SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_005068
Gene Symbol:	SIM1
Description:	Homo sapiens single-minded homolog 1 (Drosophila) (SIM1), mRNA.
Gene Location:	chr6(-):100836749-100911551
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.100389370T>A			13_152		SJMB020_D		Medulloblastoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-141-3p	cagCAGTGTTAagtgtttg	0	UAACACUG	m8a	Disrupted	-0.155	no TS	7.97
hsa-miR-200a-3p	cagCAGTGTTAagtgtttg	0	UAACACUG	m8a	Disrupted	-0.155	no TS	7.71

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.100389394T>C			COSN6717463		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-181b-3p	gaaaacCAGTGAagtgcca	7	CUCACUGA	m6b	Disrupted	-0.061000	no TS	No effect
hsa-miR-29b-1-5p	gaAAACCAGCgaagtgcca	7	GCUGGUUU	m8a	(m7b->m8a)	-0.233000	-0.206000	0.010000
hsa-miR-4420	gaaaacCAGTGAagtgcca	7	GUCACUGA	m6b	Disrupted	-0.065000	no TS	0.510000
hsa-miR-639	gaaaacCAGCGAagtgcca	0	AUCGCUGC	m6b	Created	no TS	-0.193000	-8.570000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.100389780A>G			COSN9199604		AOCS-146-1-9		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1255b-2-3p	attagagAAGTGGTTctgg	0	AACCACUU	m8a	Created	no TS	-0.098000	-10.670000
hsa-miR-942	attAGAGAAGtggttctgg	0	UCUUCUCU	m7b	(m6c->m7b)	no TS	-0.122000	-2.700000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.100389898T>G			COSN8791020		SS6003111		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-208a	acactaaaCGTCTTAacga	0	AUAAGACG	m7b	Created	no TS	-0.246000	-5.240000
hsa-miR-208b	acactaaaCGTCTTAacga	0	AUAAGACG	m7b	Created	no TS	-0.267000	-1.730000
hsa-miR-3653	acactaaaCTTCTTAacga	2	CUAAGAAG	m7b	Disrupted	-0.163000	no TS	0.870000
hsa-miR-3658	acactaaacTTCTTAAcga	3	UUUAAGAA	m7b	(m7b->m6b)	0.022000	no TS	0.140000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.100390050A>G			COSN7590054		8062308		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-616-3p	gactgatgAATGACaacat	3	AGUCAUUG	m6b	Disrupted	-0.068000	no TS	0.350000
hsa-miR-668	gactgatGAGTGACAacat	0	UGUCACUC	m8a	Created	no TS	-0.365000	-10.070000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.100390232G>A			COSN9199605		AOCS-166-1-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
100389372	rs56699628	G	G	hsa-miR-141-3p hsa-miR-200a-3p	1 1	agCAGTGTTAagt agCAGTGTTAagt	Disrupted Disrupted	N N	-0.155 -0.155
			C	hsa-miR-208a-3p hsa-miR-208b-3p hsa-miR-4432 hsa-miR-499a-5p hsa-miR-8087	1 1 1 1 1	agcaGTCTTAAgt agcaGTCTTAAgt agcAGTCTTAagt agcAGTCTTAAgt agcAGTCTTAagt	Created Created Created Created Created	N N N N N	-0.032 -0.032 -0.047 -0.127 -0.038
100389394	rs142882034	T	T	hsa-miR-181b-3p hsa-miR-4420 hsa-miR-653-3p hsa-miR-6837-3p	7 7 6 7	aacCAGTGAAgtg aacCAGTGAAgtg aaCCAGTGAAgtg aaccAGTGAAGtg	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.061 -0.065 -0.3 -0.056
			C	hsa-miR-639	7	aacCAGCGAAgtg	Created	N	-0.193

Genome Browser