SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_021205
Gene Symbol:	RHOU
Description:	Homo sapiens ras homolog gene family, member U (RHOU), transcript variant 1, mRNA.
Gene Location:	chr1(+):228870823-228882416
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228743763G>T			COSN8637622		J30_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3121-3p	cccagaaagTCTATTTtca	2	UAAAUAGA	m7b	(m6c->m7b)	0.110000	0.072000	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228744009A>G			COSN1434790		RK002_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-551b-5p	cctctggTTGATTTatatc	0	GAAAUCAA	m7b	Created	0.010000	-0.066000	-0.020000
hsa-miR-551b-5p	cctctggTTGATTTatatc	0	GAAAUCAA	m7b	Created	0.010000	-0.066000	-0.020000
hsa-miR-551b-5p	cctctggTTGATTTatatc	0	GAAAUCAA	m7b	Created	0.01	-0.066	-0.02

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228744388C>T			COSN6446296		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-561-3p	aggAAACTTTcttattggg	0	CAAAGUUU	m7b	(m6b->m7b)	no TS	0.043000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228744549G>A			COSN6446297		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4666b	ctgtaatACATGCAccaaa	5	UUGCAUGU	m7b	Created	-0.104000	-0.212000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228744719G>A			COSN6446298		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228744771A>G			COSN6025977		RK201_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3924	cacacagATACATAggtct	6	AUAUGUAU	m7b	Disrupted	0.106000	-0.003000	0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228745092G>A			COSN8437037		AOCS-096-1-7		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1913	ctgaGGGGCAGggcgtgta	0	UCUGCCCC	m7b	Created	no TS	0.007000	-0.590000
hsa-miR-3173-5p	ctgagggGCAGGGCgtgta	2	UGCCCUGC	m7b	Created	-0.045000	-0.039000	-0.450000
hsa-miR-324-3p	ctgaGGGGCAGggcgtgta	0	ACUGCCCC	m7b	Created	no TS	-0.002000	-0.570000
hsa-miR-4749-3p	ctGAGGGGCGgggcgtgta	0	CGCCCCUC	m8a	(m8a->m7a)	-0.018000	-0.115000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228745194T>C			COSN7207095		8051974		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4665-3p	tgttagGGCCGAatcttct	2	CUCGGCCG	m6b	Created	-0.302000	-0.469000	No effect
hsa-miR-4687-5p	tgttAGGGCTGaatcttct	5	CAGCCCUC	m7a	Disrupted	-0.175000	-0.175000	No effect
hsa-miR-4690-3p	tgttaGGGCTGaatcttct	2	GCAGCCCA	m6b	Disrupted	-0.054000	no TS	1.240000
hsa-miR-5685	tgttaGGGCTGaatcttct	2	ACAGCCCA	m6b	Disrupted	-0.048000	no TS	1.760000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228745382A>G			COSN6446299		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3163	gatagaagaATTTTATttt	3	UAUAAAAU	m7b	(m7b->m6c)	0.574000	0.419000	No effect
hsa-miR-4659a-3p	gatAGAAGAAttttatttt	0	UUUCUUCU	m7b	(m7b->m6b)	-0.026000	no TS	0.120000
hsa-miR-4659b-3p	gatAGAAGAAttttatttt	0	UUUCUUCU	m7b	(m7b->m6b)	-0.026000	no TS	0.050000
hsa-miR-548a-3p	gatagaagAGTTTTatttt	2	CAAAACUG	m6b	Created	-0.028000	0.078000	0.130000
hsa-miR-548e	gatagaagAGTTTTatttt	2	AAAAACUG	m6b	Created	-0.013000	0.090000	-0.880000
hsa-miR-548f	gatagaagAGTTTTatttt	2	AAAAACUG	m6b	Created	-0.009000	0.097000	-0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228745561A>G			COSN6025978		RK205_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-140-5p	ctttaAACCACTaaaatac	5	CAGUGGUU	m7b	Disrupted	-0.210000	no TS	No effect
hsa-miR-3545-5p	ctttaaACCACTAaaatac	5	UAGUGGUC	m7a	Disrupted	-0.112000	no TS	0.110000
hsa-miR-3591-5p	ctttaaacCACTAAAatac	5	UUUAGUGU	m7a	Disrupted	-0.028000	no TS	0.310000
hsa-miR-4321	ctttaaACCGCTAAaatac	0	UUAGCGGU	m8a	Created	no TS	-0.414000	-0.010000
hsa-miR-4460	ctttaaACCACTAaaatac	4	AUAGUGGU	m7b	Disrupted	-0.270000	no TS	0.240000
hsa-miR-4727-3p	ctttaaaCCACTAaaatac	4	AUAGUGGG	m6b	Disrupted	-0.099000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.228746421T>A			COSN8437038		AOCS-155-3-5		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
228743761	rs199588595	A	A	hsa-miR-3614-3p	2	ccagaAAGGCTAt	Disrupted	N	-0.176
			G	hsa-miR-1237-3p hsa-miR-129-1-3p hsa-miR-129-2-3p hsa-miR-3651 hsa-miR-4687-5p hsa-miR-5088-3p hsa-miR-6779-3p hsa-miR-6886-3p	3 2 2 2 2 3 2 4	cCAGAAGGgctat ccagAAGGGCTAt ccagAAGGGCTAt ccagaaGGGCTAT ccagaAGGGCTAt ccAGAAGGGctat ccagaAGGGCTAt ccaGAAGGGCtat	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.146 -0.378 -0.399 -0.34 -0.212 -0.161 -0.202 -0.296
228744206	rs3203167	C	C	hsa-miR-3680-3p hsa-miR-4666b hsa-miR-5011-3p hsa-miR-5087	5 5 4 5	tccATGCAAAcca tcCATGCAAacca tCCATGCAAacca tccatgCAAACCA	Disrupted Disrupted Disrupted Disrupted	N N N N	0.013 -0.104 -0.34 -0.084
			T	hsa-miR-299-5p hsa-miR-4666a-5p hsa-miR-4802-3p hsa-miR-942-3p	2 5 5 5	tccatGTAAACCA tcCATGTAAacca TCCATGTAaacca tCCATGTAaacca	Created Created Created Created	N N N N	-0.245 -0.049 -0.271 -0.099
228744388	rs11583565	-	C	hsa-miR-651-3p	0	aaacTTCCTTAtt	Unknown	N	-0.007
			T	hsa-miR-561-3p	0	AAACTTTcttatt	Unknown	N	0.043
228744549	rs41271473	G
			A	hsa-miR-4666b	1	taatACATGCAcc	Created	N	-0.108
228745046	rs116542113	G	G	hsa-miR-146b-3p hsa-miR-18a-3p hsa-miR-3173-5p hsa-miR-345-3p hsa-miR-6799-3p hsa-miR-7976 hsa-miR-874-3p	2 2 2 4 2 2 2	tttCAGGGCAgta tttcAGGGCAGta tttCAGGGCAgta tTTCAGGGcagta tttCAGGGCAgta ttTCAGGGCAgta tttCAGGGCAgta	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.049 -0.028 -0.045 -0.006 -0.042 -0.133 -0.068
			A	hsa-miR-146a-3p hsa-miR-3194-3p hsa-miR-4766-5p hsa-miR-5691 hsa-miR-6805-3p	4 2 4 2 2	tTTCAGAGcagta tttCAGAGCAgta TTTCAGAgcagta tttCAGAGCAgta tttCAGAGCAgta	Created Created Created Created Created	N N N N N	0.059 0.004 0.01 -0.022 -0.022
228745382	rs13349	G	A	hsa-miR-3163 hsa-miR-4282 hsa-miR-4659a-3p hsa-miR-4659b-3p	1 1 0 0	agaagaATTTTAT agaagAATTTTAt AGAAGAAttttat AGAAGAAttttat	Created Created Created Created	N N N N	0.155 0.18 -0.026 -0.026
			G	hsa-miR-548a-3p hsa-miR-548ar-3p hsa-miR-548az-3p hsa-miR-548e-3p hsa-miR-548f-3p hsa-miR-5582-3p	1 1 1 1 1 1	agaagAGTTTTAt agaagAGTTTTAt agaagAGTTTTAt agaagAGTTTTAt agaagAGTTTTAt agaagAGTTTTAt	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	0.106 0.099 0.106 0.103 0.106 0.113
228745565	rs144675421	A	A	hsa-miR-3591-5p hsa-miR-4460 hsa-miR-4727-3p	5 4 4	cCACTAAAataca CCACTAAaataca CCACTAAaataca	Disrupted Disrupted Disrupted	N N N	-0.028 -0.091 -0.099
			G	hsa-miR-6080 hsa-miR-630	5 7	cCACTAGAataca ccactAGAATACA	Created Created	N N	-0.09 -0.053
228746108	rs141544566	A	A	hsa-miR-33a-5p hsa-miR-33b-5p	4 4	cctttaAATGCAA cctttaAATGCAA	Disrupted Disrupted	N N	-0.056 -0.056
			C	hsa-miR-4495 hsa-miR-4666b hsa-miR-5011-3p	3 5 5	ccTTTACATgcaa cctttACATGCAA cctttaCATGCAA	Created Created Created	N N N	0.065 -0.281 -0.098
228746218	rs189996789	C	C	hsa-miR-4665-3p hsa-miR-6075 hsa-miR-874-5p	2 2 3	tggGGCCGAAaat tgGGGCCGAaaat TGGGGCCgaaaat	Disrupted Disrupted Disrupted	N N N	-0.302 -0.311 -0.305
			T	hsa-miR-30a-3p hsa-miR-30d-3p hsa-miR-30e-3p hsa-miR-3157-5p hsa-miR-4323 hsa-miR-4690-3p hsa-miR-5685	2 2 2 2 3 2 2	tggggCTGAAAAt tggggCTGAAAAt tggggCTGAAAAt tggGGCTGAAaat TGGGGCTgaaaat tgGGGCTGAaaat tgGGGCTGAaaat	Created Created Created Created Created Created Created	N N N N N N N	-0.003 -0.003 -0.003 -0.169 -0.306 -0.197 -0.211

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