SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001242844
Gene Symbol:	RNF146
Description:	Homo sapiens ring finger protein 146 (RNF146), transcript variant 1, mRNA.
Gene Location:	chr6(+):127587882-127609705
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.127287731G>T			COSN8493601		824_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-652-5p	ggttgaaAGGGTTacctgt	0	CAACCCUA	m6b	Disrupted	-0.155000	no TS	2.840000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.127288310T>A			COSN2140278		RK032_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-577	tctgcaTTTATCTttttga	0	UAGAUAAA	m7b	Created	no TS	-0.099000	-1.010000
hsa-miR-577	tctgcaTTTATCTttttga	0	UAGAUAAA	m7b	Created	no TS	-0.099000	-1.010000
hsa-miR-577	tctgcaTTTATCTttttga	0	UAGAUAAA	m7b	Created	no TS	-0.099	-1.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.127288335T>G			COSN8493602		J36_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-944	aatttATAATTTaataaat	1	AAAUUAUU	m7a	Disrupted	0.025000	0.025000	1.638600

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
127287735	rs75562683	A	A	hsa-miR-552-3p hsa-miR-652-5p hsa-miR-6732-3p	4 1 1	agggttACCTGTA AGGGTTAcctgta AGGGTTAcctgta	Disrupted Disrupted Disrupted	N N N	-0.145 -0.155 -0.14
			G	hsa-miR-4438 hsa-miR-4742-5p hsa-miR-5095 hsa-miR-7151-3p	4 2 4 4	agggttGCCTGTA agggTTGCCTGta agggttGCCTGTA agggttGCCTGTA	Created Created Created Created	N N N N	-0.167 -0.178 -0.305 -0.277

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