000	no TS	2.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.90897474A>T			COSN2333347		RK032_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1255b-2-3p	agtttggtaAAGTGGTgac	2	AACCACUU	m7b	(m7b->m6c)	-0.042000	no TS	3.990000
hsa-miR-1255b-2-3p	agtttggtaAAGTGGTgac	0	AACCACUU	m7b	(m7b->m6c)	-0.042	no TS	3.99

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.90898029C>T			COSN14867368		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1254	attctcataTCCAGGCTgc	0	AGCCUGGA	m8a	(m7b->m8a)	-0.104000	-0.301000	-0.480000
hsa-miR-3116	attctcataTCCAGGCtgc	0	UGCCUGGA	m7b	(m6c->m7b)	-0.095000	-0.273000	No effect
hsa-miR-3201	attctCATATCCaggctgc	0	GGGAUAUG	m7b	Created	no TS	-0.188000	-4.820000
hsa-miR-4791	attctCATATCCAggctgc	0	UGGAUAUG	m8a	Created	no TS	-0.156000	-2.854000
hsa-miR-661	attctcataCCCAGGCtgc	2	UGCCUGGG	m7b	(m7b->m6c)	-0.190000	no TS	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.90898117C>A			COSN2333348		RK126_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3619-3p	ccttATGGTCCttctttag	2	GGGACCAU	m7b	Disrupted	-0.292000	-0.074000	No effect
hsa-miR-5585-5p	ccttatgGTACTTCtttag	0	UGAAGUAC	m7b	Created	no TS	-0.134000	-0.320000
hsa-miR-624-5p	ccttaTGGTACTtctttag	0	UAGUACCA	m7b	Created	no TS	-0.191000	-1.820000
hsa-miR-3619-3p	ccttATGGTCCttctttag	2	GGGACCAU	m7b	Disrupted	-0.292	-0.074	No effect
hsa-miR-5585-5p	ccttatgGTACTTCtttag	0	UGAAGUAC	m7b	Created	no TS	-0.134	-0.32
hsa-miR-624-5p	ccttaTGGTACTtctttag	0	UAGUACCA	m7b	Created	no TS	-0.191	-1.82

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
90895626	rs201191948	C	C	hsa-miR-3714 hsa-miR-548an	3 1	tggCTGCCTTtga tggcTGCCTTTga	Disrupted Disrupted	N N	-0.093 -0.047
90895626	rs201191948	C	A	hsa-miR-3157-5p hsa-miR-3973 hsa-miR-4691-3p hsa-miR-520g-3p hsa-miR-520h	4 1 4 1 1	TGGCTGActttga tggctgACTTTGA TGGCTGActttga tggctgACTTTGA tggctgACTTTGA	Created Created Created Created Created	N N N N N	-0.184 -0.019 -0.208 -0.007 -0.007
90895699	rs202035242	C
90895699	rs202035242	C	T	hsa-miR-150-5p hsa-miR-2116-3p hsa-miR-4713-5p hsa-miR-532-3p	1 1 1 1	gccagTTGGGAGA gccagtTGGGAGA gccagtTGGGAGA gccagtTGGGAGA	Created Created Created Created	N N N N	-0.21 -0.11 -0.159 -0.102
90895788	rs201367588	T	C	hsa-miR-1247-3p hsa-miR-3199 hsa-miR-4532 hsa-miR-8052	3 1 21 1	cagTCCCGGGAga CAGTCCCgggaga cagtCCCGGGAga CAGTCCCgggaga	Created Created Created Created	N N N N	-0.448 -0.14 -0.213 -0.14
90895788	rs201367588	T	T	hsa-miR-150-5p hsa-miR-1915-3p hsa-miR-2116-3p hsa-miR-3169 hsa-miR-4713-5p hsa-miR-4726-3p hsa-miR-532-3p hsa-miR-6764-5p hsa-miR-6840-3p	3 21 21 1 21 21 21 21 3	cagtccTGGGAGA cagtCCTGGGAga cagtccTGGGAGA CAGTCCTgggaga cagtccTGGGAGA cagtCCTGGGAga cagtccTGGGAGA cagtCCTGGGAga cagTCCTGGGAga	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	-0.113 -0.127 -0.124 -0.124 -0.165 -0.137 -0.123 -0.124 -0.338
90896066	rs14979	G
90896066	rs14979	G	A	hsa-miR-4662a-5p hsa-miR-562	3 2	TTGGCTActtcta ttgGCTACTTcta	Created Created	N N	-0.143 -0.078
90896459	rs199593787	G
90896459	rs199593787	G	A	hsa-miR-3619-3p hsa-miR-4716-5p hsa-miR-591	2 1 1	ctgaacATGGTCC ctgAACATGGtcc ctgaaCATGGTCc	Created Created Created	N N N	-0.074 0.073 -0.09
90896465	rs200233293	C	C	hsa-miR-3138 hsa-miR-3619-3p hsa-miR-3911 hsa-miR-4776-5p hsa-miR-4800-5p	2 1 1 1 1	gtgGTCCACAcct gTGGTCCAcacct gtggTCCACACct gTGGTCCAcacct gtGGTCCACAcct	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.065 -0.074 -0.034 -0.06 -0.301
90896465	rs200233293	C
90896559	rs201904421	T	T	hsa-miR-4760-5p hsa-miR-8061	4 4	gccATCTAAAgag gccATCTAAAgag	Disrupted Disrupted	N N	0.064 0.064
90896559	rs201904421	T	C	hsa-miR-1193 hsa-miR-432-3p hsa-miR-5004-3p hsa-miR-9-5p	4 4 4 6	gCCATCCAaagag gCCATCCAAagag gccATCCAAAgag gccatCCAAAGAg	Created Created Created Created	N N N N	-0.089 -0.19 0.022 0.023
90896572	rs158688	A	A	hsa-miR-3978 hsa-miR-6844 hsa-miR-9-5p	2 3 1	TTTCCAAagaaag tttcCAAAGAAag tttCCAAAGAaag	Disrupted Disrupted Disrupted	N N N	0.018 0.019 -0.025
90896572	rs158688	A	G	hsa-miR-1299 hsa-miR-3191-5p hsa-miR-326 hsa-miR-330-5p hsa-miR-4768-5p hsa-miR-518c-5p hsa-miR-6128 hsa-miR-6764-3p hsa-miR-6809-3p hsa-miR-6824-3p hsa-miR-6833-3p hsa-miR-875-3p	2 2 1 1 9 1 2 1 5 1 5 2	tTTCCAGAgaaag tttCCAGAGAAag tttCCAGAGAaag tttCCAGAGAaag tttccAGAGAAAg ttTCCAGAGAaag tTTCCAGAgaaag tttCCAGAGAaag tttccAGAGAAAg tttCCAGAGAaag tttccAGAGAAAg TTTCCAGAgaaag	Created Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N N	-0.061 -0.207 -0.064 -0.067 0.037 -0.184 0.002 -0.083 0.032 -0.069 0.03 -0.025
90896664	rs201475559	G
90896664	rs201475559	G	A	hsa-miR-146a-3p hsa-miR-301a-5p hsa-miR-3151-3p hsa-miR-3191-5p hsa-miR-3192-3p hsa-miR-3921 hsa-miR-4653-5p	0	aagaTCAGAGAat aagaTCAGAGAat aaGATCAGAgaat aagatCAGAGAAt aaGATCAGAgaat aagaTCAGAGAat aagaTCAGAGAat	Created Created Created Created Created Created Created	N N N N N N N	-0.033 -0.034 -0.043 -0.018 -0.109 -0.028 -0.028
90896919	rs199763889	-	C	hsa-miR-4740-3p	0	gctaCTCGGGAgg	Unknown	N	-0.045
90896919	rs199763889	-	T	hsa-miR-150-5p hsa-miR-562 hsa-miR-5697 hsa-miR-6814-5p	0	gctacTTGGGAGg GCTACTTgggagg gCTACTTGggagg gctaCTTGGGAgg	Unknown Unknown Unknown Unknown	N N N N	0.082 0.087 0.129 0.047
90897671	rs10217275	G	G	hsa-miR-1343-3p hsa-miR-3155a hsa-miR-3155b hsa-miR-484 hsa-miR-6742-3p hsa-miR-6783-3p hsa-miR-6852-5p hsa-miR-939-3p	2 1 1 1 2 2 2 2	tCCCAGGAgcctg tcccagGAGCCTG tcccagGAGCCTG tcccagGAGCCTG tCCCAGGAgcctg tCCCAGGAgcctg tCCCAGGAgcctg tCCCAGGAgcctg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N	-0.028 -0.043 -0.043 -0.006 -0.02 -0.028 -0.03 -0.018
90897671	rs10217275	G	C	hsa-miR-3692-5p hsa-miR-4731-5p hsa-miR-5589-5p hsa-miR-6762-3p	2 2 2 2	tcCCAGCAGcctg tCCCAGCAgcctg tCCCAGCAgcctg tcccAGCAGCCtg	Created Created Created Created	N N N N	-0.04 -0.026 -0.043 -0.034
90897694	rs200984283	A	A	hsa-miR-1299 hsa-miR-378j hsa-miR-4764-5p hsa-miR-4782-5p hsa-miR-516b-5p hsa-miR-5706 hsa-miR-6839-5p	3 2 2 2 3 2 2	acaTCCAGAAtgt acATCCAGAatgt ACATCCAgaatgt acATCCAGAAtgt acaTCCAGAAtgt acATCCAGAAtgt acATCCAGAatgt	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.009 -0.033 -0.016 -0.061 -0.01 -0.071 -0.033
90897694	rs200984283	A	G	hsa-miR-105-3p	2	ACATCCGgaatgt	Created	N	-0.2
90897923	rs73650275	A	A	hsa-miR-4684-5p hsa-miR-4768-5p hsa-miR-6782-3p hsa-miR-6809-3p hsa-miR-6833-3p	3 4 1 4 4	aTAGAGAAaggta atAGAGAAAggta atagagAAAGGTA atAGAGAAAggta atAGAGAAAggta	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.022 0.012 -0.03 0.007 0.012
90897923	rs73650275	A	G	hsa-miR-3667-3p hsa-miR-4724-3p hsa-miR-6780a-3p hsa-miR-6881-3p hsa-miR-7111-3p	3 1 4 4 4	atagAGGAAGGta atagagGAAGGTA atAGAGGAAggta atAGAGGAAggta atAGAGGAAggta	Created Created Created Created Created	N N N N N	-0.113 -0.129 -0.049 -0.059 -0.071
90897993	rs200073109	G	G	hsa-miR-1254 hsa-miR-3116 hsa-miR-4254	1 1 1	cTCCAGGCttcta cTCCAGGCttcta CTCCAGGcttcta	Disrupted Disrupted Disrupted	N N N	-0.104 -0.095 -0.102
90897993	rs200073109	G	C	hsa-miR-3135b hsa-miR-3154 hsa-miR-3652 hsa-miR-4430	1 1 1 1	CTCCAGCcttcta ctccagCCTTCTA cTCCAGCCttcta cTCCAGCCttcta	Created Created Created Created	N N N N	-0.091 -0.018 -0.081 -0.09
90898029	rs72729087	C	C	hsa-miR-503-3p hsa-miR-661 hsa-miR-6742-3p hsa-miR-6861-5p	1 2 2 1	ctcATACCCAggc ctcataCCCAGGC ctcatACCCAGGc ctcaTACCCAGgc	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.082 -0.19 -0.134 -0.112
90898029	rs72729087	C	T	hsa-miR-1254 hsa-miR-3116 hsa-miR-3201 hsa-miR-4791	2 2 1 1	ctcataTCCAGGC ctcataTCCAGGC ctCATATCCAggc ctCATATCCAggc	Created Created Created Created	N N N N	-0.197 -0.178 -0.188 -0.156
90898035	rs201467820	C	C	hsa-miR-486-3p hsa-miR-661	2 2	cccaggCTGCCCC CCCAGGCtgcccc	Disrupted Disrupted	N N	-0.173 -0.19
90898035	rs201467820	C	A	hsa-miR-1343-3p hsa-miR-4793-5p hsa-miR-6742-3p hsa-miR-6783-3p hsa-miR-6852-5p hsa-miR-939-3p	2 2 2 2 2 2	CCCAGGAtgcccc ccCAGGATGcccc CCCAGGAtgcccc CCCAGGAtgcccc CCCAGGAtgcccc CCCAGGAtgcccc	Created Created Created Created Created Created	N N N N N N	-0.145 -0.041 -0.155 -0.163 -0.117 -0.108
90898059	rs201342619	A	A	hsa-miR-100-3p hsa-miR-1225-5p hsa-miR-1229-5p hsa-miR-4453 hsa-miR-4538	2 1 1 1 1	taccCAAGCTTtt TACCCAAgctttt TACCCAAgctttt tacCCAAGCTttt tacCCAAGCTttt	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.042 -0.106 -0.161 -0.153 -0.125
90898059	rs201342619	A	G	hsa-miR-661 hsa-miR-6742-3p hsa-miR-6861-5p	1 1 1	taCCCAGGCtttt tACCCAGGctttt TACCCAGgctttt	Created Created Created	N N N	-0.212 -0.147 -0.089
90898115	rs199633431	G	G	hsa-miR-3619-3p hsa-miR-6816-3p	2 2	cttATGGTCCttc cttatGGTCCTTc	Disrupted Disrupted	N N	-0.218 -0.185
90898115	rs199633431	G
90898116	rs117866558	T	T	hsa-miR-3619-3p hsa-miR-6816-3p	2 2	ttATGGTCCttct ttatGGTCCTTct	Disrupted Disrupted	N N	-0.218 -0.185
90898116	rs117866558	T	G	hsa-miR-4493	1	ttatgGGCCTTCt	Created	N	-0.21
90898130	rs141926409	G
90898130	rs141926409	G	A	hsa-miR-4686	0	tAGCAGATAacaa	Created	N	-0.263

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser