SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_015032
Gene Symbol:	PDS5B
Description:	Homo sapiens PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) (PDS5B), mRNA.
Gene Location:	chr13(+):33160563-33352158
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32775157A>G			COSN6410198		HCC99T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3189-5p	caaaATGGGGCtgctgaag	0	UGCCCCAU	m7b	Created	-0.218000	-0.520000	No effect
hsa-miR-424-5p	caaaatgggGCTGCTGaag	0	CAGCAGCA	m7a	(m6b->m7a)	NA	NA	No effect
hsa-miR-4274	caaaatggGACTGCTGaag	9	CAGCAGUC	m8a	Disrupted	-0.173000	no TS	5.270000
hsa-miR-4323	caaaaTGGGGCTGctgaag	0	CAGCCCCA	m8a	Created	no TS	-0.277000	-8.790000
hsa-miR-4519	caaaatgggACTGCTGaag	0	CAGCAGUG	m7a	(m7a->m6b)	NA	NA	4.590000
hsa-miR-497-5p	caaaatgggGCTGCTGaag	0	CAGCAGCA	m7a	(m6b->m7a)	NA	NA	No effect
hsa-miR-5588-3p	caaaaTGGGACTgctgaag	10	AAGUCCCA	m7b	Disrupted	-0.259000	no TS	0.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32775319C>T			COSN1157643		BN04T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32776038T>G			COSN8779516		AOCS-117-3-3		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-10a-5p	ccgtaACAGGGTAaagtta	0	UACCCUGU	m8a	Created	no TS	-0.272000	-6.650000
hsa-miR-10b-5p	ccgtaACAGGGTAaagtta	0	UACCCUGU	m8a	Created	no TS	-0.272000	-10.250000
hsa-miR-1208	ccgtAACAGTGtaaagtta	8	UCACUGUU	m7b	Disrupted	-0.079000	no TS	0.060000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32776122T>G			COSN4735405		tumor_4188900		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3163	tttgtATTTTATAgtgagt	16	UAUAAAAU	m8a	Disrupted	0.696000	0.457000	0.090000
hsa-miR-3671	tttgTATTTGATagtgagt	8	AUCAAAUA	m8a	Created	0.039000	0.110000	-1.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32776195C>T			COSN1157645		HX10T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32776333T>A			COSN5796953		EOPC-01_tumor		[prostate][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-139-5p	cagctACTGTAGttgtcac	7	UCUACAGU	m7b	Disrupted	-0.032000	no TS	1.080000
hsa-miR-199a-3p	cagCTACTGTagttgtcac	0	ACAGUAGU	m7a	(m7a->m6a)	no TS	-0.016000	No effect
hsa-miR-199b-3p	cagCTACTGTagttgtcac	0	ACAGUAGU	m7a	(m7a->m6a)	no TS	-0.016000	No effect
hsa-miR-222-5p	cagCTACTGAagttgtcac	15	CUCAGUAG	m7b	(m6b->m7b)	-0.077000	-0.078000	-0.190000
hsa-miR-936	cagCTACTGTagttgtcac	17	ACAGUAGA	m7a	(m7a->m6a)	-0.201000	-0.205000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32776883A>G			COSN6226579		RK077_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4511	tattcaactGTTCTTCatt	3	GAAGAACU	m7a	(m6b->m7a)	-0.064000	-0.064000	-0.340000
hsa-miR-4773	tattcaaCTGTTCTtcatt	2	CAGAACAG	m7b	Created	-0.145000	-0.226000	-1.340000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32777428G>A			COSN6226580		RK195_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3938	atcttAGGGAATTatctta	0	AAUUCCCU	m8a	Created	no TS	-0.209000	-0.770000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32777518A>C			COSN5723665		HX27T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3908	aaaacattaATTGCTaaca	1	GAGCAAUG	m6b	Disrupted	-0.205000	-0.123000	No effect
hsa-miR-3942-5p	aaaacattaATTGCTaaca	1	AAGCAAUA	m6b	Disrupted	-0.214000	-0.126000	No effect
hsa-miR-451b	aaaacattaCTTGCTAaca	16	UAGCAAGA	m7a	(m6b->m7a)	-0.365000	-0.479000	No effect
hsa-miR-4703-5p	aaaacattaATTGCTAaca	1	UAGCAAUA	m7a	(m7a->m6b)	-0.208000	-0.123000	No effect
hsa-miR-4766-3p	aaaacattaATTGCTAaca	1	AUAGCAAU	m7b	(m7b->m6c)	-0.507000	-0.326000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32777942C>A			COSN1606359		RK177_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1206	cataATGAACAattgctat	0	UGUUCAUG	m7a	Disrupted	-0.115000	no TS	7.760000
hsa-miR-335-3p	cataATGAAAAAttgctat	1	UUUUUCAU	m8a	Created	0.074000	-0.082000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.32777995G>T			COSN7398724		8062308		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
32775396	rs12427439	T	T	hsa-miR-132-3p hsa-miR-212-3p hsa-miR-95-5p	3 3 18	cGACTGTTtattg cGACTGTTtattg cgactgTTTATTG	Disrupted Disrupted Disrupted	N N N	-0.113 -0.15 0.025
			C	hsa-miR-4274 hsa-miR-6792-5p	3 18	cGACTGCTtattg cgaCTGCTTAttg	Created Created	N N	-0.187 -0.163
32775827	rs139116176	A	A	hsa-miR-222-5p hsa-miR-323a-3p	15 21	taatgTACTGAAt TAATGTActgaat	Disrupted Disrupted	N N	-0.077 0.009
			G	hsa-miR-3065-3p hsa-miR-383-3p hsa-miR-4291	16 16 15	taatGTGCTGAat taatGTGCTGAat taatgTGCTGAAt	Created Created Created	N N N	-0.144 -0.114 -0.095
32775896	rs189555398	A	A	hsa-miR-6504-3p	14	ttCTGTAATttga	Disrupted	N	-0.09
			T	hsa-miR-3671	13	ttctgtTATTTGA	Created	N	-0.034
32776116	rs144032898	G
			A	hsa-miR-3163	19	tgTTTTATAtttt	Created	N	0.121
32777174	rs148031257	T
			A	hsa-miR-3163 hsa-miR-448	14 15	TTTTATAtgcatg ttttATATGCAtg	Created Created	N N	0.147 -0.118
32777304	rs148057737	-	-	hsa-miR-3133 hsa-miR-4773	2 2	tgtctGTTCTTTt tgtCTGTTCTttt	Unknown Unknown	N N	-0.022 -0.094
			T
32777669	rs74045112	C	C	hsa-miR-187-5p hsa-miR-221-3p hsa-miR-222-3p hsa-miR-5089-3p hsa-miR-548v	11 11 11 11 9	cTGTAGCAaattt cTGTAGCAaattt cTGTAGCAaattt ctGTAGCAAattt CTGTAGCAaattt	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.145 -0.154 -0.144 -0.134 -0.371
			A	hsa-miR-139-5p	10	CTGTAGAaaattt	Created	N	-0.11

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