SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_006226 |
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Gene Symbol: | PLCL1 |
Description: | Homo sapiens phospholipase C-like 1 (PLCL1), mRNA. |
Gene Location: | chr2(+):198669425-199014608 |
Browse Associations |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.198147018C>G | 0_111 | Lung cancer | |||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3529-3p |
tttctcaTTGTTGTTttct |
0 | AACAACAA | m8a | Created | -0.124 | -0.295 |
-1.02 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.198147460T>C | COSN8277027 | PCSI_0083_Pa_P_526 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3161 |
aagccaaatTTATCAaagc |
0 | CUGAUAAG | m6b | Disrupted | -0.278000 | -0.249000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.198147639T>C | COSN6163219 | RK111_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1200 |
atcaatttTCAGGAagttt |
0 | CUCCUGAG | m6b | Created | no TS | -0.105000 |
-0.020000 |
|
hsa-miR-3140-5p |
atcaattTTCAGGaagttt |
0 | ACCUGAAU | m6b | Created | no TS | -0.101000 |
-0.400000 |
|
hsa-miR-378a-5p |
atcaatttTCAGGAagttt |
0 | CUCCUGAC | m6b | Created | no TS | -0.094000 |
-0.270000 |
|
hsa-miR-5009-3p |
atcaattTTTAGGAagttt |
0 | UCCUAAAU | m7a | Disrupted | -0.122000 | -0.070000 |
0.510000 |
|
hsa-miR-548c-3p |
atcaATTTTTaggaagttt |
2 |
CAAAAAUC | m6b | Disrupted | 0.549000 | 0.418000 |
0.010000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.198147671A>G | COSN9302744 | AOCS-116-1-3 | [ovary][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4717-3p |
actaaaCATGTGatttcac |
0 | ACACAUGG | m6b | Created | no TS | -0.071000 |
-0.570000 |
|
hsa-miR-5007-3p |
actaaaCATATGATttcac |
9 |
AUCAUAUG | m8a | Disrupted | -0.096000 | 0.047000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.198147772C>A | COSN6680100 | CHC322T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-130a-5p |
ttgATGTGAAaataatatt |
0 | UUCACAUU | m7a | (m6a->m7a) | no TS | -0.044000 |
-0.710000 |
|
hsa-miR-5096 |
ttgatGTGAAAataatatt |
2 |
GUUUCACC | m6b | Created | -0.007000 | -0.019000 | No effect | |
hsa-miR-5701 |
ttgatgtGACAATAAtatt |
4 |
UUAUUGUC | m8a | Disrupted | -0.136000 | no TS |
3.150000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.198147804A>G | COSN1817581 | RK133_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1260a |
gagatttGTGGGAaggtct |
0 | AUCCCACC | m6b | Created | -0.227000 | -0.308000 | No effect | |
hsa-miR-1260b |
gagatttGTGGGAaggtct |
0 | AUCCCACC | m6b | Created | -0.237000 | -0.314000 |
-0.030000 |
|
hsa-miR-1283 |
gagaTTTGTAGgaaggtct |
1 |
UCUACAAA | m7b | Disrupted | -0.116000 | -0.101000 | No effect | |
hsa-miR-155-3p |
gagattTGTAGGAaggtct |
4 |
CUCCUACA | m7b | Disrupted | -0.219000 | no TS |
0.150000 |
|
hsa-miR-188-3p |
gagattTGTGGGAaggtct |
4 |
CUCCCACA | m7b | Created | -0.071000 | -0.287000 |
-0.040000 |
|
hsa-miR-3156-3p |
gagatttGTGGGAaggtct |
4 |
CUCCCACU | m6b | Created | -0.074000 | -0.170000 |
-0.020000 |
|
hsa-miR-3667-3p |
gagatttgtAGGAAGGTct |
5 |
ACCUUCCU | m8a | (m8a->m7b) | -0.116000 | no TS | No effect | |
hsa-miR-3685 |
gagatttGTAGGAAggtct |
4 |
UUUCCUAC | m7b | Disrupted | -0.082000 | no TS |
0.010000 |
|
hsa-miR-4719 |
gagATTTGTGggaaggtct |
5 |
UCACAAAU | m7b | (m6b->m7b) | 0.018000 | 0.064000 |
-0.020000 |
|
hsa-miR-1260a |
gagatttGTGGGAaggtct |
0 | AUCCCACC | m6b | Created | -0.227 | -0.308 | No effect | |
hsa-miR-1260b |
gagatttGTGGGAaggtct |
0 | AUCCCACC | m6b | Created | -0.237 | -0.314 |
-0.03 |
|
hsa-miR-1283 |
gagaTTTGTAGgaaggtct |
5 |
UCUACAAA | m7b | Disrupted | -0.116 | -0.101 | No effect | |
hsa-miR-155-3p |
gagattTGTAGGAaggtct |
4 |
CUCCUACA | m7b | Disrupted | -0.219 | no TS |
0.15 |
|
hsa-miR-188-3p |
gagattTGTGGGAaggtct |
0 | CUCCCACA | m7b | Created | -0.071 | -0.287 |
-0.04 |
|
hsa-miR-3156-3p |
gagatttGTGGGAaggtct |
0 | CUCCCACU | m6b | Created | -0.074 | -0.17 |
-0.02 |
|
hsa-miR-3667-3p |
gagatttgtAGGAAGGTct |
0 | ACCUUCCU | m8a | (m8a->m7b) | -0.116 | no TS | No effect | |
hsa-miR-3685 |
gagatttGTAGGAAggtct |
4 |
UUUCCUAC | m7b | Disrupted | -0.082 | no TS |
0.01 |
|
hsa-miR-4719 |
gagATTTGTGggaaggtct |
0 | UCACAAAU | m7b | (m6b->m7b) | 0.018 | 0.064 |
-0.02 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.198147808A>C | COSN9871087 | C0059T | [kidney][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3667-3p |
tttgtAGGAAGGTctcatt |
5 |
ACCUUCCU | m8a | Disrupted | -0.116000 | no TS |
0.010000 |
|
hsa-miR-3685 |
tttGTAGGAAggtctcatt |
4 |
UUUCCUAC | m7b | (m7b->m6b) | -0.082000 | no TS |
0.010000 |
|
hsa-miR-769-5p |
tttgtaggaAGGTCTCAtt |
3 |
UGAGACCU | m8a | (m8a->m7b) | -0.246000 | -0.103000 |
-0.100000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.198148283G>T | 9_105036 | CRC-9-Tumor | Colorectal adenocarcinoma | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1251 |
aaacCTAGAGaagataatt |
13 |
ACUCUAGC | m6b | Disrupted | -0.042 | no TS |
6.14 |
|
hsa-miR-4684-5p |
aaaccTAGAGAagataatt |
13 |
CUCUCUAC | m6b | Disrupted | -0.086 | -0.12 | No effect | |
hsa-miR-517-5p |
aaacCTAGAGaagataatt |
13 |
CCUCUAGA | m6b | Disrupted | -0.029 | no TS | No effect | |
hsa-miR-942 |
aaacctAGAGAAGAtaatt |
12 |
UCUUCUCU | m8a | Disrupted | -0.024 | no TS | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.198148516A>C | COSN7156590 | 8031121 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.198148579A>G | COSN1817582 | RK075_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr2:g.198148828G>C | COSN1817583 | RK046_C02 | [liver][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-3909 |
ggaAGAGGACAtaaaggat |
0 | UGUCCUCU | m8a | Created | no TS | -0.207000 | No effect |
hsa-miR-4279 |
ggaaGAGGAGAtaaaggat |
1 |
CUCUCCUC | m7b | Disrupted | -0.096000 | no TS | No effect |
hsa-miR-3909 |
ggaAGAGGACAtaaaggat |
0 | UGUCCUCU | m8a | Created | no TS | -0.207 | No effect |
hsa-miR-4279 |
ggaaGAGGAGAtaaaggat |
1 |
CUCUCCUC | m7b | Disrupted | -0.096 | no TS | No effect |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
198148113 | rs138546507 | T | T |
hsa-miR-548c-3p |
7 |
aggtaATTTTTAc |
Disrupted |
N |
0.218 |
A |
hsa-miR-4282 |
5 |
aggtAAATTTTAc |
Created |
N |
0.293 |
|||
198149792 | rs181017087 | G | G |
hsa-miR-1283 hsa-miR-187-5p hsa-miR-221-3p hsa-miR-222-3p hsa-miR-548v |
1 1 1 1 1 |
TTTGTAGcagggt tTTGTAGCAgggt ttTGTAGCAgggt ttTGTAGCAgggt ttTGTAGCAgggt |
Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N |
-0.101 -0.383 -0.152 -0.159 -0.161 |
A |
hsa-miR-10a-5p hsa-miR-10b-5p hsa-miR-520d-5p hsa-miR-524-5p |
1 1 1 1 |
tttgtaACAGGGT tttgtaACAGGGT TTTGTAAcagggt TTTGTAAcagggt |
Created Created Created Created |
N N N N |
-0.321 -0.33 -0.013 -0.013 |