SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_181839
Gene Symbol: PKIA
Description: Homo sapiens protein kinase (cAMP-dependent, catalytic) inhibitor alpha (PKIA), transcript variant 1, mRNA.
Gene Location: chr8(+):79428335-79517502
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr8:g.78602500C>A COSN8519484 4537_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3153 cagtCTTTCCCCttgctca
 6
 GGGGAAAG m8a Disrupted -0.137000 -0.042000 0.010000
hsa-miR-4761-5p cagtctttCACCTTGctca
 0 ACAAGGUG m7b Created no TS -0.159000 -0.820000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.78602689C>A COSN9681543 AOCS-155-3-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1270 aactTCTCCAacataatat
 12
 CUGGAGAU m6b Created -0.205000 -0.278000 No effect
hsa-miR-299-3p aacttctCCCACATAatat
 1
 UAUGUGGG m8a Disrupted -0.295000 no TS 0.080000
hsa-miR-30c-1-3p aactTCTCCCAcataatat
 0 CUGGGAGA m7b Disrupted -0.269000 -0.105000 No effect
hsa-miR-30c-2-3p aactTCTCCCAcataatat
 0 CUGGGAGA m7b Disrupted -0.287000 -0.123000 No effect
hsa-miR-4296 aacttctCCCACATaatat
 0 AUGUGGGC m7a Disrupted NA NA No effect
hsa-miR-4491 aacttctcCCACATaatat
 7
 AAUGUGGA m6b Disrupted -0.141000 -0.041000 No effect
hsa-miR-4516 aaCTTCTCCCacataatat
 1
 GGGAGAAG m8a (m8a->m7a) -0.077000 -0.164000 No effect
hsa-miR-4531 aacTTCTCCAacataatat
 0 AUGGAGAA m7b (m6b->m7b) no TS -0.173000 No effect
hsa-miR-4657 aacttctcCCACATaatat
 7
 AAUGUGGA m6b Disrupted -0.139000 -0.032000 No effect
hsa-miR-4769-5p aacttcTCCCACataatat
 1
 GGUGGGAU m6b Disrupted -0.154000 no TS 0.010000
hsa-miR-4781-3p aacttctCCAACATaatat
 4
 AAUGUUGG m7b Created -0.247000 -0.463000 -0.070000
hsa-miR-620 aactTCTCCAacataatat
 12
 AUGGAGAU m6b Created -0.186000 -0.259000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr8:g.78602908A>G COSN7677886 ASHPC_0003_Pa_P_2 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr8:g.78602912C>A COSN9681544 AOCS-091-3-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3657 tgtGGACACAaatcacaaa
 0 UGUGUCCC m7a (m6a->m7a) no TS -0.085000 0.830000
hsa-miR-4669 tgtGGACACAaatcacaaa
 0 UGUGUCCG m7a (m6a->m7a) no TS -0.087000 0.010000
hsa-miR-5010-3p tgtggACACAAAtcacaaa
 11
 UUUUGUGU m7b Created 0.068000 0.108000 No effect
hsa-miR-509-3p tgtggacACCAATCAcaaa
 14
 UGAUUGGU m8a Disrupted -0.084000 no TS 0.380000
hsa-miR-592 tgtgGACACAAatcacaaa
 0 UUGUGUCA m7a Created no TS -0.049000 No effect
hsa-miR-599 tgtgGACACAAatcacaaa
 0 GUUGUGUC m7b Created no TS -0.041000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.78603280C>T COSN9681545 AOCS-155-3-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4417 aataacgAGCCCACttagc
 6
 GGUGGGCU m7b Disrupted -0.042000 no TS 0.860000
hsa-miR-4674 aataacGAGCCCActtagc
 5
 CUGGGCUC m7b Disrupted -0.036000 no TS 2.470000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.78603366C>T COSN8519485 2275_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3128 gtggttgTGCCAGAaactc
 2
 UCUGGCAA m7a Disrupted -0.032000 no TS -0.710000
hsa-miR-3660 gtggttgTGTCAGaaactc
 16
 ACUGACAG m6b Created -0.078000 -0.057000 -0.550000
hsa-miR-4256 gtggttgtGTCAGAaactc
 0 AUCUGACC m6b Created no TS 0.029000 -0.020000
hsa-miR-4526 gtggttgTGTCAGaaactc
 16
 GCUGACAG m6b Created -0.081000 -0.053000 No effect
hsa-miR-4720-5p gtggttgTGCCAGaaactc
 2
 CCUGGCAU m6b Disrupted -0.023000 no TS 0.090000
hsa-miR-4762-3p gtggttgtgTCAGAAactc
 0 CUUCUGAU m6b Created no TS 0.097000 -0.020000
hsa-miR-4799-3p gtggttgTGCCAGaaactc
 2
 ACUGGCAU m6b Disrupted -0.030000 no TS 5.810000
hsa-miR-5588-5p gtggttgTGCCAGaaactc
 2
 ACUGGCAU m6b Disrupted -0.027000 no TS 0.020000
hsa-miR-642a-3p gtggtTGTGTCagaaactc
 0 AGACACAU m6b Created no TS 0.045000 No effect
hsa-miR-642b-3p gtggtTGTGTCagaaactc
 0 AGACACAU m6b Created no TS 0.045000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.78603464A>T COSN8326973 SS6003317 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-129-1-3p aatAAGGGCTTggttgcat
 18
 AAGCCCUU m8a Created -0.265000 -0.336000 0.700000
hsa-miR-129-2-3p aatAAGGGCTTggttgcat
 18
 AAGCCCUU m8a Created -0.265000 -0.336000 0.490000
hsa-miR-938 aaTAAGGGCAtggttgcat
 3
 UGCCCUUA m8a (m8a->m7a) -0.073000 -0.053000 0.900000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.78603760A>T COSN9681546 AOCS-104-1-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4282 tgtgAATTTTAacttctct
 0 UAAAAUUU m7a Created 0.620000 0.834000 No effect
hsa-miR-4670-3p tgtgaatttTAACTTCtct
 0 UGAAGUUA m7b (m6c->m7b) no TS 0.001000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.78604073A>G COSN8103313 8066464 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4659a-5p tgcttattCATGGCAtctt
 0 CUGCCAUG m7b Disrupted -0.167000 no TS 0.470000
hsa-miR-4659b-5p tgcttattCATGGCAtctt
 0 UUGCCAUG m7b Disrupted -0.167000 no TS 0.450000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.78604367T>G COSN14496065 8069334 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3605-3p gtgatgaACGGAGGatttg
 0 CCUCCGUG m7a Created NA NA 0.110000
hsa-miR-4277 gtgatGAACTGaggatttg
 1
 GCAGUUCU m6b Disrupted -0.015000 no TS No effect
hsa-miR-5000-5p gtgaTGAACTGaggatttg
 0 CAGUUCAG m7a Disrupted NA NA No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.78605111C>T COSN4942055 PD4103a [breast][NS][carcinoma][ductal_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-376a-3p ggaaaggaTCTATGATtta
 4
 AUCAUAGA m8a Disrupted -0.213000 no TS -0.320000
hsa-miR-376b ggaaaggaTCTATGATtta
 4
 AUCAUAGA m8a Disrupted -0.213000 no TS -0.580000
hsa-miR-500a-5p ggaAAGGATTtatgattta
 0 UAAUCCUU m7b (m6b->m7b) no TS -0.195000 -0.880000
hsa-miR-501-5p ggAAAGGATTtatgattta
 8
 AAUCCUUU m8a (m7a->m8a) -0.120000 -0.147000 -0.020000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.78605156A>G COSN9681547 AOCS-112-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-106a-3p tctttaATTGCAagagtgg
 4
 CUGCAAUG m6b Created -0.139000 -0.228000 No effect
hsa-miR-2054 tctttaATTACAagagtgg
 2
 CUGUAAUA m6b Disrupted -0.049000 no TS 0.320000
hsa-miR-643 tctttaatTACAAGagtgg
 2
 ACUUGUAU m6b Disrupted -0.093000 no TS 0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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