SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_000963
Gene Symbol:	PTGS2
Description:	Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2), mRNA.
Gene Location:	chr1(-):186640943-186649559
Browse Associations
Browse Pathways

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.186671994A>T			9_66242		CRC-7-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.186672142T>A			COSN14468694		8057490		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4282	tgaaaaAAATTTTcttttg	2	UAAAAUUU	m7b	Disrupted	0.902000	0.909000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.186672424T>A			COSN6012380		RK211_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-335-3p	atttgTGAAAAAattttta	7	UUUUUCAU	m7a	Created	-0.023000	-0.008000	No effect
hsa-miR-5096	atttGTGAAAaaattttta	3	GUUUCACC	m6b	Created	0.024000	-0.021000	-0.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.186672844T>G			9_474		CRC-2-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3143	gcagagAATGTTATttata	6	AUAACAUU	m8a	Created	no TS	0.041	-0.02
hsa-miR-3163	gcagagaATTTTATttata	9	UAUAAAAU	m7b	Disrupted	0.413	0.314	No effect
hsa-miR-4282	gcagagAATTTTAtttata	6	UAAAAUUU	m7a	Disrupted	0.902	0.748	0.01
hsa-miR-543	gcagaGAATGTTatttata	5	AAACAUUC	m7b	Created	-0.247	-0.288	-0.07
hsa-miR-5571-5p	gcaGAGAATTttatttata	7	CAAUUCUC	m7b	(m7b->m6c)	-0.032	no TS	0.29

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.186672911T>C			0_37				Small cell lung cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4474-5p	ttaagaAGACTAAaagaga	0	UUAGUCUC	m7a	Created	no TS	-0.028	-0.04

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.186674009T>A			COSN6012381		RK210_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4668-3p	tgctgaaaGATTTTacact	0	GAAAAUCC	m6b	Created	no TS	0.035000	-0.470000
hsa-miR-548ac	tgctgaaaGTTTTTacact	0	CAAAAACC	m6b	Disrupted	0.081000	0.023000	5.320000
hsa-miR-548ae	tgctgaaAGTTTTTacact	0	CAAAAACU	m7b	Disrupted	-0.103000	-0.083000	0.470000
hsa-miR-548ah-3p	tgctgaaAGTTTTTacact	0	CAAAAACU	m7b	Disrupted	-0.124000	-0.083000	4.210000
hsa-miR-548aj-3p	tgctgaaAGTTTTTAcact	0	UAAAAACU	m8a	Disrupted	-0.103000	-0.083000	0.580000
hsa-miR-548am-3p	tgctgaaAGTTTTTacact	0	CAAAAACU	m7b	Disrupted	-0.114000	-0.083000	3.390000
hsa-miR-548aq-3p	tgctgaaAGTTTTTacact	0	CAAAAACU	m7b	Disrupted	-0.124000	-0.083000	1.750000
hsa-miR-548d-3p	tgctgaaaGTTTTTacact	0	CAAAAACC	m6b	Disrupted	0.070000	0.012000	0.380000
hsa-miR-548e	tgctgaaAGTTTTTacact	0	AAAAACUG	m7a	Disrupted	-0.041000	-0.041000	No effect
hsa-miR-548f	tgctgaaAGTTTTTacact	0	AAAAACUG	m7a	Disrupted	-0.041000	-0.041000	No effect
hsa-miR-548h-3p	tgctgaaaGTTTTTacact	0	CAAAAACC	m6b	Disrupted	0.081000	0.023000	4.140000
hsa-miR-548x-3p	tgctgaaAGTTTTTAcact	0	UAAAAACU	m8a	Disrupted	-0.103000	-0.083000	0.580000
hsa-miR-548z	tgctgaaaGTTTTTacact	0	CAAAAACC	m6b	Disrupted	0.081000	0.023000	4.140000
hsa-miR-5582-3p	tgctgaAAGTTTTtacact	5	UAAAACUU	m7b	Disrupted	0.257000	0.284000	0.440000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.186674153G>A			COSN1417918		RK099_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1305	ttaagtTTGAAAAacagtt	3	UUUUCAAC	m7a	Created	-0.031000	-0.034000	-0.030000
hsa-miR-607	ttaagTTTGAAaaacagtt	4	GUUCAAAU	m6b	Created	-0.068000	-0.073000	No effect
hsa-miR-1305	ttaagtTTGAAAAacagtt	0	UUUUCAAC	m7a	Created	-0.031	-0.034	-0.03
hsa-miR-607	ttaagTTTGAAaaacagtt	0	GUUCAAAU	m6b	Created	-0.068	-0.073	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.186674267T>C			COSN6012382		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4803	ctccTTATGTTActtaaca	4	UAACAUAA	m8a	Disrupted	-0.148000	no TS	No effect
hsa-miR-562	ctccttatGCTACTTaaca	0	AAAGUAGC	m7b	Created	no TS	-0.413000	-0.050000
hsa-miR-802	ctccttaTGTTACTtaaca	8	CAGUAACA	m7b	Disrupted	-0.220000	no TS	No effect

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
186671972	rs185983564	T	T	hsa-miR-2053 hsa-miR-569	3 3	ttgttATTAACAt ttgttATTAACAt	Disrupted Disrupted	N N	-0.138 -0.055
186671972	rs185983564	T	C	hsa-miR-802	4	tTGTTACTAacat	Created	N	-0.341
186672066	rs4648303	T
186672066	rs4648303	T	T	hsa-miR-3163 hsa-miR-4803	0	ATTTTATgtttag attTTATGTTtag	Disrupted Disrupted	N N	-0.002 -0.144
186672141	rs689467	T	T	hsa-miR-4282	1	aaAAATTTTcttt	Disrupted	N	-0.007
186672141	rs689467	T	G	hsa-miR-153-5p hsa-miR-3133	1 16	AAAAATGttcttt aaaaatGTTCTTT	Created Created	N N	-0.054 -0.11
186672607	rs200177856	A	A	hsa-let-7f-2-3p hsa-miR-1185-1-3p hsa-miR-1185-2-3p hsa-miR-1277-5p	11 11 11 9	CTGTATAttactt CTGTATAttactt CTGTATAttactt ctgTATATTActt	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.105 -0.078 -0.096 0.089
186672607	rs200177856	A	G	hsa-miR-4803 hsa-miR-802	9 7	ctgTATGTTActt ctgtaTGTTACTt	Created Created	N N	0.029 -0.149
186672745	rs200069207	C	C	hsa-miR-1292-5p	0	aagttaCGTTCCC	Disrupted	N	-0.184
186672745	rs200069207	C	T	hsa-miR-4803	1	aagTTATGTTccc	Created	N	0.11
186672755	rs182127940	G	G	hsa-miR-145-5p hsa-miR-3180-5p hsa-miR-5195-3p	2 2 2	tgACTGGAAaaag tgaCTGGAAAaag tgACTGGAAaaag	Disrupted Disrupted Disrupted	N N N	-0.049 -0.002 -0.038
186672755	rs182127940	G	A	hsa-miR-30a-3p hsa-miR-30d-3p hsa-miR-30e-3p hsa-miR-335-3p hsa-miR-4704-3p	2 2 2 2 2	tgACTGAAAAaag tgACTGAAAAaag tgACTGAAAAaag tgacTGAAAAAag TGACTGAaaaaag	Created Created Created Created Created	N N N N N	0.064 0.054 0.043 0.109 -0.093
186672848	rs13306032	G	G	hsa-miR-3191-5p hsa-miR-5571-5p hsa-miR-6728-3p	4 2 4	agCAGAGAAtttt agcaGAGAATTtt AGCAGAGAatttt	Disrupted Disrupted Disrupted	N N N	-0.061 -0.033 -0.242
186672848	rs13306032	G	T	hsa-miR-4686	4	AGCAGATAatttt	Created	N	-0.258
186672964	rs200409468	A	A	hsa-miR-518a-5p hsa-miR-527 hsa-miR-548aw hsa-miR-5582-3p	5 5 5 9	TTTGCAAgttttc TTTGCAAgttttc TTTGCAAgttttc tttgcAAGTTTTc	Disrupted Disrupted Disrupted Disrupted	N N N N	0.065 0.065 0.002 0.161
186672964	rs200409468	A	C	hsa-miR-19a-3p hsa-miR-19b-3p hsa-miR-424-3p	5 5 9	TTTGCACgttttc TTTGCACgttttc tttgcACGTTTTc	Created Created Created	N N N	-0.026 -0.026 0.065
186673415	rs201467945	A
186673415	rs201467945	A	T	hsa-miR-4282	3	cAAATTTTtgttc	Created	N	0.158
186673690	rs3134590	A
186673690	rs3134590	A	T	hsa-miR-1305	3	atcaGTTGAAAtt	Created	N	-0.084
186674143	rs139462473	T	T	hsa-miR-548a-3p hsa-miR-548ac hsa-miR-548ae hsa-miR-548ah-3p hsa-miR-548aj-3p hsa-miR-548am-3p hsa-miR-548aq-3p hsa-miR-548ar-3p hsa-miR-548az-3p hsa-miR-548d-3p hsa-miR-548e-3p hsa-miR-548f-3p hsa-miR-548g-3p hsa-miR-548h-3p hsa-miR-548j-3p hsa-miR-548x-3p hsa-miR-548z	5 1 1 1 1 1 1 5 5 1 5 5 5 1 1 1 1	aCAGTTTTtattc acaGTTTTTAttc acAGTTTTTAttc acAGTTTTTAttc acAGTTTTTAttc acAGTTTTTAttc acAGTTTTTAttc aCAGTTTTtattc aCAGTTTTtattc acaGTTTTTAttc aCAGTTTTtattc aCAGTTTTtattc ACAGTTTttattc acaGTTTTTAttc acAGTTTTTAttc acAGTTTTTAttc acaGTTTTTAttc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N N N N N	-0.161 0.023 -0.083 -0.083 -0.083 -0.083 -0.083 -0.133 -0.161 0.012 -0.161 -0.161 -0.209 0.023 -0.083 -0.083 0.023
186674143	rs139462473	T
186674268	rs200232733	G	G	hsa-miR-4803 hsa-miR-802	4 8	ccTTATGTTActt ccttaTGTTACTt	Disrupted Disrupted	N N	-0.148 -0.22
186674268	rs200232733	G	A	hsa-miR-1277-5p	4	cctTATATTActt	Created	N	0.018

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser