SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_018225
Gene Symbol:	SMU1
Description:	Homo sapiens smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) (SMU1), mRNA.
Gene Location:	chr9(-):33041849-33076714
Browse Associations

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33041862T>G			COSN7808011		PCSI_0083_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1197	atacaatacGTGTCCTttt	2	UAGGACAC	m7b	(m6b->m7b)	0.004000	-0.294000	-0.440000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33042019G>A			COSN6389586		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-323b-5p	cgatgttacACAACCacta	0	AGGUUGUC	m6b	Created	no TS	-0.166000	-2.350000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33042298T>C			COSN5122029		HCC145		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4318	ctgcttaCACAGTaatgaa	0	CACUGUGG	m6b	Created	no TS	-0.094000	-0.020000
hsa-miR-4495	ctgcTTACATagtaatgaa	2	AAUGUAAA	m6b	Disrupted	0.020000	no TS	0.730000
hsa-miR-4693-5p	ctgcttaCACAGTAatgaa	0	AUACUGUG	m7b	Created	no TS	-0.269000	-0.020000
hsa-miR-892a	ctgcttACACAGTaatgaa	0	CACUGUGU	m7b	Created	no TS	-0.266000	No effect
hsa-miR-4318	ctgcttaCACAGTaatgaa	0	CACUGUGG	m6b	Created	no TS	-0.094000	-0.020000
hsa-miR-4495	ctgcTTACATagtaatgaa	2	AAUGUAAA	m6b	Disrupted	0.020000	no TS	0.730000
hsa-miR-4693-5p	ctgcttaCACAGTAatgaa	0	AUACUGUG	m7b	Created	no TS	-0.269000	-0.020000
hsa-miR-892a	ctgcttACACAGTaatgaa	0	CACUGUGU	m7b	Created	no TS	-0.266000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33043129C>T			COSN14737058		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33043201G>C			COSN7566915		8034252		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2117	ttaAGAGAACAaattgcta	0	UGUUCUCU	m8a	Created	0.041000	-0.044000	-0.370000
hsa-miR-4273	ttaaGAGAACAaattgcta	2	GUGUUCUC	m7b	Created	0.064000	0.003000	-2.690000
hsa-miR-4659a-3p	ttaagAGAAGAAAttgcta	2	UUUCUUCU	m8a	Disrupted	0.226000	0.129000	0.530000
hsa-miR-4659b-3p	ttaagAGAAGAAAttgcta	2	UUUCUUCU	m8a	Disrupted	0.226000	0.129000	0.240000
hsa-miR-4677-5p	ttaagAGAACAAattgcta	2	UUGUUCUU	m7a	Created	0.061000	0.088000	-0.010000
hsa-miR-942	ttaAGAGAAGAaattgcta	0	UCUUCUCU	m8a	Disrupted	-0.058000	-0.015000	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33043715C>T			COSN7566916		8035567		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-31-5p	ctcTCTTGCCTcactctca	1	AGGCAAGA	m8a	Disrupted	-0.068000	-0.087000	0.010000
hsa-miR-4316	ctctcttGCCTCACtctca	2	GGUGAGGC	m7b	Disrupted	-0.072000	no TS	0.510000
hsa-miR-451b	ctcTCTTGCTtcactctca	4	UAGCAAGA	m7b	(m6c->m7b)	0.086000	0.137000	-0.280000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33044313A>G			COSN5244059		SS6003312		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-194-5p	caCTGTTACAaaattggcg	0	UGUAACAG	m8a	(m8a->m7b)	0.078000	0.073000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33044518C>G			COSN14734647		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-518e-3p	ctccagcGCGCTTacagcc	0	AAAGCGCU	m6b	Created	no TS	-0.021000	-0.320000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33045612C>T			ICGC_C524EF7C-2A78-11E2-BDED-1EFD496BB9B8		CPCG_0103_Pr_P_P4		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3714	ccgcCTGCCTTggcctccc	0	GAAGGCAG	m7b	Created	0.081	0.231	No effect
hsa-miR-4436b-3p	ccgcCTGCCCTGgcctccc	0	CAGGGCAG	m8a	Disrupted	-0.007	-0.112	No effect
hsa-miR-4685-5p	ccgcctGCCCTGGcctccc	0	CCCAGGGC	m7b	Disrupted	-0.074	-0.08	0.01
hsa-miR-940	ccgCCTGCCTTggcctccc	0	AAGGCAGG	m8a	Created	-0.047	0.043	-0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33046261C>A			COSN6389587		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-146a-3p	acaagaaTTCAGAGttttg	1	CCUCUGAA	m7b	Disrupted	-0.062000	no TS	3.650000
hsa-miR-4452	acaaGAATTCAgagttttg	2	UUGAAUUC	m7b	Disrupted	0.111000	0.092000	No effect
hsa-miR-4680-3p	acaagAATTCAGAgttttg	3	UCUGAAUU	m8a	Disrupted	0.199000	0.123000	No effect
hsa-miR-4714-5p	acaagaatTCAGAGTTttg	2	AACUCUGA	m8a	Disrupted	-0.111000	no TS	0.010000
hsa-miR-5187-3p	acaagaATTCAGagttttg	1	ACUGAAUC	m6b	Disrupted	0.045000	no TS	0.120000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33046801T>C			ICGC_80BD30C4-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1827	gcgattctcCTGCCTCAgc	0	UGAGGCAG	m8a	(m7a->m8a)	-0.714	-0.87	No effect
hsa-miR-31-5p	gcgattcTCTTGCCTcagc	0	AGGCAAGA	m8a	Disrupted	-0.068	0.019	No effect
hsa-miR-3123	gcgATTCTCTtgcctcagc	0	CAGAGAAU	m7b	(m7b->m6c)	0.054	no TS	0.01
hsa-miR-4722-5p	gcgattCTCCTGCCtcagc	0	GGCAGGAG	m8a	Created	-0.02	-0.154	No effect
hsa-miR-4768-3p	gcgatTCTCCTGcctcagc	0	CCAGGAGA	m7b	Created	0.068	0.002	No effect
hsa-miR-940	gcgattctCCTGCCTcagc	0	AAGGCAGG	m7b	Created	-0.047	-0.194	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.33047214T>G			COSN168505		GC1_T		[stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3128	tttttttttTTGCCAGctt	0	UCUGGCAA	m7b	(m7b->m6b)	-0.357000	no TS	0.040000
hsa-miR-3613-3p	tttTTTTTTGTgccagctt	2	ACAAAAAA	m8a	Created	0.125000	0.104000	No effect
hsa-miR-3128	tttttttttTTGCCAGctt	0	UCUGGCAA	m7b	(m7b->m6b)	-0.357	no TS	0.04
hsa-miR-3613-3p	tttTTTTTTGTgccagctt	0	ACAAAAAA	m8a	Created	0.125	0.104	No effect

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
33043356	rs13283015	T	T	hsa-miR-2277-3p hsa-miR-3120-3p hsa-miR-3660 hsa-miR-451b hsa-miR-4526 hsa-miR-888-3p	2 3 6 3 6 4	tcttGCTGTCAgt tcTTGCTGTcagt tcttgCTGTCAGt TCTTGCTgtcagt tcttgCTGTCAGt tcttgcTGTCAGT	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.024 0.037 -0.006 -0.018 0.022 0.036
33043356	rs13283015	T	C	hsa-miR-31-5p hsa-miR-4445-3p hsa-miR-548al	3 3 3	TCTTGCCgtcagt tcTTGCCGTcagt tcTTGCCGTcagt	Created Created Created	N N N	-0.059 -0.127 -0.089
33043720	rs10971362	C	C	hsa-miR-31-5p	2	ttctcTCTTGCCt	Disrupted	N	0.019
33043720	rs10971362	C	T	hsa-miR-4311 hsa-miR-548aj-5p hsa-miR-548f-5p hsa-miR-548g-5p hsa-miR-548x-5p	1 2 2 2 2	tTCTCTTTtgcct ttctCTTTTGCct ttctCTTTTGCct ttctCTTTTGCct ttctCTTTTGCct	Created Created Created Created Created	N N N N N	0.113 0.087 0.087 0.087 0.087
33043933	rs188619940	T
33043933	rs188619940	T	G	hsa-miR-3613-3p hsa-miR-628-5p	1 1	TTTTTTGtcagca ttttttGTCAGCA	Created Created	N N	0.248 -0.105
33044518	rs3814517	C
33044518	rs3814517	C	G	hsa-miR-518e-3p	0	cagcGCGCTTAca	Created	N	-0.021
33044683	rs185396222	T
33044683	rs185396222	T	C	hsa-miR-451b hsa-miR-4766-3p	2 2	ccCTTGCTAatct cccTTGCTAAtct	Created Created	N N	0.033 0.062
33045420	rs191823332	T	T	hsa-miR-4470	5	ttcccaTTTGCCA	Disrupted	N	0.051
33045420	rs191823332	T	C	hsa-miR-31-5p hsa-miR-6809-5p	5 5	ttcccaCTTGCCA ttcccaCTTGCCA	Created Created	N N	0.017 0.014
33046826	rs141054260	C	C	hsa-miR-25-5p hsa-miR-6087 hsa-miR-658	2 2 2	aacCTCCGCCtcc aacctCCGCCTCc aaCCTCCGCctcc	Disrupted Disrupted Disrupted	N N N	-0.207 -0.2 -0.244
33046826	rs141054260	C	T	hsa-miR-1827 hsa-miR-1910-3p hsa-miR-2467-3p hsa-miR-3612 hsa-miR-4257 hsa-miR-650 hsa-miR-6511a-5p	2 2 2 2 2 2 2	aacctCTGCCTCc aaccTCTGCCTcc aaCCTCTGCctcc aacctcTGCCTCC aACCTCTGcctcc aacctcTGCCTCC aaccTCTGCCTcc	Created Created Created Created Created Created Created	N N N N N N N	-0.126 -0.046 -0.137 -0.118 -0.09 -0.118 -0.046
33046892	rs190311141	G	G	hsa-miR-3613-3p hsa-miR-371a-5p hsa-miR-371b-5p hsa-miR-372-5p hsa-miR-373-5p hsa-miR-616-5p	2 2 2 2 2 2	TTTTTTGAgatgg tttTTTGAGAtgg ttTTTTGAGAtgg tttTTTGAGAtgg ttTTTTGAGAtgg ttTTTTGAGAtgg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	0.008 -0.014 -0.098 -0.018 -0.098 -0.119
33046892	rs190311141	G	A	hsa-miR-302a-5p	2	tttTTTAAGAtgg	Created	N	0.029
33047211	rs142403776	-	-	hsa-miR-3128 hsa-miR-320e hsa-miR-4470	4 4 2	tttTTGCCAGctt tttttgCCAGCTT ttTTTGCCAgctt	Unknown Unknown Unknown	N N N	-0.357 -0.027 -0.149
33047211	rs142403776	-	G	hsa-miR-3190-5p hsa-miR-3926 hsa-miR-548s	4 2 4	ttttTGGCCAGctt ttTTTGGCCAgctt tttTTGGCCAgctt	Unknown Unknown Unknown	N N N	-0.3 -0.424 -0.259
33047212	rs141860541	-	-	hsa-miR-3128 hsa-miR-3613-3p hsa-miR-4470	2 1 2	ttttttTTGCCAGcttt ttTTTTTTGccagcttt tttttTTTGCCAgcttt	Unknown Unknown Unknown	N N N	0.003 -0.013 -0.004
33047212	rs141860541	-	TTT
33047212	rs199501271	G	G	hsa-miR-3128 hsa-miR-3613-3p hsa-miR-4470	4 1 2	ttttTTGCCAGct TTTTTTGccagct tttTTTGCCAgct	Disrupted Disrupted Disrupted	N N N	-0.357 -0.05 -0.149
33047212	rs199501271	G	T	hsa-miR-3148 hsa-miR-6124 hsa-miR-875-3p	1 2 4	ttTTTTTCCAgct tttTTTTCCAgct ttttTTTCCAGct	Created Created Created	N N N	-0.191 -0.052 -0.192
33047212	rs35635616	G	G	hsa-miR-3128 hsa-miR-3613-3p hsa-miR-4470	4 1 2	ttttTTGCCAGct TTTTTTGccagct tttTTTGCCAgct	Disrupted Disrupted Disrupted	N N N	-0.357 -0.05 -0.149
33047212	rs35635616	G	T	hsa-miR-3148 hsa-miR-6124 hsa-miR-875-3p	1 2 4	ttTTTTTCCAgct tttTTTTCCAgct ttttTTTCCAGct	Created Created Created	N N N	-0.191 -0.052 -0.192
33047213	rs138553649	-	-	hsa-miR-3128 hsa-miR-3613-3p hsa-miR-4470	2 1 2	ttttttTTGCCAGct ttTTTTTTGccagct tttttTTTGCCAgct	Unknown Unknown Unknown	N N N	0.002 -0.013 -0.006
33047213	rs138553649	-	TT
33047213	rs2274768	T	T	hsa-miR-3128 hsa-miR-3613-3p hsa-miR-4470	4 1 2	tttttTTGCCAGc tTTTTTTGccagc ttttTTTGCCAgc	Disrupted Disrupted Disrupted	N N N	-0.357 -0.005 -0.149
33047213	rs2274768	T	G	hsa-miR-3190-5p hsa-miR-3926 hsa-miR-548s	4 1 2	tttttTGGCCAGc tttTTTGGCCAgc ttttTTGGCCAgc	Created Created Created	N N N	-0.308 -0.434 -0.257

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser