SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001143993
Gene Symbol: RASSF7
Description: Homo sapiens Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 (RASSF7), transcript variant 2, mRNA.
Gene Location: chr11(+):560970-564025
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr11:g.563424T>T ICGC_48982 TCGA-DK-A1AC-01A-11D-A13W-08 BladderUrothelialCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3126-5p gagaggaGTCCCTCctggg
 0 UGAGGGAC m7b Disrupted -0.158 no TS No effect
hsa-miR-3928 gagaggaGTTCCTCCtggg
 0 GGAGGAAC m8a Created no TS -0.117 -0.29
hsa-miR-4779 gagaggagtCCCTCCTggg
 0 UAGGAGGG m7b (m7b->m6c) -0.205 -0.077 0.75
hsa-miR-766-5p gagaggagTTCCTCCTggg
 0 AGGAGGAA m8a Created no TS -0.103 -0.22

Mutation Mutation ID Sample Name Cancer Type
chr11:g.563554G>C ICGC_ssm_v3_86362 HCC2T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273g-3p tgtcctcccGCAGTGGccc
 0 ACCACUGC m7b (m7b->m6c) -0.327 -0.26 No effect
hsa-miR-1275 tgtccTCCCCCAgtggccc
 0 GUGGGGGA m7b Created no TS -0.143 -4.12
hsa-miR-4525 tgtccTCCCCCagtggccc
 0 GGGGGGAU m6b Created no TS -0.158 -3.85
hsa-miR-4665-5p tgtccTCCCCCAGtggccc
 0 CUGGGGGA m8a Created no TS -0.124 -0.97
hsa-miR-4723-5p tgtcCTCCCCCAgtggccc
 0 UGGGGGAG m8a Created -0.143 -0.504 -5.01
hsa-miR-4734 tgtcctCCCGCAGtggccc
 2
 GCUGCGGG m7b Disrupted -0.253 no TS 13.34
hsa-miR-5010-5p tgtccTCCCCCagtggccc
 0 AGGGGGAU m6b Created no TS -0.151 -6.57
hsa-miR-5698 tgtcCTCCCCCAgtggccc
 0 UGGGGGAG m8a Created -0.143 -0.504 -6.02
hsa-miR-625-5p tgtccTCCCCCagtggccc
 0 AGGGGGAA m6b Created no TS -0.134 -3.22
hsa-miR-637 tgtcctCCCCCAGTggccc
 0 ACUGGGGG m8a Created -0.117 -0.316 -2.66

Mutation Mutation ID Sample Name Cancer Type
chr11:g.563854A>G COSN1134824 HCC25T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3189-3p aggcCCCAAGGGccacgac
 0 CCCUUGGG m8a Created no TS -0.096000 -0.270000
hsa-miR-328 aggccccaAGGGCCAcgac
 0 CUGGCCCU m7b Created no TS -0.195000 -0.250000
hsa-miR-4260 agGCCCCAAGggccacgac
 4
 CUUGGGGC m8a (m7a->m8a) -0.333000 -0.130000 0.370000
hsa-miR-663b aggccccaaGGGCCACgac
 0 GGUGGCCC m7b (m6c->m7b) no TS -0.261000 -2.360000
hsa-miR-3189-3p aggcCCCAAGGGccacgac
 0 CCCUUGGG m8a Created no TS -0.096000 -0.270000
hsa-miR-328 aggccccaAGGGCCAcgac
 0 CUGGCCCU m7b Created no TS -0.195000 -0.250000
hsa-miR-4260 agGCCCCAAGggccacgac
 4
 CUUGGGGC m8a (m7a->m8a) -0.333000 -0.130000 0.370000
hsa-miR-663b aggccccaaGGGCCACgac
 0 GGUGGCCC m7b (m6c->m7b) no TS -0.261000 -2.360000
hsa-miR-3189-3p aggcCCCAAGGGccacgac
 0 CCCUUGGG m8a Created no TS -0.096 -0.27
hsa-miR-328 aggccccaAGGGCCAcgac
 0 CUGGCCCU m7b Created no TS -0.195 -0.25
hsa-miR-4260 agGCCCCAAGggccacgac
 4
 CUUGGGGC m8a (m7a->m8a) -0.333 -0.13 0.37
hsa-miR-663b aggccccaaGGGCCACgac
 0 GGUGGCCC m7b (m6c->m7b) no TS -0.261 -2.36

Mutation Mutation ID Sample Name Cancer Type
chr11:g.564013C>T COSN8684850 AOCS-159-1-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2682-5p taaACTGCCTGaagcagct
 0 CAGGCAGU m8a Created -0.109000 -0.374000 -3.440000
hsa-miR-3181 taaactGCCCGAagcagct
 0 AUCGGGCC m6b Disrupted -0.276000 no TS 0.050000
hsa-miR-34b-5p taaACTGCCTgaagcagct
 0 UAGGCAGU m7b (m6b->m7b) -0.100000 -0.375000 -2.230000
hsa-miR-3977 taaactgccTGAAGCAgct
 0 GUGCUUCA m7b (m6c->m7b) no TS -0.107000 -1.280000
hsa-miR-4269 taaacTGCCTGaagcagct
 0 GCAGGCAC m6b Created no TS -0.174000 No effect
hsa-miR-449c-5p taaACTGCCTgaagcagct
 0 UAGGCAGU m7b (m6b->m7b) -0.109000 -0.402000 -2.710000
hsa-miR-4514 taaaCTGCCTGaagcagct
 0 ACAGGCAG m7b Created -0.170000 -0.640000 -9.360000
hsa-miR-4692 taaaCTGCCTGAagcagct
 0 UCAGGCAG m8a Created -0.170000 -0.629000 -4.490000
hsa-miR-4742-5p taaacTGCCTGAagcagct
 1
 UCAGGCAA m7a Created -0.077000 -0.268000 -2.840000
hsa-miR-4750 taaactGCCCGAagcagct
 0 CUCGGGCG m6b Disrupted -0.309000 no TS 12.840000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
563502 rs201821227 C C hsa-miR-1915-3p
hsa-miR-4716-3p
hsa-miR-4723-5p
hsa-miR-5698
hsa-miR-6764-5p
hsa-miR-6794-5p
hsa-miR-6798-5p
hsa-miR-6870-5p
hsa-miR-7111-5p
2
2
2
2
2
2
2
2
2
 ctccCCCTGGGgc
cTCCCCCTggggc
CTCCCCCtggggc
CTCCCCCtggggc
ctccCCCTGGGgc
cTCCCCCTggggc
ctCCCCCTGgggc
CTCCCCCtggggc
CTCCCCCtggggc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
 -0.107
-0.118
-0.143
-0.143
-0.107
-0.136
-0.177
-0.171
-0.171
T hsa-miR-5699-5p
hsa-miR-6814-5p
2
2
 ctccccTTGGGGC
ctccCCTTGGGgc
 Created
Created
N
N
 -0.154
-0.064
563553 rs200464920 C C hsa-miR-4734
hsa-miR-7106-5p
2
2
 tcctCCCGCAGtg
TCCTCCCgcagtg
 Disrupted
Disrupted
N
N
 -0.253
-0.092
T hsa-miR-1205
hsa-miR-1286
hsa-miR-4418
hsa-miR-4459
hsa-miR-4722-5p
hsa-miR-509-3-5p
hsa-miR-509-5p
2
2
2
2
2
2
2
 tcctCCTGCAGtg
tccTCCTGCAgtg
tcctcCTGCAGTg
tCCTCCTGcagtg
tcCTCCTGCAgtg
tcctcCTGCAGTg
tcctcCTGCAGTg
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 -0.123
-0.107
-0.064
-0.162
-0.271
-0.054
-0.054
563554 rs202139378 G G hsa-miR-1273g-3p
hsa-miR-4734
2
2
 cctcccGCAGTGG
cctCCCGCAGtgg
 Disrupted
Disrupted
N
N
 -0.067
-0.253
A hsa-miR-1233-5p
hsa-miR-1273h-5p
hsa-miR-134-3p
hsa-miR-149-3p
hsa-miR-30b-3p
hsa-miR-3689a-3p
hsa-miR-3689b-3p
hsa-miR-3689c
hsa-miR-4318
hsa-miR-4648
hsa-miR-4654
hsa-miR-4728-5p
hsa-miR-4769-5p
hsa-miR-6778-5p
hsa-miR-6779-5p
hsa-miR-6780a-5p
hsa-miR-6785-5p
hsa-miR-6799-5p
hsa-miR-6883-5p
hsa-miR-7106-5p
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
 cCTCCCACAgtgg
CCTCCCAcagtgg
cctCCCACAGtgg
CCTCCCAcagtgg
CCTCCCAcagtgg
CCTCCCAcagtgg
CCTCCCAcagtgg
CCTCCCAcagtgg
cctcCCACAGTgg
ccTCCCACAgtgg
ccTCCCACAgtgg
CCTCCCAcagtgg
ccTCCCACAgtgg
cCTCCCACAgtgg
CCTCCCAcagtgg
CCTCCCAcagtgg
CCTCCCAcagtgg
CCTCCCAcagtgg
CCTCCCAcagtgg
CCTCCCAcagtgg
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
 -0.315
-0.206
-0.143
-0.109
-0.132
-0.141
-0.141
-0.141
-0.066
-0.114
-0.131
-0.105
-0.117
-0.326
-0.15
-0.188
-0.098
-0.118
-0.092
-0.184
563555 rs73399077 C C hsa-miR-1273g-3p
hsa-miR-4252
hsa-miR-4734
2
9
2
 ctcccGCAGTGGc
ctcccgCAGTGGC
ctCCCGCAGtggc
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.067
-0.085
-0.253
T hsa-miR-4681
2
 cTCCCGTAgtggc
 Created
N
 -0.205

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