SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
  Home Search Help Download  

PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_138694
Gene Symbol: PKHD1
Description: Homo sapiens polycystic kidney and hepatic disease 1 (autosomal recessive) (PKHD1), transcript variant 1, mRNA.
Gene Location: chr6(-):51480144-51952423
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr6:g.51615568C>A COSN4955913 SS6003323 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr6:g.51615645A>T COSN15499996 AOCS-135-8-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr6:g.51616064A>T COSN5088953 HX21T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-302b-5p atttgtcaaTTAAAGaaca
 2
 ACUUUAAC m6b Created 0.050000 0.077000 No effect
hsa-miR-302d-5p atttgtcaaTTAAAGaaca
 2
 ACUUUAAC m6b Created 0.041000 0.071000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.51616189A>G COSN7791581 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-129-5p gttctcaccGCAAAAAatg
 6
 CUUUUUGC m7b (m6b->m7b) 0.192000 0.147000 -0.250000
hsa-miR-2113 gttctcacCACAAAaaatg
 3
 AUUUGUGC m6b Disrupted 0.007000 no TS No effect
hsa-miR-450a-5p gttctcacCGCAAAAaatg
 0 UUUUGCGA m7a Created no TS -0.135000 0.060000
hsa-miR-4746-3p gttctCACCGCaaaaaatg
 0 AGCGGUGC m6b Created no TS -0.188000 No effect
hsa-miR-5010-3p gttctcacCACAAAAaatg
 3
 UUUUGUGU m7a Disrupted 0.014000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.51616783A>C COSN9796829 AOCS-124-1-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1302 ctatgTGTCCCAAgaccag
 0 UUGGGACA m8a Created no TS -0.067000 -4.570000
hsa-miR-3122 ctatgtGTCCCAAgaccag
 0 GUUGGGAC m7b Created no TS -0.059000 -4.400000
hsa-miR-3913-5p ctatgtGTCCCAAgaccag
 0 UUUGGGAC m7b Created no TS -0.021000 -0.220000
hsa-miR-4298 ctatgTGTCCCAagaccag
 0 CUGGGACA m7b Created no TS -0.120000 -4.710000
hsa-miR-4504 ctatgTGTCACAagaccag
 1
 UGUGACAA m7a Disrupted -0.012000 no TS 10.710000
hsa-miR-542-3p ctatgTGTCACAagaccag
 1
 UGUGACAG m7a Disrupted -0.008000 no TS 4.190000
hsa-miR-635 ctatgtgtCCCAAGaccag
 0 ACUUGGGC m6b Created no TS 0.014000 -2.320000
hsa-miR-758 ctatgtGTCACAAgaccag
 1
 UUUGUGAC m7b Disrupted 0.122000 0.104000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.51616801A>C COSN15293573 0065_CRUK_PC_0065_T1_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p tatcttcTTCTTTatcctc
 5
 CAAAGAAU m6b Created 0.647000 0.800000 -0.010000
hsa-miR-3185 tatCTTCTTCTttatcctc
 1
 AGAAGAAG m8a Created 0.069000 0.060000 0.080000
hsa-miR-3653 tatCTTCTTAtttatcctc
 4
 CUAAGAAG m7b (m7b->m6c) 0.011000 no TS 2.070000
hsa-miR-5692a tatcttcTTATTTatcctc
 0 CAAAUAAU m6b Disrupted 0.396000 0.186000 0.070000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.51616867A>G COSN9312609 8068585 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-618 ttcacaaAGAGTTagctgc
 1
 AAACUCUA m6b Disrupted 0.085000 no TS No effect
hsa-miR-652-5p ttcacaaAGGGTTagctgc
 0 CAACCCUA m6b Created no TS 0.008000 -9.630000


Mutation Mutation ID Sample Name Cancer Type
chr6:g.51617227T>C 11_19698 2542 Breast cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr6:g.51617312A>T COSN2166036 RK089_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-577 cagttaTTTATCTtttttt
 2
 UAGAUAAA m7b Disrupted 0.082000 0.075000 0.050000
hsa-miR-577 cagttaTTTATCTtttttt
 0 UAGAUAAA m7b Disrupted 0.082 0.075 0.05

Mutation Mutation ID Sample Name Cancer Type
chr6:g.51617536A>G COSN7791582 PCSI_0098_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1269a gagatttCAGTCCAGgcta
 0 CUGGACUG m8a Created no TS -0.020000 No effect
hsa-miR-1269b gagatttCAGTCCAGgcta
 0 CUGGACUG m8a Created no TS -0.029000 No effect
hsa-miR-3690 gagatttcaGTCCAGGcta
 0 ACCUGGAC m7b (m6b->m7b) -0.009000 -0.043000 -0.280000
hsa-miR-378a-3p gagatttcAGTCCAGgcta
 0 ACUGGACU m7b Created no TS 0.018000 -0.250000
hsa-miR-378b gagatttcAGTCCAGgcta
 0 ACUGGACU m7b Created no TS 0.036000 -0.160000
hsa-miR-378c gagatttcAGTCCAGgcta
 0 ACUGGACU m7b Created no TS 0.018000 -0.390000
hsa-miR-378d gagatttcAGTCCAGgcta
 0 ACUGGACU m7b Created no TS 0.018000 -0.940000
hsa-miR-378e gagatttcAGTCCAGgcta
 0 ACUGGACU m7b Created no TS 0.018000 -0.700000
hsa-miR-378f gagatttcAGTCCAGgcta
 0 ACUGGACU m7b Created no TS 0.018000 -0.120000
hsa-miR-378h gagatttcAGTCCAGgcta
 0 ACUGGACU m7b Created no TS 0.018000 -0.140000
hsa-miR-378i gagatttcAGTCCAGgcta
 0 ACUGGACU m7b Created no TS 0.018000 -0.050000
hsa-miR-422a gagatttcAGTCCAGgcta
 0 ACUGGACU m7b Created no TS 0.018000 -0.430000
hsa-miR-4515 gagatttCAGTCCaggcta
 0 AGGACUGG m6b Created no TS -0.003000 -3.260000
hsa-miR-4740-5p gagattTCAGTCCaggcta
 0 AGGACUGA m7b Created no TS -0.088000 -0.150000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.51618346T>C COSN6323784 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2278 tgaccaCTGCTCTattttt
 2
 GAGAGCAG m7b Created -0.137000 -0.384000 -0.460000
hsa-miR-4468 tgaccaCTGCTCTattttt
 0 AGAGCAGA m7a Created NA NA -0.180000
hsa-miR-4519 tgacCACTGCTctattttt
 0 CAGCAGUG m7b Created no TS -0.116000 -0.040000
hsa-miR-4773 tgaccaCTGTTCTattttt
 0 CAGAACAG m7b Disrupted -0.193000 no TS 0.560000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.51618644A>G COSN7791583 PCSI_0078_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3140-3p ttacagAAAAGCatttctt
 2
 AGCUUUUG m6b Disrupted -0.015000 0.019000 1.030000
hsa-miR-532-5p ttacagaAAGGCATttctt
 0 CAUGCCUU m7b Created no TS -0.212000 -3.290000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.51618855G>A COSN9908790 C0091T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3135a tcaatgCTAGGCAaataat
 2
 UGCCUAGG m7a Disrupted -0.221000 no TS 0.610000
hsa-miR-3152-5p tcaatgctAGGCAAataat
 4
 AUUGCCUC m6b Disrupted -0.134000 no TS No effect
hsa-miR-4774-3p tcaatgcTAGGCAAataat
 1
 AUUGCCUA m7b Disrupted -0.312000 no TS 0.040000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.51618874T>C COSN7886298 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-433 cagctATCATGATcctagt
 0 AUCAUGAU m8a Disrupted -0.275000 -0.149000 3.100000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
51616827 rs184699503 C C hsa-miR-3154
hsa-miR-3185
5
1
 tttaCCCTTCTtc
tttaccCTTCTTC
 Disrupted
Disrupted
N
N
 -0.066
0.069
A hsa-miR-4790-3p
5
 tttACCATTCttc
 Created
N
 -0.042
51616873 rs2784200 G A hsa-miR-3179
hsa-miR-3611
hsa-miR-6844
hsa-miR-6864-5p
hsa-miR-7515
hsa-miR-758-3p
0 CCCTTCAcaaaga
ccCTTCACAAaga
cccttcACAAAGA
CCCTTCAcaaaga
CCCTTCAcaaaga
ccctTCACAAAga
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 0.002
0.062
0.145
0.014
0.012
0.104
G hsa-miR-450a-5p
0 ccctTCGCAAAga
 Disrupted
N
 -0.034
51617209 rs150090821 A A hsa-miR-33a-3p
hsa-miR-4307
4
4
 aaaaAAACATTtc
aaaAAAACATttc
 Disrupted
Disrupted
N
N
 0.119
0.103
G hsa-miR-3140-3p
5
 aaAAAAGCAtttc
 Created
N
 0.101

Genome Browser