SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_022841
Gene Symbol:	RFX7
Description:	Homo sapiens regulatory factor X, 7 (RFX7), mRNA.
Gene Location:	chr15(-):56382730-56535483
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.56091070T>C			COSN8389639		tumor_4166706		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1278	gtaCAGTACTAggattcct	17	UAGUACUG	m8a	Disrupted	-0.269000	no TS	0.020000
hsa-miR-325	gtacagTACTAGGattcct	0	CCUAGUAG	m7a	Disrupted	NA	NA	0.210000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.56091207T>G			13_120		SJMB016_D		Medulloblastoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5581-3p	aatgtGCATGGAtctcaat	0	UUCCAUGC	m7b	Created	no TS	-0.182	-1.64

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.56091435C>G			COSN15402299		AOCS-092-1-6		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3936	atttttaACCCCTTgtaca	0	UAAGGGGU	m7b	Disrupted	-0.169000	no TS	No effect
hsa-miR-3936	atttttaACCCCTTgtaca	0	UAAGGGGU	m7b	Disrupted	-0.169000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.56092801T>G			COSN8747603		AOCS-034-3-8		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-224-3p	agtACCATTTacacccacg	14	AAAAUGGU	m7b	(m7b->m6c)	-0.064000	0.017000	1.670000
hsa-miR-4694-3p	agtaCCATTTacacccacg	14	CAAAUGGA	m6b	Disrupted	0.059000	0.034000	0.130000
hsa-miR-522-3p	agtACCATTTacacccacg	14	AAAAUGGU	m7b	(m7b->m6c)	-0.096000	-0.025000	0.040000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
56092697	rs199650020	-	-	hsa-miR-224-3p hsa-miR-4694-3p hsa-miR-522-3p	18 18 18	acaagtagCCATTTAta acaagtagCCATTTAta acaagtagCCATTTAta	Unknown Unknown Unknown	N N N	-0.001 0.004 -0.008
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