SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_006914
Gene Symbol: RORB
Description: Homo sapiens RAR-related orphan receptor B (RORB), mRNA.
Gene Location: chr9(+):77112251-77302117
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr9:g.74685696G>A COSN7572001 8057501 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr9:g.74685881G>A COSN5814705 EOPC-01_tumor [prostate][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3140-5p attttATTCAGGTatgttt
 0 ACCUGAAU m8a Created no TS -0.271000 -0.200000
hsa-miR-4427 atttTATTCAGgtatgttt
 0 UCUGAAUA m7b Created no TS -0.151000 -0.250000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.74686139T>C COSN9318691 4132_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-210 acttatacACGCACAtgca
 0 CUGUGCGU m7b Created no TS -0.227000 -5.000000
hsa-miR-4666b acttatACATGCAcatgca
 0 UUGCAUGU m7b Disrupted -0.333000 -0.109000 No effect
hsa-miR-5011-3p acttataCATGCACatgca
 0 GUGCAUGG m7a Disrupted NA NA -0.170000
hsa-miR-568 acTTATACATgcacatgca
 0 AUGUAUAA m8a (m8a->m7a) -0.172000 -0.145000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr9:g.74686405T>C COSN2327223 RK066_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-323b-3p gatggttcaTATTGGGaag
 0 CCCAAUAC m7a (m7a->m6b) NA NA 0.390000
hsa-miR-4517 gatggtTCATATTgggaag
 1
 AAAUAUGA m7b Disrupted 0.046000 -0.001000 0.050000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.74686551G>T COSN7809887 PCSI_0109_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3613-3p ttttcTTTTTGatttctgg
 19
 ACAAAAAA m6b Created 0.198000 0.264000 -0.020000
hsa-miR-551b-5p ttttctttTTGATTTCtgg
 0 GAAAUCAA m8a Created 0.131000 0.140000 -0.070000


Mutation Mutation ID Sample Name Cancer Type
chr9:g.74686593T>C COSN14739003 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr9:g.74686641T>G COSN14945609 LP6005409-DNA_G03 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-570-3p ccagcaatTGTTTTCtagg
 0 CGAAAACA m7b Created 0.068000 0.007000 -0.300000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.74687124T>A COSN2327224 RK165_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2682-5p gaaatttgtACTGCCTGtg
 0 CAGGCAGU m8a (m7b->m8a) no TS -0.259000 1.180000
hsa-miR-34b-5p gaaatttgtACTGCCTgtg
 0 UAGGCAGU m7b (m6c->m7b) no TS -0.250000 0.090000
hsa-miR-449c-5p gaaatttgtACTGCCTgtg
 0 UAGGCAGU m7b (m6c->m7b) no TS -0.240000 0.700000
hsa-miR-589-3p gaaattTGTTCTGcctgtg
 8
 UCAGAACA m7b Disrupted -0.165000 no TS 0.130000
hsa-miR-7-1-3p gaaATTTGTTctgcctgtg
 4
 CAACAAAU m7b (m7b->m6b) -0.136000 -0.100000 0.020000
hsa-miR-7-2-3p gaaATTTGTTctgcctgtg
 4
 CAACAAAU m7b (m7b->m6b) -0.125000 -0.089000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.74687190A>G COSN5705135 RK088_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
74686120 rs191611722 T T hsa-miR-410-3p
hsa-miR-5011-5p
18
16
 aTTATATAtgact
atTATATATgact
 Disrupted
Disrupted
N
N
 0.041
-0.018
C hsa-miR-568
hsa-miR-6516-3p
18
14
 aTTATACAtgact
attaTACATGAct
 Created
Created
N
N
 -0.11
-0.167
74686145 rs184145958 T T hsa-miR-148a-3p
hsa-miR-148b-3p
hsa-miR-152-3p
hsa-miR-4666b
15
15
15
11
 tgcacaTGCACTG
tgcacaTGCACTG
tgcacaTGCACTG
tgcACATGCActg
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.156
-0.156
-0.156
-0.144
G hsa-miR-1271-3p
hsa-miR-1914-5p
hsa-miR-214-5p
hsa-miR-33b-3p
hsa-miR-515-3p
hsa-miR-519e-3p
hsa-miR-550a-3-5p
hsa-miR-550a-5p
hsa-miR-6514-3p
hsa-miR-6811-3p
15
10
11
16
16
16
15
15
11
11
 tgcaCAGGCACtg
tGCACAGGcactg
tgcACAGGCActg
tgcacAGGCACTg
tgcacAGGCACTg
tgcacAGGCACTg
tgcaCAGGCACtg
tgcaCAGGCACtg
tgcACAGGCActg
tgCACAGGCActg
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
 -0.224
-0.186
-0.118
-0.167
-0.157
-0.157
-0.224
-0.224
-0.113
-0.312

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