SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_004248
Gene Symbol:	PRLHR
Description:	Homo sapiens prolactin releasing hormone receptor (PRLHR), mRNA.
Gene Location:	chr10(-):120352915-120355160
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.118593715G>A			COSN6058485		RK121_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4470	agattttcaGTTTGCCttt	3	UGGCAAAC	m7b	(m7b->m6b)	-0.225000	no TS	-0.150000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.118593997C>A			COSN8639133		381_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4446-3p	cagccCAGCCCTcttgtcc	5	CAGGGCUG	m7b	Disrupted	-0.156000	no TS	1.360000
hsa-miR-4492	cagcCCAGCCCtcttgtcc	5	GGGGCUGG	m7b	Disrupted	-0.630000	-0.472000	5.870000
hsa-miR-4498	cagcCCAGCCCtcttgtcc	5	UGGGCUGG	m7b	Disrupted	-0.627000	-0.451000	2.990000
hsa-miR-4505	cagCCCAGCCctcttgtcc	6	AGGCUGGG	m7b	(m7b->m6c)	-0.204000	no TS	3.050000
hsa-miR-4721	cagcccAGCCCTCttgtcc	5	UGAGGGCU	m7b	Disrupted	-0.181000	no TS	4.540000
hsa-miR-5001-5p	cagcCCAGCCCTcttgtcc	5	AGGGCUGG	m8a	Disrupted	-0.619000	-0.461000	1.420000
hsa-miR-512-3p	cagccCAGCACTcttgtcc	0	AAGUGCUG	m7b	Created	no TS	-0.122000	-0.110000
hsa-miR-762	cagcCCAGCCCtcttgtcc	5	GGGGCUGG	m7b	Disrupted	-0.637000	-0.461000	4.140000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
118593714	rs187377414	T	T	hsa-miR-4470	4	tttcaGTTTGCCt	Disrupted	N	-0.225

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