SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000446
Gene Symbol: PON1
Description: Homo sapiens paraoxonase 1 (PON1), mRNA.
Gene Location: chr7(-):94927668-94953884
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr7:g.95298511A>C COSN8048235 8057501 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1289 cacccagGGACTCCAgttc
 0 UGGAGUCC m8a Disrupted -0.384000 no TS 3.370000
hsa-miR-1291 caccCAGGGCCtccagttc
 0 UGGCCCUG m7b Created no TS -0.209000 -13.360000
hsa-miR-2114-5p cacccAGGGACTccagttc
 0 UAGUCCCU m7b Disrupted -0.154000 no TS 2.470000
hsa-miR-3198 cacccaggGACTCCAgttc
 0 GUGGAGUC m7b Disrupted -0.169000 no TS 4.360000
hsa-miR-3612 cacccaggGCCTCCagttc
 0 AGGAGGCA m6b Created no TS -0.168000 -13.230000
hsa-miR-4294 cacccaggGACTCCagttc
 0 GGGAGUCU m6b Disrupted -0.139000 no TS 5.540000
hsa-miR-4309 cacccaggGACTCCAGttc
 0 CUGGAGUC m8a Disrupted -0.132000 no TS 0.010000
hsa-miR-4443 cacccaggGCCTCCAgttc
 0 UUGGAGGC m7b Created no TS -0.207000 -9.810000
hsa-miR-5008-5p cacccaGGGCCTCcagttc
 0 UGAGGCCC m7b Created no TS -0.268000 -7.070000
hsa-miR-650 cacccaggGCCTCCagttc
 0 AGGAGGCA m6b Created no TS -0.151000 -0.060000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.95298543C>T COSN7660113 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4643 gttagctCATGTGTCttta
 0 GACACAUG m8a Created -0.286000 -0.428000 -0.020000
hsa-miR-556-5p gttAGCTCATgtgtcttta
 0 GAUGAGCU m7b (m6c->m7b) no TS -0.165000 8.450000
hsa-miR-642a-3p gttagctcATGTGTCTtta
 0 AGACACAU m8a Created no TS -0.129000 No effect
hsa-miR-642b-3p gttagctcATGTGTCTtta
 0 AGACACAU m8a Created no TS -0.129000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.95298631C>T COSN15471094 AOCS-171-1-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2909 gtacttaCCCTAAaacatg
 6
 GUUAGGGC m6b Disrupted -0.269000 -0.135000 3.230000
hsa-miR-4477b gtacttaCCTTAAaacatg
 0 AUUAAGGA m6b Created no TS -0.053000 -1.840000
hsa-miR-548ag gtacTTACCTTaaaacatg
 0 AAAGGUAA m7b Created no TS -0.221000 -3.320000
hsa-miR-548ai gtacTTACCTTaaaacatg
 0 AAAGGUAA m7b Created no TS -0.231000 -4.500000
hsa-miR-555 gtaCTTACCCTaaaacatg
 0 AGGGUAAG m8a Disrupted -0.248000 no TS 0.700000
hsa-miR-570-5p gtacTTACCTTaaaacatg
 0 AAAGGUAA m7b Created no TS -0.231000 -4.500000
hsa-miR-2909 gtacttaCCCTAAaacatg
 6
 GUUAGGGC m6b Disrupted -0.269000 -0.135000 3.230000
hsa-miR-4477b gtacttaCCTTAAaacatg
 0 AUUAAGGA m6b Created no TS -0.053000 -1.840000
hsa-miR-548ag gtacTTACCTTaaaacatg
 0 AAAGGUAA m7b Created no TS -0.221000 -3.320000
hsa-miR-548ai gtacTTACCTTaaaacatg
 0 AAAGGUAA m7b Created no TS -0.231000 -4.500000
hsa-miR-555 gtaCTTACCCTaaaacatg
 0 AGGGUAAG m8a Disrupted -0.248000 no TS 0.700000
hsa-miR-570-5p gtacTTACCTTaaaacatg
 0 AAAGGUAA m7b Created no TS -0.231000 -4.500000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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