SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_005672
Gene Symbol:	PSCA
Description:	Homo sapiens prostate stem cell antigen (PSCA), transcript variant 1, mRNA.
Gene Location:	chr8(+):143761873-143764145
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.142682142G>T			COSN8518546		14_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-296-5p	gctctggGGGGCCCcgctg	0	AGGGCCCC	m7b	Disrupted	0.000000	no TS	No effect
hsa-miR-361-3p	gctCTGGGGGgccccgctg	0	UCCCCCAG	m7b	(m7b->m6b)	0.000000	no TS	No effect
hsa-miR-5090	gctctggggTGCCCCGctg	0	CCGGGGCA	m7b	(m6c->m7b)	no TS	0.000000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.142682175C>T			COSN5233734		SS6003308		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4649-3p	tgtggtGCCTCAGgcctct	2	UCUGAGGC	m7b	Created	-0.189000	-0.312000	-0.020000
hsa-miR-486-3p	tgtggTGCCCCaggcctct	2	CGGGGCAG	m6b	Disrupted	-0.135000	no TS	No effect
hsa-miR-544b	tgtggtgCCTCAGGcctct	5	ACCUGAGG	m7b	Created	-0.039000	-0.150000	-0.030000
hsa-miR-593-5p	tgTGGTGCCTcaggcctct	2	AGGCACCA	m8a	(m7a->m8a)	-0.153000	-0.181000	-0.040000
hsa-miR-661	tgtggtgcCCCAGGCctct	1	UGCCUGGG	m7b	Disrupted	-0.141000	no TS	0.060000
hsa-miR-4649-3p	tgtggtGCCTCAGgcctct	2	UCUGAGGC	m7b	Created	-0.189000	-0.312000	-0.020000
hsa-miR-486-3p	tgtggTGCCCCaggcctct	2	CGGGGCAG	m6b	Disrupted	-0.135000	no TS	No effect
hsa-miR-544b	tgtggtgCCTCAGGcctct	5	ACCUGAGG	m7b	Created	-0.039000	-0.150000	-0.030000
hsa-miR-593-5p	tgTGGTGCCTcaggcctct	2	AGGCACCA	m8a	(m7a->m8a)	-0.153000	-0.181000	-0.040000
hsa-miR-661	tgtggtgcCCCAGGCctct	1	UGCCUGGG	m7b	Disrupted	-0.141000	no TS	0.060000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.142682347G>C			COSN7668129		PCSI_0307_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-105-3p	attgacacACATCCGcctg	0	ACGGAUGU	m7b	Created	no TS	-0.183000	-3.880000
hsa-miR-4764-5p	attgacaCACATCCgcctg	1	UGGAUGUG	m7b	Created	-0.169000	-0.299000	-3.540000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
142682529	rs144614802	C	C	hsa-miR-1200 hsa-miR-1909-5p hsa-miR-4324 hsa-miR-544b hsa-miR-660-3p	5 5 5 5 5	ggcaCTCAGGAgg GGCACTCAggagg ggcaCTCAGGAgg ggcaCTCAGGAgg ggcactCAGGAGG	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.089 -0.432 -0.051 -0.039 -0.119
			T	hsa-miR-302a-3p hsa-miR-302b-3p hsa-miR-302c-3p hsa-miR-302d-3p hsa-miR-302e hsa-miR-372-3p hsa-miR-373-3p hsa-miR-519a-3p hsa-miR-519b-3p hsa-miR-519c-3p hsa-miR-520a-3p hsa-miR-520b hsa-miR-520c-3p hsa-miR-520d-3p hsa-miR-520e	5 5 5 5 5 5 5 5 5 5 5 5 5 5 5	gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg gGCACTTAggagg	Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N N N N N	-0.036 -0.036 -0.036 -0.036 -0.046 -0.029 -0.036 -0.05 -0.05 -0.046 -0.036 -0.033 -0.033 -0.036 -0.033
142682540	rs1045574	G	G	hsa-miR-4655-5p	1	gggCCCGGTAaag	Disrupted	N	-0.246
			A	hsa-miR-296-5p hsa-miR-6724-5p hsa-miR-6773-5p	1 1 1	GGGCCCAgtaaag GGGCCCAgtaaag GGGCCCAgtaaag	Created Created Created	N N N	-0.198 -0.26 -0.288
142682683	rs1045605	C	C	hsa-miR-2467-5p hsa-miR-3188 hsa-miR-3975 hsa-miR-4649-3p hsa-miR-4663 hsa-miR-485-5p hsa-miR-6884-5p hsa-miR-7160-5p hsa-miR-8077	2 2 2 2 2 2 2 2 2	cAGCCTCAgcaca cAGCCTCAgcaca cAGCCTCAgcaca caGCCTCAGcaca cagcCTCAGCAca CAGCCTCAgcaca CAGCCTCAgcaca cagCCTCAGCAca cagcCTCAGCAca	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	-0.126 -0.131 -0.13 -0.189 -0.116 -0.283 -0.304 -0.312 -0.123
			G	hsa-miR-3155a hsa-miR-3155b hsa-miR-3934-3p hsa-miR-484	2 2 2 2	cAGCCTGAgcaca cAGCCTGAgcaca cagCCTGAGCAca cAGCCTGAgcaca	Created Created Created Created	N N N N	-0.122 -0.122 -0.357 -0.108

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