SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_004170
Gene Symbol: SLC1A1
Description: Homo sapiens solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (SLC1A1), mRNA.
Gene Location: chr9(+):4490426-4587469
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr9:g.4585649G>A COSN1378946 HCC107T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3187-3p acactaATGGCCAAgtgta
 0 UUGGCCAU m8a Disrupted -0.438000 no TS 10.560000
hsa-miR-4435 acactaaTGGCCAagtgta
 3
 AUGGCCAG m6b Disrupted -0.165000 no TS 9.410000
hsa-miR-4529-5p acactaATGGCCaagtgta
 0 AGGCCAUC m6b Disrupted -0.205000 no TS 9.840000
hsa-miR-548s acactaaTGGCCAagtgta
 3
 AUGGCCAA m6b Disrupted -0.171000 no TS 6.160000
hsa-miR-5587-5p acactaaTGACCAagtgta
 0 AUGGUCAC m6b Created no TS -0.153000 -4.360000
hsa-miR-3187-3p acactaATGGCCAAgtgta
 0 UUGGCCAU m8a Disrupted -0.438000 no TS 10.560000
hsa-miR-4435 acactaaTGGCCAagtgta
 3
 AUGGCCAG m6b Disrupted -0.165000 no TS 9.410000
hsa-miR-4529-5p acactaATGGCCaagtgta
 0 AGGCCAUC m6b Disrupted -0.205000 no TS 9.840000
hsa-miR-548s acactaaTGGCCAagtgta
 3
 AUGGCCAA m6b Disrupted -0.171000 no TS 6.160000
hsa-miR-5587-5p acactaaTGACCAagtgta
 0 AUGGUCAC m6b Created no TS -0.153000 -4.360000
hsa-miR-3187-3p acactaATGGCCAAgtgta
 0 UUGGCCAU m8a Disrupted -0.438 no TS 10.56
hsa-miR-4435 acactaaTGGCCAagtgta
 3
 AUGGCCAG m6b Disrupted -0.165 no TS 9.41
hsa-miR-4529-5p acactaATGGCCaagtgta
 0 AGGCCAUC m6b Disrupted -0.205 no TS 9.84
hsa-miR-548s acactaaTGGCCAagtgta
 3
 AUGGCCAA m6b Disrupted -0.171 no TS 6.16
hsa-miR-5587-5p acactaaTGACCAagtgta
 0 AUGGUCAC m6b Created no TS -0.153 -4.36

Mutation Mutation ID Sample Name Cancer Type
chr9:g.4586149G>T COSN15467127 AOCS-139-1-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1248 agggAGAAGGattcttttt
 2
 ACCUUCUU m6b Disrupted -0.054000 no TS 1.720000
hsa-miR-3682-5p agggAGAAGTAttcttttt
 0 CUACUUCU m7b Created no TS -0.043000 -0.210000
hsa-miR-500a-5p agggagAAGGATTcttttt
 2
 UAAUCCUU m7b Disrupted -0.055000 no TS No effect
hsa-miR-1248 agggAGAAGGattcttttt
 2
 ACCUUCUU m6b Disrupted -0.054000 no TS 1.720000
hsa-miR-3682-5p agggAGAAGTAttcttttt
 0 CUACUUCU m7b Created no TS -0.043000 -0.210000
hsa-miR-500a-5p agggagAAGGATTcttttt
 2
 UAAUCCUU m7b Disrupted -0.055000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr9:g.4586290G>A COSN399091 LFS_MB2 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][large_cell]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1279 accgtCAATATGAaataaa
 0 UCAUAUUG m8a Created no TS -0.102000 -0.030000
hsa-miR-130a-5p accgtcAATGTGAAataaa
 5
 UUCACAUU m8a Disrupted -0.289000 -0.236000 5.790000
hsa-miR-23a-3p accgtcAATGTGAaataaa
 5
 AUCACAUU m7b Disrupted -0.310000 -0.257000 5.130000
hsa-miR-23b-3p accgtcAATGTGAaataaa
 5
 AUCACAUU m7b Disrupted -0.310000 -0.257000 1.770000
hsa-miR-23c accgtcAATGTGAaataaa
 5
 AUCACAUU m7b Disrupted -0.310000 -0.257000 0.450000
hsa-miR-5007-3p accgtcaATATGAaataaa
 2
 AUCAUAUG m6b Created -0.038000 -0.016000 -0.060000
hsa-miR-1279 accgtCAATATGAaataaa
 0 UCAUAUUG m8a Created no TS -0.102 -0.03
hsa-miR-130a-5p accgtcAATGTGAAataaa
 14
 UUCACAUU m8a Disrupted -0.289 -0.236 5.79
hsa-miR-23a-3p accgtcAATGTGAaataaa
 14
 AUCACAUU m7b Disrupted -0.31 -0.257 5.13
hsa-miR-23b-3p accgtcAATGTGAaataaa
 14
 AUCACAUU m7b Disrupted -0.31 -0.257 1.77
hsa-miR-23c accgtcAATGTGAaataaa
 14
 AUCACAUU m7b Disrupted -0.31 -0.257 0.45
hsa-miR-5007-3p accgtcaATATGAaataaa
 0 AUCAUAUG m6b Created -0.038 -0.016 -0.06


Mutation Mutation ID Sample Name Cancer Type
chr9:g.4586403G>A COSN6391303 RK176_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr9:g.4586915C>A COSN7568921 8067180 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-298 cttgtcaTTCTGCTaattt
 11
 AGCAGAAG m7a Disrupted -0.154000 -0.154000 1.480000
hsa-miR-374b-3p cttgtcattCTGCTAAttt
 8
 CUUAGCAG m7b (m7b->m6c) -0.169000 no TS 2.270000
hsa-miR-4524a-5p cttgtcattCTGCTAattt
 8
 AUAGCAGC m6b Disrupted -0.123000 no TS 1.440000
hsa-miR-4524b-5p cttgtcattCTGCTAattt
 8
 AUAGCAGC m6b Disrupted -0.126000 no TS 1.010000


Mutation Mutation ID Sample Name Cancer Type
chr9:g.4586988C>T COSN7808810 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr9:g.4587366A>G COSN9712865 AOCS-128-1-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3662 ccagttaTCATTTTggagt
 0 GAAAAUGA m7b Disrupted 0.001000 no TS 0.360000
hsa-miR-4698 ccagttatCATTTTGgagt
 0 UCAAAAUG m7b Disrupted -0.061000 no TS 0.010000
hsa-miR-548ad ccagttaTCGTTTTggagt
 0 GAAAACGA m7b Created no TS -0.147000 -3.710000
hsa-miR-548o-3p ccagttatcGTTTTGGagt
 0 CCAAAACU m7a (m6b->m7a) NA NA -0.070000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
4586103 rs181277121 A A hsa-miR-1273h-3p
hsa-miR-137
hsa-miR-25-3p
hsa-miR-298
hsa-miR-32-5p
hsa-miR-363-3p
hsa-miR-367-3p
hsa-miR-3678-3p
hsa-miR-92a-3p
hsa-miR-92b-3p
12
10
12
11
12
12
12
12
12
12
 tTCTGCAAtaaca
ttctGCAATAAca
ttcTGCAATAaca
TTCTGCAataaca
ttcTGCAATAaca
ttcTGCAATAaca
ttcTGCAATAaca
tTCTGCAAtaaca
ttcTGCAATAaca
ttcTGCAATAaca
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
N
 -0.099
-0.031
-0.064
-0.086
-0.067
-0.057
-0.057
-0.086
-0.054
-0.054
G hsa-miR-6767-5p
12
 tTCTGCGAtaaca
 Created
N
 -0.197
4586660 rs145632403 T
C hsa-miR-298
2
 CTTCTGCtatcag
 Created
N
 -0.095
4586919 rs1051825 T T hsa-miR-374b-3p
hsa-miR-4524a-5p
hsa-miR-4524b-5p
8
8
8
 ttCTGCTAAttta
ttCTGCTAAttta
ttCTGCTAAttta
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.169
-0.123
-0.126
C hsa-miR-7150
8
 ttCTGCCAAttta
 Created
N
 -0.14
4587063 rs1051831 G G hsa-miR-302a-5p
11
 tttcatGTTTAAG
 Disrupted
N
 -0.158
T hsa-miR-3646
hsa-miR-3662
hsa-miR-548c-3p
2
2
2
 tTTCATTTttaag
ttTCATTTTtaag
tttcATTTTTAag
 Created
Created
Created
N
N
N
 -0.029
-0.031
0.109

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