SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_020975 |
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Gene Symbol: | RET |
Description: | Homo sapiens ret proto-oncogene (RET), transcript variant 4, mRNA. |
Gene Location: | chr10(+):43572516-43625797 |
Browse Associations | |
Browse Pathways |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr10:g.43128312A>G | cosmic_v64_1760532 | Leukemia/T-ALL | |||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4310 |
ggaagaaacATGCTGagaa |
0 | GCAGCAUU | m6b | Disrupted | -0.312 | -0.178 |
0.01 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr10:g.43128432T>C | COSN8640078 | J10_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-548aa |
aggTGGTTTTacttctgat |
0 | AAAAACCA | m7b | (m7b->m6b) | -0.310000 | -0.201000 |
1.830000 |
|
hsa-miR-548ao-5p |
aggtggttTTACTTCTgat |
0 | AGAAGUAA | m8a | Disrupted | -0.126000 | no TS |
0.130000 |
|
hsa-miR-548ap-3p |
aggTGGTTTTacttctgat |
0 | AAAAACCA | m7b | (m7b->m6b) | -0.310000 | -0.201000 |
0.330000 |
|
hsa-miR-548at-3p |
aggtGGTTTTacttctgat |
0 | CAAAACCG | m6b | Disrupted | -0.044000 | no TS |
0.110000 |
|
hsa-miR-548ax |
aggtggttTTACTTCTgat |
0 | AGAAGUAA | m8a | Disrupted | -0.126000 | no TS |
0.400000 |
|
hsa-miR-548t-3p |
aggTGGTTTTacttctgat |
0 | AAAAACCA | m7b | (m7b->m6b) | -0.310000 | -0.201000 |
1.830000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr10:g.43128657G>A | COSN6970725 | 8031867 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3688-5p |
ctagTTGCCACcaaacaag |
2 |
AGUGGCAA | m7b | Created | -0.121000 | -0.313000 |
-0.020000 |
|
hsa-miR-4467 |
ctagttGCCGCCAaacaag |
3 |
UGGCGGCG | m7a | Disrupted | -0.296000 | no TS |
0.010000 |
|
hsa-miR-4730 |
ctagttgCCGCCAaacaag |
3 |
CUGGCGGA | m6b | Disrupted | -0.272000 | no TS |
6.320000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr10:g.43128731G>A | COSN8640079 | 1848_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-154-5p |
ggccctgATAACCTgtcct |
4 |
UAGGUUAU | m7b | Created | -0.292000 | -0.320000 | No effect | |
hsa-miR-374a-3p |
ggccCTGATAAcctgtcct |
0 | CUUAUCAG | m7b | Created | no TS | 0.013000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr10:g.43128845G>A | cosmic_v64_1760527 | Leukemia/T-ALL | |||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr10:g.43129858C>T | COSN8185424 | PCSI_0218_Pa_P_526 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3200-5p |
gctgttttTCAGATacact |
2 |
AAUCUGAG | m6b | Disrupted | -0.134000 | -0.078000 |
0.080000 |
|
hsa-miR-4799-5p |
gctgtttTTTAGATacact |
0 | AUCUAAAU | m7a | Created | NA | NA |
-7.367000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr10:g.43130168T>C | cosmic_v64_1760525 | Leukemia/T-ALL | |||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3688-3p |
ctggaaTTTCCATAcacgt |
0 | UAUGGAAA | m8a | Created | no TS | -0.187 |
-0.07 |
|
hsa-miR-5093 |
ctggaATTTCCatacacgt |
0 | AGGAAAUG | m6b | Created | no TS | -0.044 |
-0.02 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr10:g.43130235T>C | cosmic_v64_1760525 | Leukemia/T-ALL | ||||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-3660 |
atCTGTCAGTtattaaaat |
0 | ACUGACAG | m8a | (m8a->m7a) | -0.31 | -0.283 | No effect |
hsa-miR-4526 |
atCTGTCAGCtattaaaat |
0 | GCUGACAG | m8a | (m7a->m8a) | -0.319 | -0.292 | No effect |
hsa-miR-633 |
atctgtcagCTATTAaaat |
0 | CUAAUAGU | m6b | Created | no TS | -0.076 |
-0.84 |
hsa-miR-888-3p |
atcTGTCAGTtattaaaat |
8 |
GACUGACA | m7b | (m7b->m6b) | -0.266 | no TS |
0.01 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
43128657 | rs3026782 | G | G |
hsa-miR-4467 hsa-miR-4730 hsa-miR-6770-3p |
3 3 3 |
gttGCCGCCAaac gttgCCGCCAAac gttGCCGCCAAac |
Disrupted Disrupted Disrupted |
N N N |
-0.296 -0.272 -0.608 |
A |
hsa-miR-196a-3p hsa-miR-3688-5p |
5 4 |
GTTGCCAccaaac gTTGCCACcaaac |
Created Created |
N N |
-0.141 -0.192 |
|||
43129860 | rs76759170 | G | G |
hsa-miR-3200-5p hsa-miR-4766-5p |
10 7 |
tttTCAGATAcac tTTTCAGAtacac |
Disrupted Disrupted |
N N |
-0.056 -0.003 |
A |
hsa-miR-223-5p hsa-miR-510-3p |
14 7 |
ttttcaAATACAC tTTTCAAAtacac |
Created Created |
N N |
-0.122 0.041 |
|||
43129913 | rs117119161 | G | G |
hsa-miR-548aa hsa-miR-548ap-3p hsa-miR-548t-3p hsa-miR-570-3p |
6 8 7 22 |
ctttTGGTTTTca ctttTGGTTTTca ctttTGGTTTTca cttttgGTTTTCA |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.13 -0.13 -0.13 -0.026 |
C |
hsa-miR-548aj-5p hsa-miR-548e-5p hsa-miR-548f-5p hsa-miR-548g-5p hsa-miR-548p hsa-miR-548x-5p |
5 8 5 5 5 5 |
CTTTTGCttttca ctttTGCTTTTca CTTTTGCttttca CTTTTGCttttca cTTTTGCTtttca CTTTTGCttttca |
Created Created Created Created Created Created |
N N N N N N |
-0.159 -0.107 -0.159 -0.159 -0.082 -0.159 |
|||
43129923 | rs139925563 | A | A |
hsa-miR-3200-5p |
2 |
TCAGATAtgctta |
Disrupted |
N |
-0.078 |