SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_001030060
Gene Symbol:	SAMD5
Description:	Homo sapiens sterile alpha motif domain containing 5 (SAMD5), mRNA.
Gene Location:	chr6(+):147829827-147891157
Browse Associations

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147564631G>A			COSN8493798		1848_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-223-3p	gggtAACTGACttataaca	0	UGUCAGUU	m7b	Created	no TS	-0.212000	No effect
hsa-miR-224-5p	gggtaacTGACTTataaca	0	CAAGUCAC	m6b	Created	-0.046000	-0.153000	No effect
hsa-miR-4676-5p	gggtaACTGGCTtataaca	2	GAGCCAGU	m7b	Disrupted	-0.285000	-0.011000	No effect
hsa-miR-575	gggtaACTGGCTtataaca	2	GAGCCAGU	m7b	Disrupted	-0.295000	-0.002000	0.220000
hsa-miR-935	ggGTAACTGGcttataaca	4	CCAGUUAC	m8a	(m8a->m7a)	-0.105000	-0.250000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147564679T>G			COSN4856585		tumor_4121361		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1248	ataAAGAAGGattgagttc	1	ACCUUCUU	m7b	(m6b->m7b)	0.047000	-0.248000	-0.010000
hsa-miR-3682-5p	ataaAGAAGTAttgagttc	2	CUACUUCU	m7b	Disrupted	-0.204000	0.006000	-0.010000
hsa-miR-500a-5p	ataaagAAGGATTgagttc	6	UAAUCCUU	m7b	Created	0.020000	-0.099000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147565168C>A			COSN14972792		LP6005409-DNA_E01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4666b	tctgACATGCAtcaagcaa	0	UUGCAUGU	m7b	Disrupted	-0.077000	no TS	4.560000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147565359A>C			COSN8493799		1255_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3168	tgTAGAACTCcggctgaaa	0	GAGUUCUA	m8a	(m7a->m8a)	0.046000	0.092000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147565513T>C			ICGC_7BADAECE-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1273g-3p	gctggagtGCAGTGGcaca	0	ACCACUGC	m7b	Created	0.02	-0.139	-1.03
hsa-miR-4252	gctggagtgCAGTGGCaca	0	GGCCACUG	m7b	(m6c->m7b)	-0.034	-0.14	No effect
hsa-miR-4793-3p	gctggAGTGCAGtggcaca	0	UCUGCACU	m7b	Created	-0.02	0.002	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147565582T>C			COSN14798306		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1911-3p	ctcggcctCCTGGTagctg	0	CACCAGGC	m6b	Created	no TS	-0.002000	No effect
hsa-miR-4459	ctcggCCTCCTGGtagctg	1	CCAGGAGG	m8a	Created	0.057000	0.064000	-2.070000
hsa-miR-4695-5p	ctcgGCCTCCTGgtagctg	0	CAGGAGGC	m8a	Created	no TS	-0.014000	-0.040000
hsa-miR-665	ctcggcCTCCTGGTagctg	1	ACCAGGAG	m8a	Created	-0.372000	-0.400000	-2.090000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147565604C>T			COSN8399111		tumor_4166706		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1271-3p	ttaCAGGCACgcatcacca	2	AGUGCCUG	m7b	(m7b->m6b)	-0.229000	-0.137000	0.990000
hsa-miR-550a-3-5p	ttaCAGGCACgcatcacca	2	AGUGCCUG	m7b	(m7b->m6b)	-0.213000	-0.140000	0.010000
hsa-miR-550a-5p	ttaCAGGCACgcatcacca	2	AGUGCCUG	m7b	(m7b->m6b)	-0.213000	-0.140000	0.080000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147565656T>C			ICGC_7BADB39C-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-548aa	atggGGTTTTaccatgttg	0	AAAAACCA	m6b	Disrupted	-0.054	-0.143	0.42
hsa-miR-548ap-3p	atggGGTTTTaccatgttg	0	AAAAACCA	m6b	Disrupted	-0.054	-0.143	2.16
hsa-miR-548as-3p	atgGGGTTTTAccatgttg	0	UAAAACCC	m8a	Disrupted	0.05	no TS	1.54
hsa-miR-548at-3p	atggGGTTTTaccatgttg	0	CAAAACCG	m6b	Disrupted	0.06	no TS	0.55
hsa-miR-548t-3p	atggGGTTTTaccatgttg	0	AAAAACCA	m6b	Disrupted	-0.054	-0.143	0.42

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147565808T>C			COSN6307793		RK136_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1247-5p	ccatgttGACGGGaccaaa	0	ACCCGUCC	m6b	Created	no TS	-0.119000	-0.470000
hsa-miR-4281	ccatgttgaCGGGACCaaa	3	GGGUCCCG	m7b	(m6c->m7b)	-0.122000	-0.267000	-0.560000
hsa-miR-505-3p	ccaTGTTGACGggaccaaa	2	CGUCAACA	m8a	Created	-0.155000	-0.146000	-0.680000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147566241A>G			COSN6307794		RK176_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3140-3p	aaattataCAAAAGCTttt	2	AGCUUUUG	m8a	Disrupted	0.014000	0.062000	-0.010000
hsa-miR-3149	aaattATACAAAagctttt	0	UUUGUAUG	m7a	Disrupted	0.379000	0.277000	0.220000
hsa-miR-568	aaaTTATACAaaagctttt	0	AUGUAUAA	m7b	(m7b->m6b)	0.161000	0.080000	0.640000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147566433C>T			COSN14737280		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-449b-3p	tgtcgcatcTGTGGCTGat	0	CAGCCACA	m8a	(m7b->m8a)	no TS	-0.022000	0.020000
hsa-miR-5683	tgtcgCATCTGTggctgat	0	UACAGAUG	m7b	Created	no TS	0.127000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147567171T>C			COSN15080174		SM-4B296		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4480	aaagatttCTTGGCatagg	7	AGCCAAGU	m6b	Disrupted	-0.205000	-0.164000	0.510000
hsa-miR-4755-3p	aaagatttCCTGGCatagg	2	AGCCAGGC	m6b	Created	-0.126000	-0.176000	-0.010000
hsa-miR-5006-5p	aaagatttCCTGGCAtagg	0	UUGCCAGG	m7b	Created	no TS	-0.097000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147567294C>T			COSN4953324		SS6003323		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5007-3p	gggagCATATGAgcaattt	4	AUCAUAUG	m7b	Created	0.117000	0.240000	-0.840000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147567791C>T			COSN14877203		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1200	gatttctCTCAGGAaggat	0	CUCCUGAG	m7b	Disrupted	-0.022000	no TS	No effect
hsa-miR-378a-5p	gatttctcTCAGGAaggat	2	CUCCUGAC	m6b	Disrupted	0.010000	-0.015000	No effect
hsa-miR-3925-5p	gatTTCTCTTaggaaggat	0	AAGAGAAC	m7a	(m6a->m7a)	NA	NA	No effect
hsa-miR-4251	gatttcTCTCAGGaaggat	0	CCUGAGAA	m7a	Disrupted	0.053000	0.053000	0.010000
hsa-miR-4324	gatttcTCTCAGGaaggat	0	CCCUGAGA	m7b	Disrupted	-0.010000	no TS	0.050000
hsa-miR-4329	gatttcTCTCAGGaaggat	0	CCUGAGAC	m7a	Disrupted	0.041000	0.041000	No effect
hsa-miR-544b	gatttctCTCAGGaaggat	0	ACCUGAGG	m6b	Disrupted	0.015000	no TS	0.880000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147567852G>A			COSN9969969		C0098T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1298	ttattgattGAATGAAaag	8	UUCAUUCG	m7a	(m7a->m6b)	0.030000	no TS	0.160000
hsa-miR-4272	ttattgaTTGAATGaaaag	3	CAUUCAAC	m7a	Disrupted	0.074000	0.074000	0.010000
hsa-miR-4705	ttatTGATTGAatgaaaag	6	UCAAUCAC	m7a	Disrupted	0.023000	no TS	0.060000
hsa-miR-4729	ttattgatTAAATGAaaag	14	UCAUUUAU	m7a	Created	-0.068000	0.065000	No effect
hsa-miR-5696	ttattgatTAAATGAaaag	3	CUCAUUUA	m7b	Created	0.184000	0.359000	No effect
hsa-miR-579	ttattgattAAATGAAaag	3	UUCAUUUG	m7a	(m6b->m7a)	0.493000	0.585000	-0.010000
hsa-miR-644b-3p	ttattgattAAATGAAaag	3	UUCAUUUG	m7a	(m6b->m7a)	0.554000	0.670000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147567892T>G			ICGC_D03274F2-2A78-11E2-951E-21FD496BB9B8		CPCG_0103_Pr_P_P5		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2392	aacactCCATCCTgggcaa	2	UAGGAUGG	m7b	Disrupted	0.01	no TS	No effect
hsa-miR-3135b	aacaCTCCAGCCtgggcaa	0	GGCUGGAG	m8a	Created	-0.004	-0.033	No effect
hsa-miR-3652	aacacTCCAGCCtgggcaa	0	CGGCUGGA	m7b	Created	-0.015	-0.024	-0.44
hsa-miR-4430	aacacTCCAGCCTgggcaa	0	AGGCUGGA	m8a	Created	-0.015	-0.005	-4.13
hsa-miR-4534	aacaCTCCATCCtgggcaa	2	GGAUGGAG	m8a	Disrupted	-0.004	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147568139G>T			COSN14714085		CHC433T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4690-3p	agtgcaaaTGGGCTGttcc	1	GCAGCCCA	m7b	Disrupted	-0.071000	no TS	4.470000
hsa-miR-5685	agtgcaaaTGGGCTGTtcc	1	ACAGCCCA	m8a	Disrupted	-0.062000	no TS	6.360000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147568663G>T			COSN7693554		8057574		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4719	atcaaatgATTTGTGcaga	0	UCACAAAU	m7b	Created	no TS	0.095000	-1.600000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.147569700G>A			COSN4856586		tumor_4158726		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3140-5p	atactATTCAGGTtgctaa	2	ACCUGAAU	m8a	Created	0.008000	-0.164000	-0.030000
hsa-miR-4427	atacTATTCAGgttgctaa	0	UCUGAAUA	m7b	Created	no TS	-0.085000	-0.900000
hsa-miR-5585-3p	ataCTATTCAGgttgctaa	1	CUGAAUAG	m8a	Created	-0.030000	-0.154000	-0.470000

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
147565582	rs702344	C
147565582	rs702344	C	C	hsa-miR-1911-3p hsa-miR-4459 hsa-miR-4695-5p hsa-miR-665 hsa-miR-6753-5p	0	ggcctCCTGGTAg ggCCTCCTGgtag gGCCTCCTggtag ggcCTCCTGGtag ggcctCCTGGTAg	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.002 0.007 -0.014 -0.028 -0.013
147565591	rs138900019	G	G	hsa-miR-5690 hsa-miR-7977	2 2	GTAGCTGggatta gtaGCTGGGAtta	Disrupted Disrupted	N N	0.03 -0.083
147565591	rs138900019	G	A	hsa-miR-500a-5p	2	gtagctAGGATTA	Created	N	0.061
147565862	rs79079598	A	T	hsa-miR-4676-5p hsa-miR-505-5p hsa-miR-575	0	tacaACTGGCTcc tacaacTGGCTCC tacaACTGGCTcc	Created Created Created	N N N	-0.011 -0.062 -0.002
147565862	rs79079598	A	A	hsa-miR-3613-5p	0	TACAACAggctcc	Disrupted	N	0.001
147566213	rs117369381	G	G	hsa-miR-3140-3p	4	ttAAAAGCAtgta	Disrupted	N	0.063
147566213	rs117369381	G	A	hsa-miR-4307 hsa-miR-4666a-5p	3 5	ttaAAAACATgta ttaaaaACATGTA	Created Created	N N	0.061 -0.029
147566214	rs139554961	C	C	hsa-miR-3140-3p	4	tAAAAGCAtgtat	Disrupted	N	0.063
147566214	rs139554961	C	T	hsa-miR-5003-3p	4	tAAAAGTAtgtat	Created	N	0.11
147566382	rs185681835	A	A	hsa-miR-95-5p	12	taaTTTATTGtga	Disrupted	N	0.065
147566382	rs185681835	A	T	hsa-miR-3613-3p hsa-miR-4719	12 11	taaTTTTTTGtga taatttTTTGTGA	Created Created	N N	0.159 0.065
147566433	rs702347	T
147566433	rs702347	T	T	hsa-miR-449b-3p hsa-miR-5683	0	cgcatcTGTGGCT cgCATCTGTggct	Disrupted Disrupted	N N	-0.022 0.127
147566718	rs183612268	A
147566718	rs183612268	A	G	hsa-miR-1273g-3p hsa-miR-181a-2-3p hsa-miR-6509-3p hsa-miR-892b	4 4 4 4	aagcCAGTGGAtt aagcCAGTGGAtt aagcCAGTGGAtt aAGCCAGTggatt	Created Created Created Created	N N N N	-0.016 -0.031 -0.03 -0.11
147567660	rs41285883	T	T	hsa-miR-186-5p hsa-miR-3133	4 4	ccTTCTTTActct ccTTCTTTActct	Disrupted Disrupted	N N	0.204 0.191
147567660	rs41285883	T	C	hsa-miR-3123 hsa-miR-3925-5p hsa-miR-6770-5p hsa-miR-6832-5p	4 4 5 3	ccTTCTCTActct ccTTCTCTActct CCTTCTCtactct cctTCTCTACtct	Created Created Created Created	N N N N	0.118 0.108 0.057 0.028
147567791	rs702351	T	C	hsa-miR-1200 hsa-miR-378a-5p hsa-miR-4324 hsa-miR-544b hsa-miR-6761-5p	0	ttctCTCAGGAAg ttctcTCAGGAAg ttcTCTCAGGAag ttctCTCAGGAag ttCTCTCAGgaag	Created Created Created Created Created	N N N N N	-0.022 0.025 -0.01 0.015 -0.017
147567791	rs702351	T
147568139	rs77599373	G	G	hsa-miR-4690-3p hsa-miR-5685 hsa-miR-6856-3p	1 1 1	gcaaaTGGGCTGt gcaaaTGGGCTGt gcaaatGGGCTGT	Disrupted Disrupted Disrupted	N N N	-0.071 -0.062 -0.077
147568139	rs77599373	G
147568274	rs189779134	G
147568274	rs189779134	G	C	hsa-miR-5007-3p	2	aaaattCATATGA	Created	N	0.054
147569072	rs200421592	-	-	hsa-miR-129-5p hsa-miR-3149	0	aaaataCAAAAAA aaaATACAAAaaa	Unknown Unknown	N N	0.003 0.003
147569072	rs200421592	-	A
147569073	rs34834946	-	-	hsa-miR-129-5p hsa-miR-3149	0	aaataCAAAAAAa aaATACAAAaaaa	Unknown Unknown	N N	0.003 0.003
147569073	rs34834946	-	A
147569611	rs6903802	T	T	hsa-miR-505-3p	2	gtggtaTGTTGAC	Disrupted	N	-0.147
147569611	rs6903802	T

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser