SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001256348
Gene Symbol: SEMA5B
Description: Homo sapiens sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B (SEMA5B), transcript variant 1, mRNA.
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.122909255G>A COSN8488048 227_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-20b-3p tcacaatttACTACAGcaa
 0 ACUGUAGU m7b (m6b->m7b) no TS -0.210000 -0.010000
hsa-miR-3137 tcacaatttGCTACAGcaa
 0 UCUGUAGC m7b (m7b->m6b) -0.264000 no TS -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.122909282T>A ICGC_733730B2-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-147a cacacacaCACACACacgc
 0 GUGUGUGG m7a Created -0.098 -0.098 -0.12
hsa-miR-4658 cacacACACTCACacacgc
 0 GUGAGUGU m8a Disrupted -0.139 no TS 0.64
hsa-miR-4758-5p cacacaCACTCACacacgc
 0 GUGAGUGG m7a Disrupted NA NA 15.75
hsa-miR-574-5p cacaCACACTCAcacacgc
 0 UGAGUGUG m8a Disrupted -0.449 no TS -3.22

Mutation Mutation ID Sample Name Cancer Type
chr3:g.122909741C>T COSN1266401 HX10T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1207-3p ggccttctCCAGCTGgccc
 0 UCAGCUGG m7b Disrupted -0.108000 no TS 0.230000
hsa-miR-1253 ggcCTTCTCTagctggccc
 0 AGAGAAGA m7a (m6b->m7a) NA NA -0.340000
hsa-miR-3123 ggccTTCTCTagctggccc
 0 CAGAGAAU m6b Created no TS 0.025000 -0.030000
hsa-miR-3135b ggccttCTCCAGCtggccc
 0 GGCUGGAG m7b Disrupted -0.146000 no TS 0.010000
hsa-miR-3925-5p ggccTTCTCTagctggccc
 0 AAGAGAAC m6b Created no TS 0.018000 -0.020000
hsa-miR-4434 ggcCTTCTCCagctggccc
 0 AGGAGAAG m7b (m7b->m6c) -0.122000 no TS 2.130000
hsa-miR-4516 ggcCTTCTCCagctggccc
 0 GGGAGAAG m7b (m7b->m6c) -0.101000 no TS 2.260000
hsa-miR-4531 ggccTTCTCCAgctggccc
 0 AUGGAGAA m7b Disrupted 0.011000 no TS 2.330000
hsa-miR-5703 ggcCTTCTCCagctggccc
 0 AGGAGAAG m7b (m7b->m6c) -0.122000 no TS 2.560000
hsa-miR-1207-3p ggccttctCCAGCTGgccc
 0 UCAGCUGG m7b Disrupted -0.108 no TS 0.23
hsa-miR-1253 ggcCTTCTCTagctggccc
 0 AGAGAAGA m7a (m6b->m7a) NA NA -0.34
hsa-miR-3123 ggccTTCTCTagctggccc
 0 CAGAGAAU m6b Created no TS 0.025 -0.03
hsa-miR-3135b ggccttCTCCAGCtggccc
 0 GGCUGGAG m7b Disrupted -0.146 no TS 0.01
hsa-miR-3925-5p ggccTTCTCTagctggccc
 0 AAGAGAAC m6b Created no TS 0.018 -0.02
hsa-miR-4434 ggcCTTCTCCagctggccc
 0 AGGAGAAG m7b (m7b->m6c) -0.122 no TS 2.13
hsa-miR-4516 ggcCTTCTCCagctggccc
 0 GGGAGAAG m7b (m7b->m6c) -0.101 no TS 2.26
hsa-miR-4531 ggccTTCTCCAgctggccc
 0 AUGGAGAA m7b Disrupted 0.011 no TS 2.33
hsa-miR-5703 ggcCTTCTCCagctggccc
 0 AGGAGAAG m7b (m7b->m6c) -0.122 no TS 2.56

Mutation Mutation ID Sample Name Cancer Type
chr3:g.122909918G>T COSN6748080 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3661 ttcagcCCAGGTCtctcat
 0 UGACCUGG m7b Disrupted -0.193000 no TS No effect
hsa-miR-378g ttcAGCCCAGgtctctcat
 0 ACUGGGCU m7b (m7b->m6c) -0.141000 no TS 0.020000
hsa-miR-631 ttcagcCCAGGTCTctcat
 0 AGACCUGG m8a Disrupted -0.193000 no TS No effect
hsa-miR-769-5p ttcagcccAGGTCTCtcat
 0 UGAGACCU m7b Disrupted -0.128000 no TS 0.140000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.122910024G>A COSN1266402 HCC132T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4708-3p tgctGCCTTGCctgtgggg
 0 AGCAAGGC m7b Disrupted -0.382000 -0.175000 13.360000
hsa-miR-4742-5p tgctgccTTGCCTGtgggg
 0 UCAGGCAA m7b Disrupted -0.063000 no TS 0.530000
hsa-miR-4708-3p tgctGCCTTGCctgtgggg
 0 AGCAAGGC m7b Disrupted -0.382000 -0.175000 13.360000
hsa-miR-4742-5p tgctgccTTGCCTGtgggg
 0 UCAGGCAA m7b Disrupted -0.063000 no TS 0.530000
hsa-miR-4708-3p tgctGCCTTGCctgtgggg
 0 AGCAAGGC m7b Disrupted -0.382 -0.175 13.36
hsa-miR-4742-5p tgctgccTTGCCTGtgggg
 0 UCAGGCAA m7b Disrupted -0.063 no TS 0.53

Mutation Mutation ID Sample Name Cancer Type
chr3:g.122910058C>T COSN9735790 C0062T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3148 tttggtTTTTTCCctctgc
 0 UGGAAAAA m7b Created no TS -0.024000 -4.210000
hsa-miR-4419a tttggttttCTCCCTCtgc
 0 UGAGGGAG m7b (m7b->m6b) -0.232000 no TS 1.700000
hsa-miR-4510 tttggttttCTCCCTCtgc
 0 UGAGGGAG m7b (m7b->m6b) -0.223000 no TS 0.350000
hsa-miR-4668-5p tttggttTTTTCCCTctgc
 0 AGGGAAAA m8a Created no TS -0.125000 -2.820000
hsa-miR-548aa ttTGGTTTTTtccctctgc
 0 AAAAACCA m8a (m7b->m8a) -0.054000 -0.081000 -0.030000
hsa-miR-548ac tttGGTTTTTtccctctgc
 0 CAAAAACC m7b (m6c->m7b) no TS -0.032000 2.540000
hsa-miR-548ap-3p ttTGGTTTTTtccctctgc
 0 AAAAACCA m8a (m7b->m8a) -0.054000 -0.081000 -0.030000
hsa-miR-548d-3p tttGGTTTTTtccctctgc
 0 CAAAAACC m7b (m6c->m7b) no TS -0.041000 -1.570000
hsa-miR-548h-3p tttGGTTTTTtccctctgc
 0 CAAAAACC m7b (m6c->m7b) no TS -0.032000 1.040000
hsa-miR-548t-3p ttTGGTTTTTtccctctgc
 0 AAAAACCA m8a (m7b->m8a) -0.054000 -0.081000 -0.030000
hsa-miR-548z tttGGTTTTTtccctctgc
 0 CAAAAACC m7b (m6c->m7b) no TS -0.032000 1.040000
hsa-miR-5584-5p tttggtttTTTCCCTctgc
 0 CAGGGAAA m7b Created no TS -0.150000 1.260000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.122910059T>A COSN9735791 C0062T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548aa gttTGGTTTTctccctctg
 0 AAAAACCA m7b (m7b->m6c) -0.054000 no TS -0.170000
hsa-miR-548ap-3p gttTGGTTTTctccctctg
 0 AAAAACCA m7b (m7b->m6c) -0.054000 no TS -5.270000
hsa-miR-548t-3p gttTGGTTTTctccctctg
 0 AAAAACCA m7b (m7b->m6c) -0.054000 no TS -0.170000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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