SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_170724
Gene Symbol:	PKHD1
Description:	Homo sapiens polycystic kidney and hepatic disease 1 (autosomal recessive) (PKHD1), transcript variant 1, mRNA.
Gene Location:	chr6(-):51585646-51952423
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.51721132T>A			COSN2166067		RK089_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-323b-3p	ttccatTATTGGaacagtg	2	CCCAAUAC	m6b	Disrupted	-0.057000	no TS	No effect
hsa-miR-337-3p	ttccatTATAGGAacagtg	0	CUCCUAUA	m7b	Created	no TS	-0.229000	-0.330000
hsa-miR-323b-3p	ttccatTATTGGaacagtg	0	CCCAAUAC	m6b	Disrupted	-0.057	no TS	No effect
hsa-miR-337-3p	ttccatTATAGGAacagtg	0	CUCCUAUA	m7b	Created	no TS	-0.229	-0.33

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.51721467G>T			COSN1334335		HX15T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4684-5p	tatgGTAGAGAagccttat	2	CUCUCUAC	m7b	Disrupted	-0.203000	no TS	No effect
hsa-miR-942	tatggtAGAGAAGccttat	1	UCUUCUCU	m7b	Disrupted	-0.224000	-0.128000	No effect
hsa-miR-4684-5p	tatgGTAGAGAagccttat	0	CUCUCUAC	m7b	Disrupted	-0.203	no TS	No effect
hsa-miR-942	tatggtAGAGAAGccttat	0	UCUUCUCU	m7b	Disrupted	-0.224	-0.128	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.51721974G>A			COSN167788		GC8_T		[stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1184	gaggagcCTGCAGGaagct	0	CCUGCAGC	m7a	Disrupted	NA	NA	No effect
hsa-miR-1205	gaggagCCTGCAGgaagct	0	UCUGCAGG	m7b	Disrupted	0.000000	no TS	No effect
hsa-miR-3074-5p	gaggagcctGCAGGAAgct	10	GUUCCUGC	m7b	(m7b->m6b)	0.000000	-0.155000	-0.020000
hsa-miR-3155a	gagGAGCCTGcaggaagct	2	CCAGGCUC	m7b	(m7b->m6c)	0.000000	no TS	No effect
hsa-miR-3155b	gagGAGCCTGcaggaagct	2	CCAGGCUC	m7b	(m7b->m6c)	0.000000	no TS	No effect
hsa-miR-3158-5p	gaggagcCTGCAGGaagct	0	CCUGCAGA	m7a	Disrupted	NA	NA	No effect
hsa-miR-484	gagGAGCCTGcaggaagct	2	UCAGGCUC	m7b	(m7b->m6c)	0.000000	no TS	No effect
hsa-miR-486-5p	gaggagccTACAGGAagct	0	UCCUGUAC	m7a	Created	no TS	0.000000	No effect
hsa-miR-1184	gaggagcCTGCAGGaagct	0	CCUGCAGC	m7a	Disrupted	NA	NA	No effect
hsa-miR-1205	gaggagCCTGCAGgaagct	0	UCUGCAGG	m7b	Disrupted	0	no TS	No effect
hsa-miR-3074-5p	gaggagcctGCAGGAAgct	0	GUUCCUGC	m7b	(m7b->m6b)	0	-0.155	-0.02
hsa-miR-3155a	gagGAGCCTGcaggaagct	0	CCAGGCUC	m7b	(m7b->m6c)	0	no TS	No effect
hsa-miR-3155b	gagGAGCCTGcaggaagct	0	CCAGGCUC	m7b	(m7b->m6c)	0	no TS	No effect
hsa-miR-3158-5p	gaggagcCTGCAGGaagct	0	CCUGCAGA	m7a	Disrupted	NA	NA	No effect
hsa-miR-484	gagGAGCCTGcaggaagct	0	UCAGGCUC	m7b	(m7b->m6c)	0	no TS	No effect
hsa-miR-486-5p	gaggagccTACAGGAagct	0	UCCUGUAC	m7a	Created	no TS	0	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
51720900	rs112467022	G	G	hsa-miR-365a-3p hsa-miR-365b-3p	2 2	tattGGGCATTta tattGGGCATTta	Disrupted Disrupted	N N	-0.326 -0.326
			A	hsa-miR-323b-3p	5	TATTGGAcattta	Created	N	-0.11
51721973	rs9349593	T	C	hsa-miR-1205 hsa-miR-3074-5p hsa-miR-6511b-5p hsa-miR-6811-5p	0	agCCTGCAGgaag agcctGCAGGAAg aGCCTGCAggaag aGCCTGCAggaag	Created Created Created Created	N N N N	No Change No Change No Change No Change
			T	hsa-miR-155-3p hsa-miR-3685 hsa-miR-4438 hsa-miR-5095 hsa-miR-7151-3p	0	agccTGTAGGAAg agcctGTAGGAAg AGCCTGTAggaag aGCCTGTAggaag aGCCTGTAggaag	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	No Change No Change No Change No Change No Change
51721974	rs45451196	G	G	hsa-miR-1205 hsa-miR-3074-5p hsa-miR-3155a hsa-miR-3155b hsa-miR-484 hsa-miR-6511b-5p hsa-miR-6811-5p	0	gagCCTGCAGgaa gagcctGCAGGAA GAGCCTGcaggaa GAGCCTGcaggaa GAGCCTGcaggaa gaGCCTGCAggaa gaGCCTGCAggaa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	No Change No Change No Change No Change No Change No Change No Change
			A	hsa-miR-486-5p hsa-miR-6806-5p hsa-miR-7152-5p	8 0 1	gagccTACAGGAa gaGCCTACAggaa gagcctACAGGAA	Created Created Created	N N N	No Change No Change No Change

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