SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_014906
Gene Symbol: PPM1E
Description: Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1E (PPM1E), mRNA.
Gene Location: chr17(+):56833231-57062534
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr17:g.58981260T>C COSN15480184 AOCS-139-19-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5582-5p tgtgaTGTGCCTcgacacc
 14
 UAGGCACA m7b Created -0.378000 -0.534000 No effect
hsa-miR-642a-3p tgtgATGTGTCTcgacacc
 0 AGACACAU m8a Disrupted -0.101000 no TS 2.610000
hsa-miR-642b-3p tgtgATGTGTCTcgacacc
 0 AGACACAU m8a Disrupted -0.120000 no TS 5.210000
hsa-miR-5582-5p tgtgaTGTGCCTcgacacc
 14
 UAGGCACA m7b Created -0.378000 -0.534000 No effect
hsa-miR-642a-3p tgtgATGTGTCTcgacacc
 0 AGACACAU m8a Disrupted -0.101000 no TS 2.610000
hsa-miR-642b-3p tgtgATGTGTCTcgacacc
 0 AGACACAU m8a Disrupted -0.120000 no TS 5.210000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.58981581G>T COSN14967883 LP6005409-DNA_G03 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1255b-2-3p acaatgaAAGTGGTaaatc
 11
 AACCACUU m7b Disrupted -0.397000 -0.090000 2.080000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.58982002T>A COSN9671637 C0058T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-302a-5p aagtgaTTTAAGagaatga
 0 ACUUAAAC m6b Created no TS 0.077000 No effect
hsa-miR-4668-3p aagtGATTTTagagaatga
 3
 GAAAAUCC m6b Disrupted 0.182000 0.101000 No effect
hsa-miR-4684-5p aagtgatttTAGAGAatga
 12
 CUCUCUAC m6b Disrupted -0.075000 -0.039000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.58982830C>G COSN8840799 AOCS-150-3-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3151 gaggctttGCCCCACacat
 2
 GGUGGGGC m7b Disrupted -0.166000 no TS 1.960000
hsa-miR-3926 gaggcTTTGGCCcacacat
 0 UGGCCAAA m7b Created no TS 0.065000 -0.060000
hsa-miR-4265 gaggctttgGCCCACAcat
 0 CUGUGGGC m7b (m6c->m7b) no TS -0.048000 -0.200000
hsa-miR-4296 gaggctttgGCCCACAcat
 0 AUGUGGGC m7b (m6c->m7b) no TS -0.057000 -1.270000
hsa-miR-4322 gaggctttgGCCCACAcat
 0 CUGUGGGC m7b (m6c->m7b) no TS -0.029000 0.130000
hsa-miR-4417 gaggctttgGCCCACacat
 0 GGUGGGCU m6b Created no TS -0.055000 -0.080000
hsa-miR-4447 gaggctttgCCCCACacat
 2
 GGUGGGGG m6b Disrupted -0.013000 no TS -0.040000
hsa-miR-4472 gaggctttgCCCCACacat
 2
 GGUGGGGG m6b Disrupted -0.013000 no TS No effect
hsa-miR-4726-5p gaggcttTGGCCCacacat
 0 AGGGCCAG m6b Created no TS -0.047000 -4.690000
hsa-miR-486-3p gaggcttTGCCCCacacat
 2
 CGGGGCAG m6b Disrupted -0.163000 -0.137000 0.880000
hsa-miR-491-5p gaggctttgCCCCACacat
 2
 AGUGGGGA m6b Disrupted -0.029000 no TS 0.200000

Mutation Mutation ID Sample Name Cancer Type
chr17:g.58982991->A ICGC_ssm_v3_128049 HCC63T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2681-5p tagcgaaGTAAAAaaaaaa
 0 GUUUUACC m6b Disrupted 0.149000 0.146000 -0.190000
hsa-miR-3682-5p tagcGAAGTAaaaaaaaaa
 0 CUACUUCU m6b Disrupted -0.126000 -0.127000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.58983329G>T COSN8840800 AOCS-083-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-224-3p gtACCATTTTtaaggtaaa
 1
 AAAAUGGU m8a (m7a->m8a) -0.092000 -0.119000 0.010000
hsa-miR-520d-5p gtaccaTTTGTAaggtaaa
 17
 CUACAAAG m6b Disrupted 0.161000 no TS No effect
hsa-miR-522-3p gtACCATTTTtaaggtaaa
 1
 AAAAUGGU m8a (m7a->m8a) -0.098000 -0.125000 No effect
hsa-miR-524-5p gtaccaTTTGTAaggtaaa
 17
 CUACAAAG m6b Disrupted 0.161000 no TS No effect
hsa-miR-548c-3p gtaccATTTTTaaggtaaa
 5
 CAAAAAUC m6b Created 0.575000 0.809000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr17:g.58984505G>C COSN6548839 ICGC_MB92 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3651 cctaagcaaGGCTATaaaa
 2
 CAUAGCCC m6b Disrupted -0.241000 -0.112000 0.190000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
58981761 rs80294151 A A hsa-miR-3606-3p
hsa-miR-3692-3p
hsa-miR-4282
hsa-miR-513a-3p
hsa-miR-513c-3p
hsa-miR-548c-3p
0 gtgGAAATTTtta
GTGGAAAttttta
gtggAAATTTTta
gtgGAAATTTtta
gtgGAAATTTtta
gtggaaATTTTTA
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 0.05
-0.091
0.108
0.059
0.059
0.151
58983722 rs7502088 G G hsa-miR-197-3p
hsa-miR-5096
11
12
 gGTGGTGAAagtt
ggtGGTGAAAgtt
 Disrupted
Disrupted
N
N
 -0.042
0.067
A hsa-miR-2681-5p
12
 ggtGGTAAAAgtt
 Created
N
 0.062
58984791 rs190487220 T T hsa-miR-3121-3p
4
 gaagaCTATTTAt
 Disrupted
N
 -0.017
C hsa-miR-224-3p
hsa-miR-4694-3p
hsa-miR-522-3p
4
4
4
 gaagACCATTTAt
gaagaCCATTTAt
gaagACCATTTAt
 Created
Created
Created
N
N
N
 -0.199
-0.052
-0.22

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