| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_178509 |
|---|---|
| Gene Symbol: | STXBP4 |
| Description: | Homo sapiens syntaxin binding protein 4 (STXBP4), mRNA. |
| Gene Location: | chr17(+):53046125-53241449 |
| Browse Associations | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr17:g.55160309G>A | COSN14495617 | 8068988 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-126-5p |
catttattTAATAATtcac |
13 |
CAUUAUUA | m7b | Created | 0.422000 | 0.365000 | No effect | |
| hsa-miR-3671 |
cattTATTTGATaattcac |
0 | AUCAAAUA | m8a | Disrupted | 0.039000 | 0.146000 |
0.010000 |
|
| hsa-miR-4477a |
catttatTTAATAattcac |
0 | CUAUUAAG | m6b | Created | no TS | 0.023000 |
-0.080000 |
|
| hsa-miR-5692a |
catTTATTTGataattcac |
1 |
CAAAUAAU | m7a | (m7a->m6a) | 0.666000 | 0.732000 |
-0.010000 |
|
| hsa-miR-944 |
catttatttAATAATTcac |
7 |
AAAUUAUU | m7b | (m6c->m7b) | 0.052000 | 0.012000 |
-0.170000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr17:g.55161387C>T | COSN8839852 | AOCS-086-3-2 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-185-3p |
tgagagaAGCCCCagaggg |
2 |
AGGGGCUG | m6b | Disrupted | -0.013000 | no TS |
1.860000 |
|
| hsa-miR-204-3p |
tgagagaagTCCCAGaggg |
0 | GCUGGGAA | m6b | Created | -0.021000 | 0.003000 | No effect | |
| hsa-miR-3199 |
tgagagaAGTCCCagaggg |
4 |
AGGGACUG | m6b | Created | -0.102000 | -0.083000 | No effect | |
| hsa-miR-365a-5p |
tgagagAAGTCCCagaggg |
0 | AGGGACUU | m7b | Created | no TS | 0.036000 |
-0.030000 |
|
| hsa-miR-365b-5p |
tgagagAAGTCCCagaggg |
0 | AGGGACUU | m7b | Created | no TS | 0.036000 |
-0.020000 |
|
| hsa-miR-4298 |
tgagagaaGTCCCAGaggg |
3 |
CUGGGACA | m7a | Created | -0.092000 | -0.092000 | No effect | |
| hsa-miR-4314 |
tgagagaagTCCCAGAGgg |
1 |
CUCUGGGA | m8a | (m7b->m8a) | -0.027000 | 0.037000 |
-0.170000 |
|
| hsa-miR-4646-5p |
tgagagaagTCCCAGaggg |
0 | ACUGGGAA | m6b | Created | -0.000000 | 0.024000 | No effect | |
| hsa-miR-4667-5p |
tgagagaagCCCCAGaggg |
5 |
ACUGGGGA | m6b | Disrupted | -0.064000 | -0.064000 |
0.050000 |
|
| hsa-miR-637 |
tgagagaagCCCCAGaggg |
5 |
ACUGGGGG | m6b | Disrupted | -0.063000 | -0.060000 |
1.100000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr17:g.55162204G>A | COSN1723319 | RK050_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-593-5p |
catcaggtcGGTGCCataa |
1 |
AGGCACCA | m6b | Disrupted | -0.069000 | no TS |
2.780000 |
|
| hsa-miR-593-5p |
catcaggtcGGTGCCataa |
1 |
AGGCACCA | m6b | Disrupted | -0.069000 | no TS |
2.780000 |
|
| hsa-miR-593-5p |
catcaggtcGGTGCCataa |
0 | AGGCACCA | m6b | Disrupted | -0.069 | no TS |
2.78 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr17:g.55162496C>G | COSN5418181 | RK030_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-103a-2-5p |
acaatgtcAGAAGCactgt |
0 | AGCUUCUU | m6b | Created | no TS | 0.034000 | No effect | |
| hsa-miR-3182 |
acaatgtCAGAAGCactgt |
0 | GCUUCUGU | m7a | Created | NA | NA |
-0.010000 |
|
| hsa-miR-3660 |
acaaTGTCAGaagcactgt |
0 | ACUGACAG | m6b | Created | no TS | 0.039000 |
-4.130000 |
|
| hsa-miR-4256 |
acaatGTCAGAagcactgt |
0 | AUCUGACC | m6b | Created | no TS | 0.024000 |
-0.010000 |
|
| hsa-miR-4504 |
acaaTGTCACAagcactgt |
5 |
UGUGACAA | m7a | Disrupted | -0.013000 | -0.038000 |
0.030000 |
|
| hsa-miR-4526 |
acaaTGTCAGaagcactgt |
0 | GCUGACAG | m6b | Created | no TS | 0.033000 |
-0.010000 |
|
| hsa-miR-489 |
acaATGTCACaagcactgt |
1 |
GUGACAUC | m7a | (m7a->m6a) | -0.054000 | -0.054000 | No effect | |
| hsa-miR-542-3p |
acaaTGTCACAagcactgt |
5 |
UGUGACAG | m7a | Disrupted | -0.004000 | -0.040000 |
0.580000 |
|
| hsa-miR-636 |
acaatgtcaCAAGCACtgt |
2 |
UGUGCUUG | m7b | (m7b->m6c) | -0.215000 | -0.219000 | No effect | |
| hsa-miR-758 |
acaatGTCACAAgcactgt |
1 |
UUUGUGAC | m7b | Disrupted | 0.136000 | 0.103000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr17:g.55162533T>A | COSN7440039 | 8016470 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1179 |
gtagaacaAATGCTaatca |
0 | AAGCAUUC | m6b | Created | no TS | 0.062000 | No effect | |
| hsa-miR-3908 |
gtagaacaATTGCTaatca |
1 |
GAGCAAUG | m6b | Disrupted | 0.059000 | -0.004000 | No effect | |
| hsa-miR-3942-5p |
gtagaacaATTGCTaatca |
1 |
AAGCAAUA | m6b | Disrupted | -0.007000 | -0.063000 |
0.180000 |
|
| hsa-miR-4703-5p |
gtagaacaATTGCTAatca |
1 |
UAGCAAUA | m7a | Disrupted | -0.003000 | -0.063000 |
0.860000 |
|
| hsa-miR-4766-3p |
gtagaacaATTGCTAatca |
1 |
AUAGCAAU | m7b | Disrupted | -0.023000 | -0.078000 |
0.020000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr17:g.55163029G>C | 13_223 | SJMB032_D | Medulloblastoma | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-128 |
atgtctatACTGTGAatac |
4 |
UCACAGUG | m7a | Created | -0.083 | -0.111 | No effect | |
| hsa-miR-144-3p |
atgtctATACTGTgaatac |
0 | UACAGUAU | m7b | Created | 0.047 | 0.018 |
-2.4 |
|
| hsa-miR-27a-3p |
atgtctatACTGTGAAtac |
4 |
UUCACAGU | m8a | Created | -0.009 | -0.139 |
0.05 |
|
| hsa-miR-27b-3p |
atgtctatACTGTGAAtac |
4 |
UUCACAGU | m8a | Created | -0.009 | -0.139 |
0.07 |
|
| hsa-miR-3681-3p |
atgtctatACTGTGaatac |
0 | ACACAGUG | m6b | Created | -0.082 | -0.116 | No effect | |
| hsa-miR-625-3p |
atgtCTATAGTgtgaatac |
0 | GACUAUAG | m7b | Disrupted | -0.024 | no TS | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr17:g.55163481A>G | COSN1723320 | RK052_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-218-5p |
ccAAGCACAAtacaaatgc |
8 |
UUGUGCUU | m8a | (m8a->m7a) | -0.175000 | -0.066000 |
0.280000 |
|
| hsa-miR-4318 |
ccaagCACAGTacaaatgc |
0 | CACUGUGG | m6b | Created | no TS | -0.068000 |
-3.150000 |
|
| hsa-miR-4693-5p |
ccaagCACAGTAcaaatgc |
0 | AUACUGUG | m7b | Created | no TS | -0.088000 |
-0.270000 |
|
| hsa-miR-5008-3p |
ccaAGCACAGtacaaatgc |
0 | CCUGUGCU | m7b | (m6b->m7b) | no TS | -0.148000 |
-3.150000 |
|
| hsa-miR-892a |
ccaagCACAGTacaaatgc |
0 | CACUGUGU | m6b | Created | no TS | -0.070000 |
-0.030000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr17:g.55163496C>T | COSN1723321 | RK052_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-888-5p |
atgcatcTTTGAGTtcttt |
3 |
UACUCAAA | m7b | Created | 0.015000 | -0.019000 |
-0.080000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr17:g.55163910A>T | COSN6107202 | RK119_C01 | [liver][NS][carcinoma][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-23a-3p |
atagagtcATGTGATactt |
2 |
AUCACAUU | m7a | Created | -0.141000 | -0.141000 | No effect |
| hsa-miR-23b-3p |
atagagtcATGTGATactt |
2 |
AUCACAUU | m7a | Created | -0.141000 | -0.141000 | No effect |
| hsa-miR-23c |
atagagtcATGTGATactt |
2 |
AUCACAUU | m7a | Created | -0.141000 | -0.141000 | No effect |
| hsa-miR-34c-3p |
atagagtcaAGTGATactt |
0 | AAUCACUA | m6b | Disrupted | -0.098000 | no TS |
0.360000 |
| hsa-miR-3614-5p |
atagagtCAAGTGatactt |
0 | CCACUUGG | m6b | Disrupted | -0.106000 | no TS |
6.020000 |
| hsa-miR-4717-3p |
atagagtCATGTGatactt |
0 | ACACAUGG | m6b | Created | no TS | -0.114000 |
-0.010000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 55160122 | rs116051721 | G | |||||||
| T |
hsa-miR-126-5p hsa-miR-4477a hsa-miR-4795-3p |
10 9 10 |
cctTAATAATAat cCTTAATAAtaat ccttAATAATAAt |
Created Created Created |
N N N |
-0.154 -0.134 -0.114 |
|||
| 55161456 | rs145236956 | T | T |
hsa-miR-513b-5p |
6 |
ctataaTTGTGAA |
Disrupted |
N |
0.048 |
| C |
hsa-miR-128-3p hsa-miR-216a-3p hsa-miR-27a-3p hsa-miR-27b-3p hsa-miR-3681-3p hsa-miR-513a-5p |
5 5 5 5 5 6 |
ctataACTGTGAa ctataACTGTGAa ctataACTGTGAA ctataACTGTGAA ctataACTGTGAa ctataaCTGTGAA |
Created Created Created Created Created Created |
N N N N N N |
0.019 0.019 -0.03 -0.03 0.009 0.016 |
|||
| 55162210 | rs144641848 | A | A |
hsa-miR-183-5p hsa-miR-593-5p hsa-miR-8074 |
1 1 2 |
gGTGCCATAagag GGTGCCAtaagag ggtGCCATAAgag |
Disrupted Disrupted Disrupted |
N N N |
0.008 -0.069 0.005 |
| G |
hsa-miR-4445-3p hsa-miR-548al |
2 2 |
ggTGCCGTAagag ggTGCCGTAagag |
Created Created |
N N |
-0.075 -0.075 |
|||
| 55162505 | rs145387785 | T | T |
hsa-miR-128-3p hsa-miR-216a-3p hsa-miR-3681-3p hsa-miR-374b-3p hsa-miR-5682 hsa-miR-585-5p |
2 2 2 7 6 3 |
gCACTGTGctaaa gCACTGTGctaaa gCACTGTGctaaa gcactgTGCTAAA gcactGTGCTAAa gcacTGTGCTAAa |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
0.026 0.026 0.045 0.071 0.008 0.04 |
| G |
hsa-miR-1825 |
2 |
GCACTGGgctaaa |
Created |
N |
-0.024 |