SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_021199
Gene Symbol:	SQRDL
Description:	Homo sapiens sulfide quinone reductase-like (yeast) (SQRDL), nuclear gene encoding mitochondrial protein, mRNA.
Gene Location:	chr15(+):45927255-45983479
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.45691079C>T			COSN8744769		AOCS-141-3-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-134	ccaaaactgCAGTCACtga	0	UGUGACUG	m7b	(m7b->m6c)	-0.187000	no TS	0.560000
hsa-miR-139-5p	ccaaaACTGTAGtcactga	0	UCUACAGU	m7b	Created	no TS	-0.173000	-6.300000
hsa-miR-17-3p	ccaaaACTGCAGTcactga	4	ACUGCAGU	m8a	Disrupted	-0.208000	no TS	1.380000
hsa-miR-3118	ccaaaactgCAGTCACtga	0	UGUGACUG	m7b	(m7b->m6c)	-0.177000	no TS	0.860000
hsa-miR-4418	ccaaaaCTGCAGTcactga	4	CACUGCAG	m7b	Disrupted	-0.205000	no TS	1.360000
hsa-miR-509-3-5p	ccaaaaCTGCAGTcactga	4	UACUGCAG	m7b	Disrupted	-0.233000	no TS	1.360000
hsa-miR-509-5p	ccaaaaCTGCAGTcactga	4	UACUGCAG	m7b	Disrupted	-0.243000	no TS	1.340000
hsa-miR-582-5p	ccaaAACTGTAgtcactga	0	UUACAGUU	m7b	Created	no TS	-0.124000	-2.000000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.45691091G>T			COSN7045845		8031681		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4760-3p	tcacTGAATTaccaagagc	0	AAAUUCAU	m6b	Created	no TS	0.016000	-0.230000
hsa-miR-5587-5p	tcactgaaTGACCAagagc	5	AUGGUCAC	m6b	Disrupted	-0.492000	-0.361000	0.950000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
45691156	rs182974483	A	A	hsa-miR-133a-3p hsa-miR-133b hsa-miR-5002-5p hsa-miR-5587-5p	11 11 21 9	atggtGACCAAAt atggtGACCAAAt atggtgACCAAAT atgGTGACCAAat	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.115 -0.115 -0.02 -0.361
			G	hsa-miR-3187-3p hsa-miR-4435 hsa-miR-4701-5p hsa-miR-548s hsa-miR-588	10 10 9 10 9	atggTGGCCAAat atggTGGCCAAat atgGTGGCCAAat atggTGGCCAAat atgGTGGCCAAat	Created Created Created Created Created	N N N N N	-0.149 -0.152 -0.446 -0.154 -0.415

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