SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001135052
Gene Symbol: SYK
Description: Homo sapiens spleen tyrosine kinase (SYK), transcript variant 2, mRNA.
Gene Location: chr9(+):93564011-93660842
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr9:g.90896066G>A COSN14793089 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4662a-5p aatTTGGCTActtctacgg
 0 UUAGCCAA m7b (m6b->m7b) no TS -0.143000 -0.200000
hsa-miR-548ao-5p aatttggcTACTTCTacgg
 0 AGAAGUAA m7a Created NA NA -1.950000
hsa-miR-548ax aatttggcTACTTCTacgg
 0 AGAAGUAA m7a Created NA NA -0.270000
hsa-miR-562 aatttgGCTACTTctacgg
 0 AAAGUAGC m7b Created no TS -0.078000 -0.080000


Mutation Mutation ID Sample Name Cancer Type
chr9:g.90896074G>A COSN14782726 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr9:g.90896572A>G COSN14753677 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1299 gagtTTCCAGAgaaagtat
 3
 UUCUGGAA m7b Created 0.043000 -0.018000 -0.390000
hsa-miR-3191-5p gagtttCCAGAGAaagtat
 0 CUCUCUGG m7b Created no TS -0.207000 -5.920000
hsa-miR-326 gagtttCCAGAGaaagtat
 0 CCUCUGGG m6b Created no TS -0.064000 -6.740000
hsa-miR-330-5p gagtttCCAGAGAaagtat
 0 UCUCUGGG m7a Created no TS -0.067000 -0.130000
hsa-miR-4768-5p gagtttccAGAGAAagtat
 4
 AUUCUCUC m6b Created 0.012000 0.049000 -4.910000
hsa-miR-518c-5p gagttTCCAGAGAaagtat
 2
 UCUCUGGA m8a Created -0.258000 -0.442000 -2.270000
hsa-miR-875-3p gagTTTCCAGagaaagtat
 0 CCUGGAAA m7b (m6b->m7b) 0.022000 -0.003000 -2.060000
hsa-miR-9-5p gagtttCCAAAGAaagtat
 3
 UCUUUGGU m7a Disrupted -0.001000 0.024000 1.810000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.90896785A>G ICGC_81192D66-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-106b-5p caGCACTTTAggaggccga
 1
 UAAAGUGC m8a (m8a->m7a) 0.057 0.077 0.06
hsa-miR-150-5p cagcactTTGGGAGgccga
 0 UCUCCCAA m7b Created no TS 0.042 -0.03
hsa-miR-17-5p caGCACTTTGggaggccga
 1
 CAAAGUGC m8a (m7a->m8a) 0.057 0.077 0.03
hsa-miR-186-3p cagcaCTTTGGGaggccga
 0 GCCCAAAG m7b Created -0.012 0.041 -0.75
hsa-miR-20a-5p caGCACTTTAggaggccga
 1
 UAAAGUGC m8a (m8a->m7a) 0.057 0.077 0.01
hsa-miR-20b-5p caGCACTTTGggaggccga
 1
 CAAAGUGC m8a (m7a->m8a) 0.057 0.077 0.01
hsa-miR-519d caGCACTTTGggaggccga
 1
 CAAAGUGC m8a (m7a->m8a) 0.046 0.067 0.01
hsa-miR-520g cagCACTTTGggaggccga
 0 ACAAAGUG m7b (m6b->m7b) no TS 0.139 -2.88
hsa-miR-520h cagCACTTTGggaggccga
 0 ACAAAGUG m7b (m6b->m7b) no TS 0.139 -2.9
hsa-miR-93-5p caGCACTTTGggaggccga
 1
 CAAAGUGC m8a (m7a->m8a) 0.057 0.077 0.01

Mutation Mutation ID Sample Name Cancer Type
chr9:g.90897086G>A COSN9527495 AOCS-128-1-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3692-5p atgCCAGCAGatataaata
 0 CCUGCUGG m7b (m7b->m6b) -0.184000 -0.086000 5.010000
hsa-miR-4686 atgccAGCAGATAtaaata
 4
 UAUCUGCU m8a Disrupted -0.001000 -0.012000 0.200000
hsa-miR-93-3p atgcCAGCAGatataaata
 1
 ACUGCUGA m6b Disrupted -0.018000 no TS 2.030000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.90897474A>T COSN2333347 RK032_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1255b-2-3p agtttggtaAAGTGGTgac
 2
 AACCACUU m7b (m7b->m6c) -0.042000 no TS 3.990000
hsa-miR-1255b-2-3p agtttggtaAAGTGGTgac
 0 AACCACUU m7b (m7b->m6c) -0.042 no TS 3.99

Mutation Mutation ID Sample Name Cancer Type
chr9:g.90898029C>T COSN14867368 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1254 attctcataTCCAGGCTgc
 0 AGCCUGGA m8a (m7b->m8a) -0.104000 -0.301000 -0.480000
hsa-miR-3116 attctcataTCCAGGCtgc
 0 UGCCUGGA m7b (m6c->m7b) -0.095000 -0.273000 No effect
hsa-miR-3201 attctCATATCCaggctgc
 0 GGGAUAUG m7b Created no TS -0.188000 -4.820000
hsa-miR-4791 attctCATATCCAggctgc
 0 UGGAUAUG m8a Created no TS -0.156000 -2.854000
hsa-miR-661 attctcataCCCAGGCtgc
 2
 UGCCUGGG m7b (m7b->m6c) -0.190000 no TS 0.020000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.90898117C>A COSN2333348 RK126_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3619-3p ccttATGGTCCttctttag
 2
 GGGACCAU m7b Disrupted -0.292000 -0.074000 No effect
hsa-miR-5585-5p ccttatgGTACTTCtttag
 0 UGAAGUAC m7b Created no TS -0.134000 -0.320000
hsa-miR-624-5p ccttaTGGTACTtctttag
 0 UAGUACCA m7b Created no TS -0.191000 -1.820000
hsa-miR-3619-3p ccttATGGTCCttctttag
 2
 GGGACCAU m7b Disrupted -0.292 -0.074 No effect
hsa-miR-5585-5p ccttatgGTACTTCtttag
 0 UGAAGUAC m7b Created no TS -0.134 -0.32
hsa-miR-624-5p ccttaTGGTACTtctttag
 0 UAGUACCA m7b Created no TS -0.191 -1.82

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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