SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001046
Gene Symbol: SLC12A2
Description: Homo sapiens solute carrier family 12 (sodium/potassium/chloride transporters), member 2 (SLC12A2), transcript variant 1, mRNA.
Gene Location: chr5(+):127419482-127525380
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr5:g.128186909C>T COSN6861927 RK119_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-329 caataaaaGTGTGTTaact
 4
 AACACACC m7a Created -0.005000 -0.005000 -9.110000
hsa-miR-362-3p caataaaaGTGTGTTaact
 4
 AACACACC m7a Created -0.012000 -0.012000 -6.670000
hsa-miR-603 caataaaAGTGTGTtaact
 4
 CACACACU m7b Created -0.001000 -0.251000 -7.150000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.128187245A>G COSN2068217 RK194_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3680-5p aaggtttatGTGAGTatat
 0 GACUCACU m6b Created no TS -0.118000 No effect
hsa-miR-4798-3p aaggtttatGTGAGTatat
 0 AACUCACG m6b Created no TS -0.164000 -0.090000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.128187798A>G COSN2068218 RK180_C02 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548au-3p aaAACTGCCAgtttgtgct
 17
 UGGCAGUU m8a (m8a->m7a) -0.195000 -0.115000 0.150000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.128188044G>T COSN1306771 HX17T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-300 tatgttgCTTGTATtttgc
 0 UAUACAAG m7b Created no TS 0.044000 No effect
hsa-miR-381 tatgttgCTTGTATtttgc
 0 UAUACAAG m7b Created no TS 0.035000 -0.040000
hsa-miR-634 tatgtTGCTGGTattttgc
 2
 AACCAGCA m7b Disrupted -0.186000 no TS 0.030000
hsa-miR-300 tatgttgCTTGTATtttgc
 0 UAUACAAG m7b Created no TS 0.044 No effect
hsa-miR-381 tatgttgCTTGTATtttgc
 0 UAUACAAG m7b Created no TS 0.035 -0.04
hsa-miR-634 tatgtTGCTGGTattttgc
 2
 AACCAGCA m7b Disrupted -0.186 no TS 0.03

Mutation Mutation ID Sample Name Cancer Type
chr5:g.128188540G>A COSN9404253 AOCS-163-1-4 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3197 gatccaccCGCCTCagcct
 1
 GGAGGCGC m6b Disrupted -0.085000 no TS 1.120000
hsa-miR-363-5p gaTCCACCCGcctcagcct
 1
 CGGGUGGA m8a (m8a->m7a) -0.045000 -0.140000 -0.290000
hsa-miR-3656 gatcCACCCGCCtcagcct
 1
 GGCGGGUG m8a Disrupted -0.125000 no TS 8.780000
hsa-miR-4649-3p gatccacccGCCTCAGcct
 1
 UCUGAGGC m7b (m7b->m6c) 0.058000 0.012000 0.070000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.128188554G>A ICGC_7914936C-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-204-3p agccTCCCAGagtgctggg
 2
 GCUGGGAA m6b Disrupted 0.014 no TS No effect
hsa-miR-30b-3p agCCTCCCAGagtgctggg
 0 CUGGGAGG m8a (m8a->m7a) 0.022 -0.055 No effect
hsa-miR-30c-1-3p agcCTCCCAGagtgctggg
 0 CUGGGAGA m7a (m7a->m6a) no TS 0.01 No effect
hsa-miR-30c-2-3p agcCTCCCAGagtgctggg
 0 CUGGGAGA m7a (m7a->m6a) no TS 0.004 No effect
hsa-miR-3122 agccTCCCAAagtgctggg
 0 GUUGGGAC m6b Created no TS 0.04 -0.49
hsa-miR-3192 agcCTCCCAGAgtgctggg
 2
 UCUGGGAG m8a Disrupted -0.026 no TS 0.57
hsa-miR-326 agcctCCCAGAGtgctggg
 2
 CCUCUGGG m7b Disrupted 0 no TS 0.01
hsa-miR-330-5p agcctCCCAGAGtgctggg
 2
 UCUCUGGG m7b Disrupted -0.009 no TS 0.08
hsa-miR-3689a-3p agCCTCCCAGagtgctggg
 0 CUGGGAGG m8a (m8a->m7a) 0.013 -0.065 No effect
hsa-miR-3689b-3p agCCTCCCAGagtgctggg
 0 CUGGGAGG m8a (m8a->m7a) 0.013 -0.065 No effect
hsa-miR-3689c agCCTCCCAGagtgctggg
 0 CUGGGAGG m8a (m8a->m7a) 0.013 -0.065 No effect
hsa-miR-4314 agccTCCCAGAGtgctggg
 2
 CUCUGGGA m8a Disrupted 0.052 no TS 0.01
hsa-miR-4646-5p agccTCCCAGagtgctggg
 2
 ACUGGGAA m6b Disrupted 0.011 no TS No effect
hsa-miR-514a-5p agcctcCCAGAGTgctggg
 2
 UACUCUGG m7b Disrupted 0.028 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.128188574C>T ICGC_DAAD83D6-2A78-11E2-B303-24FD496BB9B8 CPCG_0103_Pr_P_P6 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1228-3p ttacAGGTGTGAgccactg
 0 UCACACCU m8a Created no TS -0.041 -0.77
hsa-miR-342-3p ttacagGTGTGAGccactg
 0 UCUCACAC m7b Created -0.107 -0.094 No effect
hsa-miR-4284 ttacaggtGTGAGCCactg
 0 GGGCUCAC m7b Created no TS -0.119 -0.02

Mutation Mutation ID Sample Name Cancer Type
chr5:g.128188584C>T COSN5588361 RK120_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-128 gagcCACTGTGcctggctg
 0 UCACAGUG m7b Created no TS 0.085000 No effect
hsa-miR-3681-3p gagcCACTGTGcctggctg
 0 ACACAGUG m7b Created no TS 0.076000 -0.010000
hsa-miR-4269 gagccactGTGCCTGgctg
 0 GCAGGCAC m7b Created no TS -0.048000 -1.480000
hsa-miR-4645-5p gagccactgTGCCTGGctg
 0 ACCAGGCA m7b (m6c->m7b) no TS -0.016000 -0.080000
hsa-miR-4673 gagccactgTGCCTGGctg
 0 UCCAGGCA m7b (m6c->m7b) no TS -0.034000 -0.040000
hsa-miR-5582-5p gagccacTGTGCCTggctg
 0 UAGGCACA m7b Created -0.172000 -0.118000 No effect
hsa-miR-5693 gaGCCACTGCgcctggctg
 2
 GCAGUGGC m8a (m8a->m7a) 0.002000 -0.025000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.128188620A>T COSN15073057 LP6005690-DNA_A02 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4662b tagaCATCTTTaacgttat
 0 AAAGAUGG m7a Created NA NA -0.750000


Mutation Mutation ID Sample Name Cancer Type
chr5:g.128189039A>G COSN14456070 8066037 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr5:g.128189519G>C COSN6861928 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-136-3p agctctggtCGATGATtat
 0 CAUCAUCG m7b (m6c->m7b) -0.103000 -0.327000 -2.770000
hsa-miR-4733-3p agctCTGGTGGatgattat
 0 CCACCAGG m7a Disrupted NA NA 0.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
128186672 rs199594807 G G hsa-miR-3622a-5p
hsa-miR-4423-3p
hsa-miR-5582-5p
14
14
14
 acttcaGTGCCTA
acttcaGTGCCTA
acttcaGTGCCTA
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.197
-0.274
-0.172
128187981 rs187398964 G G hsa-miR-329-3p
hsa-miR-362-3p
hsa-miR-3941
hsa-miR-4789-5p
hsa-miR-603
4
4
4
3
4
 gtGTGTGTAtata
gtGTGTGTAtata
gtGTGTGTAtata
gtgtGTGTATAta
gtGTGTGTAtata
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 0.004
0.004
-0.002
0.025
0.001
A hsa-miR-190a-3p
hsa-miR-5011-5p
1
1
 gtgtgtATATATA
gtgtgTATATATA
 Created
Created
N
N
 0.073
0.166

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