| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
||||||||
| Home | Search | Help | Download | |||||
| RefSeq ID: | NM_001145370 |
|---|---|
| Gene Symbol: | PTPN3 |
| Description: | Homo sapiens protein tyrosine phosphatase, non-receptor type 3 (PTPN3), transcript variant 2, mRNA. |
| Gene Location: | chr9(-):112137973-112213664 |
| Browse Associations | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.109376763C>G | COSN15062754 | LP6005500-DNA_B01 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3974 |
ctgtttcacGACCTTatac |
1 |
AAAGGUCA | m6b | Created | -0.211000 | -0.268000 |
-0.010000 |
|
| hsa-miR-431-3p |
ctgtttcACGACCTtatac |
0 | CAGGUCGU | m7b | Created | no TS | -0.255000 |
-9.890000 |
|
| hsa-miR-4735-3p |
ctgtttcacCACCTTatac |
0 | AAAGGUGC | m6b | Disrupted | -0.053000 | no TS |
0.220000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.109377001A>G | COSN2305173 | RK041_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.109377570A>G | ICGC_81541886-2A78-11E2-96E7-04FD496BB9B8 | CPCG_0102_Pr_P_P1 | ProstateCancer(OICR,CA) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1273g-3p |
ggctggagtGCAGTGGcat |
0 | ACCACUGC | m7b | (m6b->m7b) | -0.076 | -0.183 |
-2.02 |
|
| hsa-miR-4793-3p |
ggctggAGTGCAGtggcat |
0 | UCUGCACU | m7b | Created | no TS | 0.084 |
0.05 |
|
| hsa-miR-508-5p |
ggCTGGAGTAcagtggcat |
0 | UACUCCAG | m8a | (m8a->m7b) | 0.058 | 0.083 |
2.47 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.109377869G>A | COSN4885597 | tumor_4189200 | [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1268a |
agttcctACGCCCactcag |
1 |
CGGGCGUG | m6b | Disrupted | -0.065000 | no TS |
1.750000 |
|
| hsa-miR-1268b |
agttcctACGCCCactcag |
1 |
CGGGCGUG | m6b | Disrupted | -0.065000 | no TS |
1.750000 |
|
| hsa-miR-4455 |
agttcctACACCCactcag |
2 |
AGGGUGUG | m6b | Created | -0.285000 | -0.257000 | No effect | |
| hsa-miR-585 |
agttccTACGCCCActcag |
1 |
UGGGCGUA | m8a | Disrupted | -0.132000 | no TS |
2.680000 |
|
| hsa-miR-609 |
agttcctACACCCactcag |
2 |
AGGGUGUU | m6b | Created | -0.130000 | -0.127000 |
-0.010000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.109377888C>T | COSN5695163 | RK085_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1913 |
gctaaGGGGCAGgggattc |
0 | UCUGCCCC | m7b | Disrupted | -0.251000 | -0.146000 |
0.020000 |
|
| hsa-miR-3162-3p |
gctaaggGGTAGGGgattc |
0 | UCCCUACC | m7b | Created | no TS | -0.031000 |
-5.120000 |
|
| hsa-miR-324-3p |
gctaaGGGGCAGgggattc |
0 | ACUGCCCC | m7b | Disrupted | -0.242000 | -0.137000 |
0.280000 |
|
| hsa-miR-4749-3p |
gctaAGGGGCaggggattc |
2 |
CGCCCCUC | m6b | Disrupted | -0.032000 | no TS |
1.480000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.109377920A>T | COSN6375391 | RK178_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-578 |
attgaaaACAAGAAaccac |
2 |
CUUCUUGU | m7b | Disrupted | 0.264000 | 0.137000 |
0.800000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.109379400C>T | COSN1084706 | TCGA-B5-A11E-01 | [endometrium][NS][carcinoma][endometrioid_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-338-5p |
aaaagATATTGTgtacata |
0 | AACAAUAU | m7b | Created | no TS | -0.052000 |
-2.600000 |
|
| hsa-miR-4731-3p |
aaaagataTTGTGTacata |
0 | CACACAAG | m6b | Created | 0.176000 | 0.113000 |
0.020000 |
|
| hsa-miR-338-5p |
aaaagATATTGTgtacata |
0 | AACAAUAU | m7b | Created | no TS | -0.052 |
-2.6 |
|
| hsa-miR-4731-3p |
aaaagataTTGTGTacata |
0 | CACACAAG | m6b | Created | 0.176 | 0.113 |
0.02 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr9:g.109379404A>T | COSN2305174 | RK041_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-5003-3p |
ataGAAAAGTtatcgtgta |
3 |
UACUUUUC | m7b | (m6c->m7b) | 0.060000 | -0.092000 |
0.220000 |
|
| hsa-miR-5003-3p |
ataGAAAAGTtatcgtgta |
0 | UACUUUUC | m7b | (m6c->m7b) | 0.06 | -0.092 |
0.22 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr9:g.109379511C>A | COSN1084705 | TCGA-AP-A059-01 | [endometrium][NS][carcinoma][endometrioid_carcinoma] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-3173-3p |
ggcatCCTCCTTgaaagag |
4 |
AAAGGAGG | m7b | Disrupted | -0.188000 | no TS | No effect |
| hsa-miR-3605-5p |
ggCATCCTCAttgaaagag |
5 |
UGAGGAUG | m8a | (m7b->m8a) | -0.267000 | -0.456000 | No effect |
| hsa-miR-4428 |
ggcatcCTCCTTGaaagag |
0 | CAAGGAGA | m7a | Disrupted | NA | NA | No effect |
| hsa-miR-561-5p |
ggcatccTCCTTGAaagag |
0 | AUCAAGGA | m7b | Disrupted | -0.265000 | no TS | No effect |
| hsa-miR-3173-3p |
ggcatCCTCCTTgaaagag |
0 | AAAGGAGG | m7b | Disrupted | -0.188 | no TS | No effect |
| hsa-miR-3605-5p |
ggCATCCTCAttgaaagag |
0 | UGAGGAUG | m8a | (m7b->m8a) | -0.267 | -0.456 | No effect |
| hsa-miR-4428 |
ggcatcCTCCTTGaaagag |
0 | CAAGGAGA | m7a | Disrupted | NA | NA | No effect |
| hsa-miR-561-5p |
ggcatccTCCTTGAaagag |
0 | AUCAAGGA | m7b | Disrupted | -0.265 | no TS | No effect |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 109376489 | rs113826491 | G | G |
hsa-miR-1913 hsa-miR-324-3p hsa-miR-4313 |
6 6 2 |
ggttagGGGGCAG ggttagGGGGCAG ggttAGGGGGCAg |
Disrupted Disrupted Disrupted |
N N N |
-0.146 -0.137 -0.44 |
| C |
hsa-miR-4707-3p |
4 |
ggttaGCGGGCAg |
Created |
N |
-0.21 |
|||
| 109377459 | rs191660985 | T | T |
hsa-miR-4731-3p hsa-miR-4801 |
0 |
cctggCTTGTGTg cctggCTTGTGTg |
Disrupted Disrupted |
N N |
0.164 0.146 |
| 109377869 | rs190049858 | G | G |
hsa-miR-1268a hsa-miR-1268b hsa-miR-585-3p |
1 1 1 |
tcctACGCCCAct tcctACGCCCAct tccTACGCCCAct |
Disrupted Disrupted Disrupted |
N N N |
-0.065 -0.065 -0.132 |
| A |
hsa-miR-4455 hsa-miR-609 hsa-miR-6748-5p hsa-miR-6772-5p hsa-miR-8065 |
1 1 1 1 1 |
tcctACACCCAct tcctACACCCAct tcctaCACCCACt tccTACACCCAct TCCTACAcccact |
Created Created Created Created Created |
N N N N N |
0.028 0.003 -0.062 0.013 -0.014 |
|||
| 109377894 | rs181698971 | A | A |
hsa-miR-22-3p |
2 |
GCAGCTAaggggc |
Disrupted |
N |
-0.005 |
| G |
hsa-miR-1207-3p hsa-miR-4749-3p hsa-miR-6787-3p |
2 2 4 |
gCAGCTGAggggc gcagctGAGGGGC gcAGCTGAGgggc |
Created Created Created |
N N N |
0.044 -0.085 0.099 |
|||
| 109379008 | rs114131793 | T | T |
hsa-miR-6758-5p hsa-miR-6856-5p |
2 2 |
aacaCCTCTCTgc aacaCCTCTCTgc |
Disrupted Disrupted |
N N |
-0.028 -0.055 |
| C |
hsa-miR-1914-3p hsa-miR-2467-3p hsa-miR-5194 hsa-miR-609 hsa-miR-6738-5p hsa-miR-6747-5p hsa-miR-6782-5p |
2 2 2 2 5 2 2 |
aacACCCCTCtgc aacaccCCTCTGC aacACCCCTCtgc AACACCCctctgc aacACCCCTCtgc aACACCCCtctgc aaCACCCCTctgc |
Created Created Created Created Created Created Created |
N N N N N N N |
-0.101 -0.065 -0.092 -0.073 -0.12 -0.128 -0.153 |
|||
| 109379514 | rs138931600 | C | C |
hsa-miR-3173-3p hsa-miR-3605-5p hsa-miR-6891-5p hsa-miR-6894-5p |
4 5 4 5 |
ggcatCCTCCTTg ggCATCCTCcttg ggcatCCTCCTTg ggcATCCTCCttg |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.188 -0.152 -0.197 -0.173 |
| T |
hsa-miR-6830-5p |
2 |
ggcatcTTCCTTG |
Created |
N |
-0.161 |