SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_006502
Gene Symbol: POLH
Description: Homo sapiens polymerase (DNA directed), eta (POLH), mRNA.
Gene Location: chr6(+):43543877-43588260
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr6:g.43615310G>C ICGC_7A5E2648-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1256 acctgtAATGCCagcactt
 2
 AGGCAUUG m6b Disrupted -0.079 -0.072 0.06
hsa-miR-204-3p acctgtaaTCCCAGCactt
 0 GCUGGGAA m7a Created NA NA No effect
hsa-miR-4720-5p acctgtaATGCCAGcactt
 2
 CCUGGCAU m7b Disrupted -0.139 no TS 0.07
hsa-miR-4799-3p acctgtaATGCCAGcactt
 2
 ACUGGCAU m7b Disrupted -0.092 no TS 1.35
hsa-miR-5089 acctgtAATCCCAgcactt
 0 GUGGGAUU m7b Created 0.614 0.583 -0.04
hsa-miR-5588-5p acctgtaATGCCAGcactt
 2
 ACUGGCAU m7b Disrupted -0.092 no TS 0.57
hsa-miR-5589-5p acctgtaatCCCAGCactt
 0 GGCUGGGU m6b Created -0.03 -0.118 -0.08


Mutation Mutation ID Sample Name Cancer Type
chr6:g.43615456A>G ICGC_A024ECF4-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr6:g.43615517C>T ICGC_7A5E2B16-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-143-5p tcgcgccACTGCACtccag
 0 GGUGCAGU m7b Created 0.36 0.365 -0.04
hsa-miR-4746-3p tcgcgcCACCGCactccag
 1
 AGCGGUGC m6b Disrupted -0.197 -0.095 0.25
hsa-miR-5693 tcgcGCCACTGCactccag
 0 GCAGUGGC m8a Created 0.109 0.116 No effect


Mutation Mutation ID Sample Name Cancer Type
chr6:g.43615650A>T COSN7883531 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr6:g.43616817T>C COSN5630465 RK120_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273f ccattggcCCATCTCttgc
 2
 GGAGAUGG m7b Created -0.611000 -0.567000 No effect
hsa-miR-1295b-3p ccattGGCCTATctcttgc
 1
 AAUAGGCC m7b Disrupted -0.060000 0.023000 1.840000
hsa-miR-15a-3p ccatTGGCCTatctcttgc
 2
 CAGGCCAU m6b Disrupted -0.055000 no TS 0.020000
hsa-miR-4726-5p ccatTGGCCCatctcttgc
 1
 AGGGCCAG m6b Created -0.031000 -0.094000 -0.820000
hsa-miR-5704 ccatTGGCCTAtctcttgc
 1
 UUAGGCCA m7b Disrupted -0.132000 -0.051000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.43618187C>T COSN7883532 8031544 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3120-3p atggagtcTTGCTGTGtag
 0 CACAGCAA m8a Created no TS 0.099000 -1.610000
hsa-miR-4432 atgGAGTCTTgctgtgtag
 0 AAAGACUC m7b (m6b->m7b) no TS 0.075000 No effect
hsa-miR-451b atggagTCTTGCTgtgtag
 0 UAGCAAGA m7b Created no TS 0.044000 No effect
hsa-miR-4696 atggaGTCTTGCtgtgtag
 0 UGCAAGAC m7b Created no TS -0.010000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.43618994T>G COSN14812609 8051728 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1224-3p ttgaagAGGTGGGGaagat
 2
 CCCCACCU m8a Disrupted -0.050000 -0.013000 3.840000
hsa-miR-2355-5p ttgaagaggTGGGGAagat
 1
 AUCCCCAG m6b Disrupted -0.035000 -0.021000 0.080000
hsa-miR-3679-3p ttgaagaggGGGGGAAGat
 1
 CUUCCCCC m8a (m7b->m8a) -0.008000 -0.054000 -7.600000
hsa-miR-4286 ttgaagagGTGGGGaagat
 2
 ACCCCACU m6b Disrupted -0.060000 no TS 0.560000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.43620007A>G COSN6321179 RK214_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
43615094 rs55704248 C C hsa-miR-1273f
hsa-miR-8069
1
1
 caaaaCCATCTCt
caaAACCATCtct
 Disrupted
Disrupted
N
N
 -0.213
-0.148
43615749 rs7753247 C C hsa-miR-4746-3p
hsa-miR-4792
1
1
 gctCACCGCAacc
GCTCACCgcaacc
 Disrupted
Disrupted
N
N
 -0.095
-0.058
T hsa-miR-6499-3p
hsa-miR-6516-5p
1
1
 gctCACTGCAacc
gctcACTGCAAcc
 Created
Created
N
N
 0.029
0.095
43616335 rs187426826 T T hsa-miR-1295b-3p
2
 catGCCTATAatc
 Disrupted
N
 0.001
C hsa-miR-3115
hsa-miR-3945
hsa-miR-4253
hsa-miR-6862-5p
2
2
2
2
 catgCCCATAAtc
cATGCCCAtaatc
CATGCCCAtaatc
CATGCCCAtaatc
 Created
Created
Created
Created
N
N
N
N
 0.011
-0.033
-0.087
-0.098
43617070 rs111841811 A A hsa-miR-5089-5p
hsa-miR-619-5p
hsa-miR-6506-5p
2
2
2
 cgtgtAATCCCAg
cgtgtaATCCCAG
cgtgtaATCCCAG
 Disrupted
Disrupted
Disrupted
N
N
N
 0.118
0.022
0.041
T hsa-miR-204-3p
hsa-miR-4646-5p
hsa-miR-6716-5p
2
2
2
 cgtgtaTTCCCAG
cgtgtaTTCCCAG
cgtgtATTCCCAg
 Created
Created
Created
N
N
N
 0.056
0.038
0.09
43617458 rs187347958 T T hsa-miR-1273f
hsa-miR-3674
hsa-miR-4732-5p
hsa-miR-6832-5p
1
1
1
1
 cCCATCTCtacaa
cccatcTCTACAA
cccatCTCTACAa
cccaTCTCTACAa
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.002
0.033
-0.001
0.001
C hsa-miR-135b-3p
hsa-miR-6757-5p
1
1
 cccatCCCTACAA
ccCATCCCTAcaa
 Created
Created
N
N
 -0.124
-0.022
43617681 rs200723098 G G hsa-miR-106a-5p
hsa-miR-106b-5p
hsa-miR-17-5p
hsa-miR-20a-5p
hsa-miR-20b-5p
hsa-miR-302a-3p
hsa-miR-302b-3p
hsa-miR-302c-3p
hsa-miR-302d-3p
hsa-miR-302e
hsa-miR-372-3p
hsa-miR-373-3p
hsa-miR-4731-5p
hsa-miR-512-3p
hsa-miR-519d-3p
hsa-miR-520a-3p
hsa-miR-520b
hsa-miR-520c-3p
hsa-miR-520d-3p
hsa-miR-520e
hsa-miR-526b-3p
hsa-miR-5589-5p
hsa-miR-619-5p
hsa-miR-6506-5p
hsa-miR-93-5p
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
 atcccaGCACTTT
atcccaGCACTTT
atcccaGCACTTT
atcccaGCACTTT
atcccaGCACTTT
atcccAGCACTTt
atcccAGCACTTt
atcccAGCACTTt
atcccAGCACTTt
atcccAGCACTTt
atcccAGCACTTt
atcccAGCACTTt
atCCCAGCActtt
atccCAGCACTtt
atcccaGCACTTT
atcccAGCACTTt
atcccAGCACTTt
atcccAGCACTTt
atcccAGCACTTt
atcccAGCACTTt
atcccaGCACTTT
atCCCAGCActtt
ATCCCAGcacttt
ATCCCAGcacttt
atcccaGCACTTT
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
 0.133
0.152
0.133
0.143
0.143
0.143
0.143
0.143
0.143
0.152
0.124
0.124
-0.012
0.077
0.133
0.143
0.124
0.124
0.143
0.143
0.133
-0.002
-0.086
0.034
0.143
A hsa-miR-3147
hsa-miR-4425
hsa-miR-450b-3p
hsa-miR-5089-5p
hsa-miR-6513-5p
hsa-miR-6728-5p
hsa-miR-769-3p
2
2
2
2
2
2
2
 atCCCAACActtt
aTCCCAACActtt
ATCCCAAcacttt
ATCCCAAcacttt
ATCCCAAcacttt
ATCCCAAcacttt
ATCCCAAcacttt
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 -0.007
-0.069
0.026
0.001
0.065
0.046
0.036
43619184 rs9357417 C C hsa-miR-1295a
hsa-miR-5704
1
1
 acCGGCCTAAgcc
accGGCCTAAgcc
 Disrupted
Disrupted
N
N
 -0.178
-0.051
T hsa-miR-4720-3p
1
 accggCTTAAGCc
 Created
N
 0.094
43619325 rs181984888 G G hsa-miR-3944-5p
1
 tgtgccGCTGCAC
 Disrupted
N
 -0.02
A hsa-miR-143-5p
hsa-miR-5693
hsa-miR-6499-3p
hsa-miR-891a-3p
1
1
1
1
 tgtgccACTGCAC
tgtGCCACTGcac
tgtgcCACTGCAc
tGTGCCACtgcac
 Created
Created
Created
Created
N
N
N
N
 0.028
-0.058
0.024
-0.083

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